HLA-DR4 Antigen (HLA DR4 Antigen)

Human immune-response, D-related antigen encoded by the D locus on chromosome 6 and found on lymphoid cells. It is strongly associated with rheumatoid arthritis and juvenile diabetes.

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Networked: 457 relevant articles (1 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	David, Chella S: 5 articles (01/2014 - 10/2003)
2.	Forsthuber, Thomas G: 3 articles (11/2013 - 04/2004)
3.	Cairns, Ewa: 3 articles (07/2012 - 03/2002)
4.	Taneja, Veena: 3 articles (08/2010 - 10/2003)
5.	Luthra, Harvinder: 3 articles (08/2010 - 10/2003)
6.	Behrens, Marshall: 3 articles (08/2010 - 10/2003)
7.	Szabó, Zoltán: 3 articles (01/2008 - 06/2004)
8.	Granados, Julio: 3 articles (10/2004 - 07/2002)
9.	Haeryfar, S M Mansour: 2 articles (09/2014 - 07/2012)
10.	Arulanandam, Bernard P: 2 articles (11/2013 - 12/2006)

Related Diseases

1.	Rheumatoid Arthritis 06/01/1993 - "Rheumatoid arthritis, long known to be associated with HLA-DR4, provides a good model for review of this progress, demonstrating how methodologic advances have led to an improved understanding of the immunogenetic basis of this disease, with implications for both pathogenesis and potential therapeutic interventions." 01/01/2013 - "Study of association between HLA-DR4 and DR53 and autoantibody detection in rheumatoid arthritis." 01/01/2000 - "HLA-DR4 and rheumatoid arthritis: studies in mice and men." 01/01/1990 - "This study of 110 seropositive rheumatoid arthritis (RA) patients confirms the significant association of susceptibility to RA with HLA-DR4 specificity (P less than 0.001). " 05/01/1984 - "The apparent discrepancy between weak familial aggregation and the known strong HLA-DR4 association with rheumatoid arthritis was resolved by examining the mathematical relationship between the measures of association in the two different types of studies. "
2.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 04/01/1996 - "The aim of this study was to determine the association between childhood insulin-dependent diabetes mellitus (IDDM) and HLA-DR4 subtypes and to test in a population-based investigation whether the DR4 association has an effect independent to that of DQ. " 10/01/2003 - "In the case of IDDM this locus encodes alleles such as HLA-DR4, -DR3, and -DQ8 in humans and I-Ag7 in the non-obese diabetic (NOD) mouse. " 01/01/2003 - "IDDM patients with HLA-DR4 had a statistically significantly higher graft survival rates than those without DR4 in Blacks, Whites, Hispanics, and Asians. " 01/01/2003 - "High values of relative risk of IDDM, noticed in persons with HLA-DR4 antigen, point to the degree of risk of IDDM, which is a disease with great socioeconomic importance in Vojvodina." 03/01/2000 - "HLA-DR4 is a primary disease association marker in type 1 diabetes mellitus (IDDM). "
3.	Genetic Predisposition to Disease (Genetic Predisposition) 11/01/1994 - "This study suggested that HLA-DR4 may be related to the genetic susceptibility of PIH. " 12/01/1989 - "Immunogenetic studies indicate a marked genetic susceptibility to the disease, with the immune response-associated HLA-DR4 and DRw6 alleles being especially important. " 01/01/1989 - "A genetic predisposition would seem probable in view of epidemiological data (higher frequency in white caucasian races and in certain countries), the existence of rare familial forms (25 families reported), and the significant increase in incidence in unconnected cases with HLA DR4 antigen (6 studies). " 02/01/2011 - "A total of 19 case-control studies including 1378 cases and 10,383 controls provided data on the association between HLA-DR4 antigen and genetic susceptibility to IDC. " 03/01/2002 - "In particular, HLA-DR4 contributes significantly to a genetic predisposition to SpA, which may have implications in our understanding of SpA pathogenesis."
4.	Arthritis (Polyarthritis) 08/01/2010 - "Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice." 08/15/2008 - "Delineating the role of the HLA-DR4 "shared epitope" in susceptibility versus resistance to develop arthritis." 01/01/2006 - "These experiments represent the first description of an analog peptide of CII recognized by T cells in the context of HLA-DR4 that can suppress autoimmune arthritis." 10/15/2003 - "To investigate the role of HLA-DR4 in predisposition to arthritis, we generated transgenic mice carrying DRB1*0401 and DRB1*0402 genes. " 07/01/1993 - "To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis. "
5.	Pemphigus (Pemphigus Vulgaris) 10/01/1990 - "Of 26 Ashkenazi Jewish patients with pemphigus vulgaris, 24 (92.3%) carried the major histocompatibility complex (MHC) class II alleles HLA-DR4, DQw3, of which all were of the subtype DR4, DQw8. " 02/01/1981 - "The frequency of HLA-DR4 was significantly increased at P less than 0.02 in 37 unrelated pemphigus patients (62.2%), when compared with unrelated 73 healthy controls (30.1%). " 12/05/1995 - "Susceptibility to pemphigus vulgaris (PV), an autoimmune disease of the skin, is linked to a rare subtype of HLA-DR4 (DRB1*0402, 1 of 22 known DR4 subtypes). " 08/01/1992 - "Pemphigus vulgaris in siblings: HLA-DR4 and HLA-DQw3 and susceptibility to pemphigus." 08/01/1989 - "The autoimmune dermatologic disease pemphigus vulgaris (PV) is associated with the serotypes HLA-DR4 and HLA-DRw6. "

Related Drugs and Biologics

1.	Antigens
2.	HLA-DR3 Antigen (HLA DR3 Antigen)
3.	Insulin (Novolin)
4.	Autoantibodies
5.	Antibodies
6.	Peptides
7.	HLA-DR53
8.	Genetic Markers (Genetic Marker)
9.	Epitopes
10.	Isoantigens (Alloantigen)

Related Therapies and Procedures

1.	Immunomodulation
2.	Immunotherapy
3.	Aftercare (After-Treatment)