Betaxolol (Kerlon)

A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.

Also Known As:

Kerlon; Betoptic; ALO-1401-02; Betaxolol Alcon; Betaxolol Hydrochloride; Betoptima; Kerlone; Oxodal; SL-75212; ALO 1401 02; ALO140102; Alcon, Betaxolol; Hydrochloride, Betaxolol; SL 75212; SL75212; 2-Propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-

Networked: 302 relevant articles (28 outcomes, 67 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Heijl, Anders: 5 articles (11/2011 - 01/2003)
2.	Leske, M Cristina: 5 articles (11/2011 - 01/2003)
3.	Lu, Chun-Wei: 3 articles (02/2021 - 01/2018)
4.	Yen, Chi-Feng: 3 articles (02/2021 - 01/2018)
5.	Bengtsson, Boel: 3 articles (11/2011 - 11/2007)
6.	Whitson, Jess T: 3 articles (08/2009 - 12/2003)
7.	Hyman, Leslie: 3 articles (11/2007 - 01/2003)
8.	Cheon, Eun Woo: 3 articles (10/2003 - 09/2002)
9.	Cho, Gyeong Jae: 3 articles (10/2003 - 09/2002)
10.	Choi, Wan Sung: 3 articles (10/2003 - 09/2002)

Related Diseases

1.	Glaucoma 10/01/2001 - "In addition, two cases are reported of the occurrence of clinical depression following use of topical betaxolol which only resolved completely after switching glaucoma medication. " 01/01/2002 - "Betoptic S treatment in patients with open-angled glaucoma in early stages was efficient; therefore ocular pressure values continued in normal limits and visual capacity at automatic perimetry was improved. " 02/01/1995 - "Betaxolol appears to be an effective and well tolerated ocular hypotensive agent in a typical glaucoma population, which includes many patients with cardiopulmonary disease. " 08/01/1986 - "Betaxolol hydrochloride is a topical beta 1-blocking agent that has been found to be safe and effective in lowering intraocular pressure (IOP) in patients with glaucoma. " 01/01/2002 - "1. Betoptic S neuroprotector effect is obvious in early glaucoma patients; visual capacity was improved in all cases. "
2.	Hypertension (High Blood Pressure) 01/01/2004 - "The aim of this single-blind study was to compare the efficacy of betaxolol treatment (20 mg/day) on 24-h blood pressure profiles in working men and women with mild hypertension (grade 1 acc. " 01/01/1998 - "To study efficacy and tolerance of cardioselective beta-adrenoblocker lokren (betaxolol) in elderly patients with mild and moderate hypertension. " 04/01/1992 - "This study determined the dose-response relationship among three doses of betaxolol compared with placebo in patients with mild-to-moderate hypertension. " 07/01/1989 - "[Open trial of betaxolol in the treatment of arterial hypertension in pregnancy, pilot study]." 03/01/1983 - "[Dose-response study of betaxolol in arterial hypertension]."
3.	Ocular Hypertension (Glaucoma, Suspect) 03/01/2003 - "Results of the betaxolol versus placebo treatment trial in ocular hypertension." 01/01/1994 - "This study demonstrated that betaxolol increases RBF in eyes with ocular hypertension; this increase is probably related to the increase in perfusion pressure." 04/01/1984 - "Betaxolol, a new beta 1-adrenergic blocker, was applied to 20 eyes of ten patients with ocular hypertension. " 07/01/1990 - "Thus, betaxolol is an alternative therapeutic option available to the physician for the management of chronic open-angle glaucoma and ocular hypertension. " 03/01/2003 - "To determine whether treatment with betaxolol can delay or prevent the conversion from ocular hypertension to early glaucoma on the basis of visual field criteria, by means of a prospective, randomised, placebo-controlled trial. "
4.	Open-Angle Glaucoma (Glaucoma, Open Angle) 05/15/1986 - "Betaxolol appears to be a clinically effective and safe agent in the treatment of open-angle glaucoma. " 08/01/1995 - "Case #1 was a 47-year-old black man with primary open angle glaucoma, started on betaxolol 0.5% in both eyes in January 1981. " 07/01/1990 - "Thus, betaxolol is an alternative therapeutic option available to the physician for the management of chronic open-angle glaucoma and ocular hypertension. " 06/01/1998 - "Effect of betaxolol on primary open-angle glaucoma and normal-tension glaucoma patients." 07/01/1990 - "[Epidemiologic and tonometric results of a multicenter study of 5,872 patients with ocular hypertension or open-angle glaucoma treated with betaxolol]."
5.	Angina Pectoris 05/01/1990 - "The results indicate that betaxolol, in widely ranging doses, is highly effective in reducing angina pectoris frequency and improving exercise capacity in patients with stable exertional angina pectoris." 05/01/1990 - "Efficacy of betaxolol in the treatment of stable exertional angina pectoris: a dose-ranging study." 05/01/1990 - "To assess the efficacy of oral betaxolol in the treatment of stable exertional angina pectoris and to determine the relationship between betaxolol doses/serum concentrations and clinical/hemodynamic responses the authors studied 24 patients prior to and following stepwise administration of 5, 10, 20, 40, and 80 mg doses. " 05/01/1990 - "The mean doses of betaxolol required to produce a greater than or equal to 75% decrease in angina pectoris frequency and clinical beta blockade were 12 +/- 5 mg (range 5-40 mg) and 28 +/- 29 mg (range 5-80 mg) respectively. " 05/01/1990 - "Betaxolol produced a decrease in mean angina pectoris frequency from 6.6 +/- 1.9 episodes/week with placebo to 0.2 +/- 0.5 episode/week during clinical beta blockade (p less than 0.00005). "

Related Drugs and Biologics

1.	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)
2.	Brimonidine Tartrate (Alphagan)
3.	Timolol (Blocadren)
4.	Propranolol (Inderal)
5.	Suspensions
6.	Antipsychotic Agents (Antipsychotics)
7.	Lipids
8.	Sotalol (Sotalol Hydrochloride)
9.	Cytochrome P-450 CYP2D6 (CYP2D6)
10.	Levobunolol (AKBeta)

Related Therapies and Procedures

1.	Therapeutics
2.	Topical Administration
3.	Trabeculectomy (Trabeculoplasty)
4.	Radial Keratotomy
5.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)