HLA-DR4 Antigen (HLA DR4 Antigen)

06/01/1993 - "Rheumatoid arthritis, long known to be associated with HLA-DR4, provides a good model for review of this progress, demonstrating how methodologic advances have led to an improved understanding of the immunogenetic basis of this disease, with implications for both pathogenesis and potential therapeutic interventions."
01/01/2000 - "HLA-DR4 and rheumatoid arthritis: studies in mice and men."
01/01/1990 - "This study of 110 seropositive rheumatoid arthritis (RA) patients confirms the significant association of susceptibility to RA with HLA-DR4 specificity (P less than 0.001). "
05/01/1984 - "The apparent discrepancy between weak familial aggregation and the known strong HLA-DR4 association with rheumatoid arthritis was resolved by examining the mathematical relationship between the measures of association in the two different types of studies. "
06/01/1982 - "The results of a previous study led us to believe that the association of HLA-DR4 and rheumatoid arthritis could be of particular interest in our region. "

06/01/2005 - "Subtypes of HLA-DR4 are associated with susceptibility or protection against type 1 diabetes (T1DM). "
02/01/1997 - "[Study on the association of HLA-DR4 with IDDM susceptibility in a Chinese population]."
04/01/1996 - "The aim of this study was to determine the association between childhood insulin-dependent diabetes mellitus (IDDM) and HLA-DR4 subtypes and to test in a population-based investigation whether the DR4 association has an effect independent to that of DQ. "
08/01/2008 - "In contrast, the CT60AA genotype, but not the +49G>A variation, was associated with fulminant type 1 diabetes (P < 0.05), especially in patients carrying HLA-DR4 (P < 0.01). "
10/01/2003 - "In the case of IDDM this locus encodes alleles such as HLA-DR4, -DR3, and -DQ8 in humans and I-Ag7 in the non-obese diabetic (NOD) mouse. "

11/01/1994 - "This study suggested that HLA-DR4 may be related to the genetic susceptibility of PIH. "
12/01/1989 - "Immunogenetic studies indicate a marked genetic susceptibility to the disease, with the immune response-associated HLA-DR4 and DRw6 alleles being especially important. "
01/01/1989 - "A genetic predisposition would seem probable in view of epidemiological data (higher frequency in white caucasian races and in certain countries), the existence of rare familial forms (25 families reported), and the significant increase in incidence in unconnected cases with HLA DR4 antigen (6 studies). "
01/01/2017 - "A genetic predisposition to RA, such as HLA-DR4 positivity, indicates that dendritic cells (DC) are of crucial importance to pathogenesis by activating auto-reactive lymphocytes. "
02/01/2011 - "A total of 19 case-control studies including 1378 cases and 10,383 controls provided data on the association between HLA-DR4 antigen and genetic susceptibility to IDC. "

08/01/2010 - "Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice."
10/15/2003 - "To investigate the role of HLA-DR4 in predisposition to arthritis, we generated transgenic mice carrying DRB1*0401 and DRB1*0402 genes. "
07/01/1993 - "To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis. "
01/01/1991 - "Of 28 patients with chronic arthritis, 25 (89%) had the HLA-DR4 or -DR2 specificities compared with only 6 of 22 patients (27%) with arthritis of short duration (P = 0.00006). "
07/26/1990 - "Of the 80 patients with arthritis, 57 percent of those with chronic arthritis (12 to 48 months in duration) had the HLA-DR4 specificity; only 23 percent of those with arthritis of moderate duration (6 to 11 months) and only 9 percent of those with arthritis of short duration (1 to 5 months) had this specificity (P = 0.003). "

10/01/1990 - "Of 26 Ashkenazi Jewish patients with pemphigus vulgaris, 24 (92.3%) carried the major histocompatibility complex (MHC) class II alleles HLA-DR4, DQw3, of which all were of the subtype DR4, DQw8. "
08/01/1989 - "The autoimmune dermatologic disease pemphigus vulgaris (PV) is associated with the serotypes HLA-DR4 and HLA-DRw6. "
02/01/1981 - "The frequency of HLA-DR4 was significantly increased at P less than 0.02 in 37 unrelated pemphigus patients (62.2%), when compared with unrelated 73 healthy controls (30.1%). "
12/05/1995 - "Susceptibility to pemphigus vulgaris (PV), an autoimmune disease of the skin, is linked to a rare subtype of HLA-DR4 (DRB1*0402, 1 of 22 known DR4 subtypes). "
08/01/1992 - "Pemphigus vulgaris in siblings: HLA-DR4 and HLA-DQw3 and susceptibility to pemphigus."