HLA-B8 Antigen (HLA B8 Antigen)

Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is in linkage disequilibrium with HLA-A1 and HLA-DR3. This explains the fact that though HLA-B8 was originally associated with several diseases, including celiac disease, dermatitis herpetiformis, and myasthenia gravis, their association with HLA-DR3 is now considered more significant.

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Networked: 210 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Al-Attiyah, Rajaa: 1 article (09/2014)
2.	Al-Muzairai, Ibrahim: 1 article (09/2014)
3.	Mosaad, Youssef M: 1 article (09/2014)
4.	Abdul-Moneam, Mohamed: 1 article (09/2014)
5.	Mansour, Merveet: 1 article (09/2014)
6.	Shahin, Manal: 1 article (09/2014)
7.	Al-Otabi, Turky: 1 article (09/2014)
8.	Bjarnadottir, Kristjana: 1 article (09/2013)
9.	Gislason, Thorarinn: 1 article (09/2013)
10.	Petursdottir, Dyrleif: 1 article (09/2013)

Related Diseases

1.	Myasthenia Gravis 10/01/1998 - "Our results imply linkage disequilibrium of TNFbeta alleles with HLA-B8 and in myasthenia gravis we were unable to show a stronger association beyond HLA-B8." 08/01/1998 - "In a retrospective series of 86 patients with myasthenia gravis, the only factors predictive of improvement in muscular strength after transsternal thymectomy were preoperative severity of myasthenia (90% versus 54%, p = 0.0014) and HLA-B8 (79% versus 50%, p = 0.0060) in bivariable and multivariable analyses. " 04/01/1983 - "The observations also support those of others that HLA-B8 linked susceptibility gene is more frequently found in myasthenia gravis patients with thymic hyperplasia." 04/01/1983 - "HLA-B8 was increased nearly two fold in the myasthenia gravis patients (RR = 2.4) and was confined mainly to the young females without thymoma. " 06/01/1977 - "Recent studies have noted an increased association of the histocompatibility antigen HLA-B8 with myasthenia gravis in Caucasian patients. "
2.	Fibrosis (Cirrhosis) 06/01/1990 - "Remission (79% vs. 71%), relapse after drug withdrawal (76% vs. 71%), treatment failure (13% vs. 6%), progression to cirrhosis (46% vs. 32%), and death from liver failure (6% vs. 3%) occurred as frequently in patients with and without HLA-B8. " 05/01/1980 - "Men with alcoholic hepatitis with or without cirrhosis showed an increased incidence of the histocompatibility antigen HLA-B8 (P less than 0.02). " 06/19/1982 - "To test whether the increased prevalence of HLA-B8 reported in patients with alcoholic cirrhosis is due to the antigen being a genetic marker of susceptibility to liver damage from alcohol, patients who had cirrhosis of comparable clinical and histological severity were investigated for HLA-B8 status and cumulative alcohol intake. " 06/01/1990 - "To assess the clinical and prognostic implications of human leukocyte antigen B8 in corticosteroid-treated severe autoimmune chronic active hepatitis, 81 consecutive patients were tested for histocompatibility antigens on the A and B loci, treated with corticosteroids, and followed prospectively for 111 +/- 8 mo. The 47 patients with HLA-B8 were younger (38 +/- 2 yr vs. 48 +/- 2 yr; p less than 0.01), had higher serum levels of aspartate aminotransferase (658 +/- 60 U/L vs. 465 +/- 49 U/L; p = 0.02) and bilirubin (7 +/- 1 mg/dl vs. 2.8 +/- 0.4 mg/dl; p = 0.003), and more commonly had histologic features of bridging necrosis, multilobular necrosis, and cirrhosis (85% vs. 56%; p less than 0.01) at presentation than the 34 patients without HLA-B8. "
3.	Liver Failure 06/01/1990 - "Remission (79% vs. 71%), relapse after drug withdrawal (76% vs. 71%), treatment failure (13% vs. 6%), progression to cirrhosis (46% vs. 32%), and death from liver failure (6% vs. 3%) occurred as frequently in patients with and without HLA-B8. "
4.	Chronic Kidney Failure (Chronic Renal Failure) 09/01/2014 - "While the HLA-B8 antigen may be a susceptibility risk factor for development of ESRD, the HLA-A28, and HLA-DR11 antigens may be protective against development of ESRD in Kuwaiti population." 09/01/2014 - "The frequency of HLA-B8 antigen was significantly higher in ESRD patients (OR = 2.62, p = 0.001, pc = 0.038), and the frequency of HLA-A28, HLA-DR11 antigens was significantly higher in healthy controls (OR 0.42, p = 0.0001; pc = 0.0021, and OR = 0.44, p = 0.0007, pc = 0.01 respectively). "
5.	Graves Disease (Basedow Disease) 04/01/1983 - "This study demonstrates that Graves' disease can be subdivided using cluster analysis into clinically relevant subgroups which are further distinguished by their correlation with HLA-B8. " 09/01/1989 - "Our results demonstrate a strong association of the C4A*Q0 allele with Graves' disease (56 versus 26%; P less than 0.002, relative risk = 3.7) and in particular in association with HLA-B8 and/or DR3 (92 versus 70.6%; P less than 0.04) when compared with normal controls. " 01/01/1983 - "Our data confirm the previously described association of HLA-B8 and DR3 with Graves' disease, particularly in patients with ophthalmopathy. " 01/01/1981 - "Reduced C4 in HLA-B8 positive patients with Graves' disease." 02/01/1980 - "The haplotypes, identified in eight-six patients and 113 relatives, indicate that the excess of HLA-B8 in patients and their relatives is primarily due to the halpotype 1-8. The relative risk for an HLA-B8 individual of developing Graves' disease is 2.02, whilst the relative risk for an individual of haplotype 1-8 is 4.23. "

Related Drugs and Biologics

1.	Antigens
2.	HLA-A28
3.	HLA-DR11 antigen
4.	Histocompatibility Antigens (Histocompatibility Antigen)
5.	HLA Antigens (Human Leukocyte Antigens)
6.	HLA-B7 Antigen (HLA B7 Antigen)
7.	HLA-DR2 Antigen (HLA DR2 Antigen)
8.	HLA-Bw51
9.	HLA-B Antigens (HLA-B)
10.	HLA-DR3 Antigen (HLA DR3 Antigen)

Related Therapies and Procedures

1.	Thymectomy
2.	Aftercare (After-Treatment)
3.	Transplants (Transplant)
4.	Liver Transplantation
5.	Breast Implantation (Implantation, Breast)