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Cell Adhesion Molecules

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Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

Also Known As:

Saccharide Mediated Cell Adhesion Molecules; Adhesion Molecules, Cell; Adhesion Molecules, Intercellular; Adhesion Molecules, Leukocyte; Molecules, Cell Adhesion; Molecules, Intercellular Adhesion; Molecules, Leukocyte Adhesion; Intercellular Adhesion Molecules; Leukocyte Adhesion Molecules; Saccharide-Mediated Cell Adhesion Molecules

Networked: 1915 relevant articles (16 outcomes, 196 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Südhof, Thomas C: 6 articles (08/2015 - 04/2008)
2.	Pyo, Suhkneung: 5 articles (01/2015 - 03/2003)
3.	Lee, Ho Sub: 5 articles (01/2013 - 08/2009)
4.	Lee, Yun Jung: 5 articles (01/2013 - 08/2009)
5.	Kang, Dae Gill: 5 articles (01/2013 - 08/2009)
6.	Chen, Xiaoyuan: 5 articles (01/2011 - 01/2004)
7.	Sato, Shinichi: 4 articles (09/2015 - 04/2003)
8.	Nachtigal, Petr: 4 articles (03/2015 - 01/2004)
9.	Wagner, William R: 4 articles (01/2014 - 09/2002)
10.	Schumacher, Udo: 4 articles (01/2014 - 01/2006)

Related Diseases

1.	Inflammation 02/02/2008 - "These data demonstrated the protective effects of Ad/vIL-10 on cerebrovascular dysfunction induced by inflammation, and proved that inhibition of expression of cell adhesion molecules should be one of ways of vIL-10 to protect vascular function during inflammation." 12/01/2002 - "The aim of this study was to investigate the expression of leukocyte adhesion molecules and the number of lymphoid follicles in gut mucosa of patients with spondyloarthropathy (SpA) in comparison with controls, in search for early immune alterations in the development of SpA-related gut inflammation. " 11/01/1996 - "Several recent studies have suggested that cell adhesion molecules on both neutrophils and vascular endothelial cells play an important role in the process of tissue inflammation. " 11/01/1992 - "Studies to date have demonstrated the key role of cell adhesion molecules in inflammation." 11/01/2015 - "The leukocyte integrin cell adhesion molecules α4β7 and αEβ7 mediate the homing and retention of lymphocytes to the gut, and sites of inflammation. "
2.	Stroke (Strokes) 09/01/2013 - "This indicates that this molecular MRI approach, which has been proven successful for in vivo detection of other types of cell adhesion molecules, is not invariably effective for MRI-based assessment of stroke-induced alterations in expression of cerebrovascular markers." 08/01/2009 - "This study aimed to evaluate whether leukocyte adhesion molecules can predict clinical outcome in patients after ischemic stroke. " 12/01/2006 - "The stroke trial - can we predict clinical outcome of patients with ischemic stroke by measuring soluble cell adhesion molecules (CAM)?" 07/01/2011 - "Role of cell adhesion molecules in acute ischemic stroke." 08/01/2009 - "The expressions of leukocyte adhesion molecules on admission are significantly increased in patients with acute ischemic stroke. "
3.	Atherosclerosis 01/01/2013 - "In conclusion, DYSGT improved the development of diabetic atherosclerosis via attenuation of the endothelial dysfunction, possibly by inhibiting ET-1, cell adhesion molecules, and lesion formation. " 03/01/2005 - "In this study, we investigated whether plasma levels of soluble cell adhesion molecules have potential value to predict atherosclerosis progression. " 05/01/2002 - "Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study." 07/01/2001 - "Studies have shown disparate results in relation to the role of plasma concentrations of cell adhesion molecules in atherosclerosis. " 05/01/2001 - "The main aims of the present study were therefore to investigate the relationship between subclinical atherosclerosis, cell-adhesion molecules and snpPLA2 in a group of subjects with hypercholesterolaemia and also in a healthy control group; and to investigate the relationship between conventional risk factors, cell-adhesion molecules and snpPLA2 in these groups. "
4.	Necrosis 12/01/2001 - "The effect of treatment on serum levels of soluble intercellular adhesion molecules and tumour necrosis factor-receptor 1 in psoriasis." 04/01/1996 - "Differential regulation of tissue-specific lymph node high endothelial venule cell adhesion molecules by tumour necrosis factor and transforming growth factor-beta 1." 05/01/2004 - "Binding of TNF-alpha to TNF-alpha receptor-1 (TNF-R1) activates death domain pathways, leading to necrosis and apoptosis in most tissues, and it also increases the expression of intercellular adhesion molecules (i.e., ICAM-1), which promote inflammation. " 07/01/2003 - "The overexpression of cell adhesion molecules on dermal vessels is important in the pathogenesis of psoriasis and is probably induced by upregulation of tumour necrosis factor (TNF)-alpha. " 01/01/2002 - "Expression of cell adhesion molecules, their ligands and tumour necrosis factor alpha in the liver of patients with metastatic gastrointestinal carcinomas."
5.	Infection 01/01/2013 - "These bacterial genes and cell adhesion molecules can potentially be used to control pneumococcal adherence occurring secondary to a viral infection." 07/01/2009 - "We investigate the effect of rhinovirus infection on the expression of cell adhesion molecules and bacterial adherence to primary human nasal epithelial cells. " 02/01/2008 - "It was previously reported that several kinds of intercellular adhesion molecules are closely related to chronic HBV infection. " 02/01/2006 - "Adhesion molecules play a crucial role in leucocyte recruitment following infection, and polymorphisms have been reported in the genes for key cell adhesion molecules. " 06/01/2000 - "Increased levels of soluble cell adhesion molecules (sCAM) have been reported in HIV-1 infection and may possibly contribute to altering the adhesion mechanisms of phagocytic cells. "

Related Drugs and Biologics

1.	Cytokines
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
4.	Interleukins
5.	Monoclonal Antibodies
6.	Fibronectins (Fibronectin)
7.	Peptides
8.	Heparin (Liquaemin)
9.	Leukotrienes
10.	Quercetin

Related Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal)
2.	Aftercare (After-Treatment)
3.	Organ Transplantation
4.	Estrogen Replacement Therapy
5.	Renal Dialysis (Hemodialysis)