HLA-DR3 Antigen (HLA DR3 Antigen)

10/01/1994 - "Previous studies have reached conflicting conclusions as to the role of these genes in IDDM; it is uncertain whether an increased frequency of the allele TAP2A and a concomitant decrease in TAP2B are independent disease associations or secondary to linkage disequilibrium (LD) between TAP2A and HLA-DR3. "
12/01/1990 - "Reports of various studies in this vein have ranged from stating that the association of DQA2"U" with IDDM exists even among subjects positive for HLA-DR3 and -DR4 to stating that the association of DQA2"U" with diabetes can be attributed to linkage disequilibrium between the DQA2"U" and some component(s) on the affected haplotypes. "
11/12/2023 - "Over 10% of individuals with type 1 diabetes (T1D) do not have high-risk HLA-DR3 or -DR4 haplotypes, and whether they carry distinct genetic risk is unknown. "
07/01/2023 - "HLA-DR3 mediated CD4 T cell response against GAD65 in type 1 diabetes patients."
01/01/2019 - "Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes."

10/01/1984 - "In 66 patients with rheumatoid arthritis (RA) a significant association between impaired sulphoxidation and toxicity (p less than 0.001) was found; HLA-DR3, although associated with toxicity (p less than 0.05), appeared to be an independent risk factor of most importance in the group with extensive sulphoxidation. "
12/01/1987 - "Five patients with active seronegative, rheumatoid arthritis, HLA-DR3 negative, received inadvertently 250 to 500 mg of aurothioglucose instead of their usual weekly dose, during standard remission-inducing chrysotherapy. "
10/01/2005 - "Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis."
09/01/1992 - "HLA-DR3, C4A*QO and toxicity from gold in rheumatoid arthritis."
10/01/1984 - "D-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3."

09/01/1987 - "Both HLA-DR3 (relative risk (RR) = 5.80) and -DR4 (RR = 2.87) showed positive associations with Type I diabetes mellitus in these patients whilst -DR2 (RR 0.16) and -DR5 (RR = 0.15) were negatively associated. "
05/01/1987 - "A high frequency of HLA-DR3 and/or DR4 was found in patients who developed diabetes mellitus. "
01/01/1982 - "The frequency of HLA-DR3 in patients with coeliac disease and diabetes mellitus (88 per cent), patients with coeliac disease only (88 per cent), and patients with insulin-dependent diabetes mellitus only (69 per cent), was significantly greater than in normal subjects (44 per cent). "
03/15/1983 - "The association of insulin-dependent (type I) diabetes mellitus with HLA-DR3 and DR4 and with several epidemiological, virological, immunological, and clinical data suggests a heterogenous pathogenesis. "
07/01/2001 - "We studied the value of pre-transplant oral glucose tolerance testing or maximum random plasma glucose, and HLA-DR3 and/or DR4 phenotype as predictors of post-transplantation diabetes mellitus in heart transplant recipients. "

10/01/2003 - "HLA-DR3 carriers of pregnant women and their fetuses have a susceptibility of HBV infection."
10/01/2003 - "Although the gene frequency of HLA-DR3 (30.0%) in neonates of intrauterine infection group was higher than that of intrauterine non-infection group (7.4%), but no statistical difference was found between the two group (P > 0.05). "
10/01/2003 - "(3) The frequency of HLA-DR3 of pregnant women in intrauterine infection group was significantly higher than that of intrauterine non-infection group (P < 0.05). "
05/01/2001 - "Recipient HLA-DR3, TNF-2 status and CMV infection were inter-related risk factors for chronic rejection of liver grafts."
05/01/2001 - "Recipient HLA-DR3 was a risk factor for chronic rejection (relative risk 3.41; 95% C.I. 1.66-7.03) which was elevated further by superimposed CMV infection (relative risk 5.01; 95% C.I. 2-12.55). "

09/01/2004 - "Susceptibility to sarcoidosis and coeliac disease has been linked to the class II haplotype HLA-DR3, DQ2, and an association between the two disorders has been suggested. "
01/01/1992 - "Restricted V alpha 2.3 gene usage by CD4+ T lymphocytes in bronchoalveolar lavage fluid from sarcoidosis patients correlates with HLA-DR3."
08/01/1995 - "Findings that were essentially in agreement in both populations were: (1) a positive association of sarcoidosis with HLA-A1, B8, and DR3 markers, and a negative association with HLA-B12 and DR4; (2) a prevalence of HLA-DR3 and DR4 among females and of DR5 among males; (3) a relationship of B13 and B35 with early onset and of A30, B8, DR3, and DR4 with late onset of disease; (4) an association of B27 with sarcoidosis restricted to the lungs; (5) a relationship of A1, B8, B27, and DR3 to roentgenologic stage I and of B12 and DR4 to stage III; and (6) an association of HLA-DR3 with a good outcome. "
09/01/1983 - "The strong association between the acute, prognostically beneficial manifestation of sarcoidosis and HLA-DR3 might partly be related to the presence of circulating immune complexes in acute sarcoidosis as well as to an immunogenetically determined handling of a postulated etiological antigen."