HLA-B27 Antigen (HLA B27 Antigen)

Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is strongly associated with acute anterior uveitis (UVEITIS, ANTERIOR); ANKYLOSING SPONDYLITIS; and REACTIVE ARTHRITIS.

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Networked: 1591 relevant articles (22 outcomes, 150 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Inman, Robert D: 14 articles (01/2015 - 06/2003)
2.	Colbert, Robert A: 13 articles (06/2015 - 06/2002)
3.	Bowness, Paul: 12 articles (01/2015 - 01/2002)
4.	Sieper, Joachim: 12 articles (08/2014 - 01/2004)
5.	Reveille, John D: 11 articles (06/2015 - 06/2006)
6.	Sorrentino, Rosa: 11 articles (01/2014 - 05/2003)
7.	Taurog, Joel D: 10 articles (06/2015 - 01/2003)
8.	Sampaio-Barros, Percival D: 10 articles (01/2015 - 12/2003)
9.	López de Castro, José A: 10 articles (02/2014 - 10/2002)
10.	Mathieu, Alessandro: 9 articles (11/2014 - 05/2003)

Related Diseases

1.	Ankylosing Spondylitis 11/01/1992 - "The association of HLA-B27 with ankylosing spondylitis and related spondyloarthropathies has been known for two decades and has provided a great impetus to the epidemiologic studies and also helped broaden the clinical spectrum of these diseases. " 09/01/2014 - "To assess the gross intestinal colonoscopic changes and microscopic histopathologic findings of patients with ankylosing spondylitis; to correlate the colonoscopic and histopathologic findings; and to study the relationship of the histopathologic findings with extra-articular manifestations of the disease, HLA-B27, BASFI and BASDAI. " 05/01/2014 - "This study investigated the genetic polymorphisms of HLA-B27, together with polymorphisms on endoplasmic reticulum aminopeptidase 1 (ERAP1), and susceptibility for ankylosing spondylitis (AS) in the Beijing Han population. " 11/01/2013 - "The aim of the study was to investigate and compare the clinical manifestations between HLA-B27(+) and HLA-B27(-) ankylosing spondylitis (AS) patients in order to obtain knowledge of the impact of HLA-B27 status on AS, and to inform clinical treatment. " 10/01/2013 - "HLA-B27 homozygosity has no influence on radiographic damage in ankylosing spondylitis: Observation Study of Korean spondyloArthropathy Registry (OSKAR) data."
2.	Colitis 01/01/2012 - "Healthy, germ-free HLA-B27 transgenic (Tg) rats develop chronic colitis when colonized with complex gut commensal bacteria whereas non-transgenic (nTg) rats remain disease-free. " 03/01/2006 - "HLA-B27 transgenic (TG) rats develop spontaneous colitis when colonized with intestinal bacteria, whereas athymic nude (rnu/rnu) HLA-B27 TG rats remain disease free. " 07/01/2008 - "The aims of this study were to investigate bone loss in HLA-B27 transgenic rats, a spontaneous model of colitis and to compare the results provided by the usual markers of bone remodelling and by direct measurement of bone protein synthesis. " 03/01/2006 - "The present study was designed to determine whether or not HLA-B27 expression on T cells is required for development of colitis after transfer of mesenteric lymph node (MLN) cells into rnu/rnu HLA-B27 recipients. " 01/01/2012 - "theta induces colitis in HLA-B27 Tg rats, which is associated with regulation of bacterial genes in metabolic and nutrient binding pathways that may affect host immune responses. "
3.	Infection 07/01/2006 - "Studies have also focused on the consequences of the (rather inefficient) intracellular folding of the HLA-B27 heavy chain, the ability of cells to deal with intracellular infection, and their expression of unusual forms of HLA-B27 on cell surfaces (including free heavy chains and dimers). " 07/01/2002 - "It was the aim of this study to generate soluble HLA-B27 molecule and to analyze its effect on cytotoxic HLA-B27 alloreactive CD8+ T-lymphocytes in order to better understand potential functional links between persistent infection and HLA-B27 association. " 11/01/2001 - "In the present study, we have examined whether the expression of HLA-B27 can influence the infection of cell lines with C. " 11/01/2001 - "Previous studies report conflicting results concerning whether the presence of HLA-B27 modulates the infection of cells with these enteric pathogens. " 10/01/2000 - "The findings of this study also suggest a relation between infection with Bartonella species and HLA-B27."
4.	Uveitis 11/01/2015 - "We undertook this study to identify possible associations of KIR genotype with susceptibility to AS and disease characteristics including the presence of the HLA-B27 allele, disease severity, and uveitis. " 01/01/2015 - "Study subjects with uveitis were divided into two groups: 9 patients with idiopathic AAU and 11 patients with HLA-B27 associated AAU. " 07/01/2009 - "A blinded, controlled study of enthesis evident on ultrasound (US) examination was performed in 100 patients and controls classified into 5 groups, as follows: patients with confirmed SpA (group 1), patients with recurrent AAU who were positive for HLA-B27 and did not have SpA (group 2), patients with recurrent AAU who were negative for HLA-B27 and did not have SpA (group 3), patients with forms of uveitis other than those related to SpA (group 4), and healthy controls (group 5). " 09/01/2005 - "Although distinct features of HLA-B27 uveitis were confirmed in our study, visual outcome did not differ from idiopathic AAU. " 04/01/2004 - "Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases."
5.	Inflammation 11/01/2009 - "To use MRI to study the sacroiliac joint (SIJ) and lumbar spine (LS) and explore the relationship between sites and extent of inflammation and HLA-B27 status over 12 months. " 06/01/1999 - "This study compared the degree of gastrointestinal inflammation in gnotobiotic HLA-B27 transgenic rats monoassociated with either B. " 07/01/1995 - "Therefore, the objective of this study was to characterize quantitatively the GI injury and inflammation observed in commercially available HLA-B27 transgenic rats. " 01/01/2015 - "A predominant Th17-driven immune response may play an important role in the immunopathogenesis of idiopathic AAU, while Th1 dominant immune response may be responsible for the inflammation in HLA-B27 associated AAU." 01/01/2015 - "Ocular inflammation in HLA-B27 transgenic mice reveals a potential role for MHC class I in corneal immune privilege."

Related Drugs and Biologics

1.	HLA-B Antigens (HLA-B)
2.	Interleukin-10 (Interleukin 10)
3.	IS 741
4.	HLA Antigens (Human Leukocyte Antigens)
5.	oprelvekin (Neumega)
6.	Prednisolone (Predate)
7.	Dietary Calcium
8.	HLA-B57
9.	HLA-Bw62
10.	bacterial lysate

Related Therapies and Procedures

1.	Immunomodulation
2.	Transplantation (Transplant Recipients)
3.	Oral Administration
4.	Laser In Situ Keratomileusis (LASIK)
5.	Kidney Transplantation