HLA-DR3 Antigen (HLA DR3 Antigen)

Human immune-response, D-related antigen encoded by the D locus on chromosome 6 and found on lymphoid cells. It is in linkage disequilibrium with HLA-A1 and HLA-B8. The HLA-DR3 antigen is strongly associated with celiac disease, Grave's disease, dermatitis herpetiformis, early-age onset myasthenia gravis, systemic lupus erythematosus, juvenile diabetes, and opportunistic infections in AIDS.

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Networked: 312 relevant articles (6 outcomes, 26 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	David, Chella S: 11 articles (11/2015 - 06/2004)
2.	Rajagopalan, Govindarajan: 7 articles (11/2015 - 02/2006)
3.	Tomer, Yaron: 6 articles (12/2009 - 07/2002)
4.	Tilahun, Ashenafi Y: 5 articles (11/2015 - 01/2011)
5.	Patel, Robin: 5 articles (01/2015 - 02/2006)
6.	Greenberg, David A: 4 articles (04/2006 - 07/2002)
7.	Ban, Yoshiyuki: 4 articles (04/2006 - 07/2002)
8.	David, C S: 4 articles (09/2004 - 03/2000)
9.	Mangalam, Ashutosh K: 3 articles (06/2012 - 04/2005)
10.	Mastaglia, F L: 3 articles (09/2011 - 09/2008)

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/01/1994 - "Previous studies have reached conflicting conclusions as to the role of these genes in IDDM; it is uncertain whether an increased frequency of the allele TAP2A and a concomitant decrease in TAP2B are independent disease associations or secondary to linkage disequilibrium (LD) between TAP2A and HLA-DR3. " 12/01/1990 - "Reports of various studies in this vein have ranged from stating that the association of DQA2"U" with IDDM exists even among subjects positive for HLA-DR3 and -DR4 to stating that the association of DQA2"U" with diabetes can be attributed to linkage disequilibrium between the DQA2"U" and some component(s) on the affected haplotypes. " 06/01/2002 - "The human gene is encoded on 6p21.3-p22 where recent linkage analysis has identified an association with insulin dependent diabetes mellitus (IDDM) susceptibility independent of HLA-DR3. " 04/01/2002 - "HLA-DR3 but not DR4 is associated with latent autoimmune diabetes in adults (LADA). " 07/01/1998 - "HLA-DR3 (p < or = 0.002), -DR4 (p < 0.003), and -DR53 (p < or = 0.001) were associated with IDDM. "
2.	Rheumatoid Arthritis 10/01/1984 - "In 66 patients with rheumatoid arthritis (RA) a significant association between impaired sulphoxidation and toxicity (p less than 0.001) was found; HLA-DR3, although associated with toxicity (p less than 0.05), appeared to be an independent risk factor of most importance in the group with extensive sulphoxidation. " 12/01/1987 - "Five patients with active seronegative, rheumatoid arthritis, HLA-DR3 negative, received inadvertently 250 to 500 mg of aurothioglucose instead of their usual weekly dose, during standard remission-inducing chrysotherapy. " 10/01/2005 - "Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis." 09/01/1992 - "HLA-DR3, C4A*QO and toxicity from gold in rheumatoid arthritis." 10/01/1984 - "D-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3."
3.	Infection 12/14/2012 - "A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice." 10/01/2003 - "HLA-DR3 carriers of pregnant women and their fetuses have a susceptibility of HBV infection." 10/01/2003 - "Although the gene frequency of HLA-DR3 (30.0%) in neonates of intrauterine infection group was higher than that of intrauterine non-infection group (7.4%), but no statistical difference was found between the two group (P > 0.05). " 10/01/2003 - "(3) The frequency of HLA-DR3 of pregnant women in intrauterine infection group was significantly higher than that of intrauterine non-infection group (P < 0.05). " 05/01/2001 - "Recipient HLA-DR3 was a risk factor for chronic rejection (relative risk 3.41; 95% C.I. 1.66-7.03) which was elevated further by superimposed CMV infection (relative risk 5.01; 95% C.I. 2-12.55). "
4.	Diabetes Mellitus 01/01/1998 - "Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule." 09/01/1987 - "Both HLA-DR3 (relative risk (RR) = 5.80) and -DR4 (RR = 2.87) showed positive associations with Type I diabetes mellitus in these patients whilst -DR2 (RR 0.16) and -DR5 (RR = 0.15) were negatively associated. " 05/01/1987 - "A high frequency of HLA-DR3 and/or DR4 was found in patients who developed diabetes mellitus. " 01/01/1982 - "The frequency of HLA-DR3 in patients with coeliac disease and diabetes mellitus (88 per cent), patients with coeliac disease only (88 per cent), and patients with insulin-dependent diabetes mellitus only (69 per cent), was significantly greater than in normal subjects (44 per cent). " 03/15/1983 - "The association of insulin-dependent (type I) diabetes mellitus with HLA-DR3 and DR4 and with several epidemiological, virological, immunological, and clinical data suggests a heterogenous pathogenesis. "
5.	Sarcoidosis (Schaumann Disease) 09/01/2004 - "Susceptibility to sarcoidosis and coeliac disease has been linked to the class II haplotype HLA-DR3, DQ2, and an association between the two disorders has been suggested. " 01/01/1992 - "Restricted V alpha 2.3 gene usage by CD4+ T lymphocytes in bronchoalveolar lavage fluid from sarcoidosis patients correlates with HLA-DR3." 08/01/1995 - "Findings that were essentially in agreement in both populations were: (1) a positive association of sarcoidosis with HLA-A1, B8, and DR3 markers, and a negative association with HLA-B12 and DR4; (2) a prevalence of HLA-DR3 and DR4 among females and of DR5 among males; (3) a relationship of B13 and B35 with early onset and of A30, B8, DR3, and DR4 with late onset of disease; (4) an association of B27 with sarcoidosis restricted to the lungs; (5) a relationship of A1, B8, B27, and DR3 to roentgenologic stage I and of B12 and DR4 to stage III; and (6) an association of HLA-DR3 with a good outcome. " 09/01/1983 - "The strong association between the acute, prognostically beneficial manifestation of sarcoidosis and HLA-DR3 might partly be related to the presence of circulating immune complexes in acute sarcoidosis as well as to an immunogenetically determined handling of a postulated etiological antigen."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	HLA-A1 Antigen (HLA A1 Antigen)
3.	Aurothioglucose (Gold 50)
4.	HLA-B12
5.	Hepatitis B e Antigens
6.	HLA-DR4 Antigen (HLA DR4 Antigen)
7.	Antibodies
8.	Antigens
9.	Insulin (Novolin)
10.	HLA-DR Antigens (HLA-DR)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Drug Therapy (Chemotherapy)
4.	Blood Transfusion (Blood Transfusions)
5.	Aftercare (After-Treatment)