Cytochromes b5 (Cytochrome b5)

Cytochromes of the b group that are found bound to cytoplasmic side of ENDOPLASMIC RETICULUM. They serve as electron carrier proteins for a variety of membrane-bound OXYGENASES. They are reduced by the enzyme CYTOCHROME-B(5) REDUCTASE.

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Networked: 201 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Barber, Michael J: 4 articles (11/2004 - 07/2003)
2.	Davis, C Ainsley: 4 articles (11/2004 - 07/2003)
3.	Sacco, James C: 3 articles (10/2012 - 01/2010)
4.	Trepanier, Lauren A: 3 articles (10/2012 - 01/2010)
5.	Jaffey, Jared A: 2 articles (07/2022 - 11/2019)
6.	Reading, N Scott: 2 articles (07/2022 - 11/2019)
7.	Baust, Jeffrey J: 2 articles (01/2022 - 12/2019)
8.	Durgin, Brittany G: 2 articles (01/2022 - 12/2019)
9.	Hahn, Scott A: 2 articles (01/2022 - 12/2019)
10.	Straub, Adam C: 2 articles (01/2022 - 12/2019)

Related Diseases

1.	Neoplasms (Cancer) 12/01/1983 - "The turnover of P-450 was not affected by the tumor, whereas cytochrome b5 turnover was decreased. " 07/01/2008 - "Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo)." 07/01/2008 - "We screened ferret adrenocortical tumor specimens for expression of cytochrome b(5) (cyt b(5)), an allosteric regulator that selectively enhances the 17,20-lyase activity of P450c17. " 03/01/1997 - "Concentrations of P450 total content, cytochrome b5, and NADPH-cytochrome c reductase showed parallel and marked reduction in tumor tissues when compared with its distant normal regions or normal livers. " 12/01/1992 - "This induction of GSH and GST, and depletion of cytochromes b5 and P450 by melatonin may possibly be related to its anticarcinogenic potential in this tumor model."
2.	Sarcoma (Soft Tissue Sarcoma) 12/01/1983 - "Extra-hepatic Walker sarcoma 256 produced a marked decrease (approximately 60%) in the levels of cytochrome P-450 and NADP-cytochrome P-450 reductase in rat liver endoplasmic reticulum, and a lesser decrease (approximately 20%) of cytochrome b5 and NADH-cytochrome b5 reductase. "
3.	Fibrosarcoma 01/01/2010 - "Reduction in tumor weight was noted in Group III as compared to II. The levels of cytochrome C in liver and kidney, the levels of cytochrome P450 and cytochrome b5 in liver microsomes, phase I biotransformation enzymes NADPH-cytochrome P450, NADPH-cytochrome b5, and aniline hydroxylase, and the phase II enzymes glutathione-S-transferase and UDP glucuronyl transferase indicated that their modulation played a role in the therapeutic efficacy of Indigofera aspalathoides against experimental fibrosarcoma."
4.	Methemoglobinemia 01/01/1986 - "Type II, generalized cytochrome B5 deficiency demonstrable in all of the tissues that have been examined, is accompanied by severe, lethal, progressive neurological disability, in addition to methemoglobinemia. " 03/01/2021 - "Erratum for Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats." 12/08/2020 - "Clinical, metabolic, and molecular genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in 30 dogs." 11/01/2019 - "Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats." 01/01/2018 - "As an outpatient, the patient underwent genetic testing and was diagnosed with homozygous cytochrome b5 reductase deficiency as the etiology of the methemoglobinemia. "
5.	Neuroblastoma 12/01/2015 - "In this study, in order to investigate how cytochrome b5 reductase (b5R), one of the PM redox enzymes, regulates cellular response under stressed conditions, human neuroblastoma cells transfected with b5R were used for viability and mitochondrial functional assays. " 01/01/2011 - "The effects of ellipticine in the presence of VPA and TSA on expression of CYPs and peroxidases relevant for ellipticine activation and levels of cytochrome b5 and P-glycoprotein in neuroblastoma cells were also investigated. " 01/01/2011 - "Based on these studies, we attribute most of the enhancing effects of VPA and TSA on ellipticine cytotoxicity to enhanced ellipticine-DNA adduct formation caused by an increase in levels of cytochrome b5, CYP3A4 and CYP1A1 in neuroblastoma cells. "

Related Drugs and Biologics

1.	Cytochrome P-450 Enzyme System (Cytochrome P450)
2.	NADP (NADPH)
3.	Enzymes
4.	Mixed Function Oxygenases (Monooxygenases)
5.	NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
6.	Glutathione Transferase (Glutathione S-Transferase)
7.	Hydrocarbons
8.	Cytochrome-B(5) Reductase (Methemoglobin Reductase)
9.	Cytochromes c (Cytochrome c)
10.	Glucuronosyltransferase (UDP Glucuronosyltransferase)

Related Therapies and Procedures

1.	Transplantation
2.	Ligation
3.	Castration