Minor Histocompatibility Antigens

Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.

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Networked: 395 relevant articles (7 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Falkenburg, J H Frederik: 28 articles (01/2020 - 04/2002)
2.	Goulmy, Els: 21 articles (01/2015 - 01/2000)
3.	Dolstra, Harry: 19 articles (01/2018 - 10/2002)
4.	Kester, Michel G D: 13 articles (01/2018 - 03/2003)
5.	Riddell, Stanley R: 13 articles (03/2011 - 08/2002)
6.	Heemskerk, Mirjam H M: 11 articles (01/2020 - 03/2003)
7.	Hobo, Willemijn: 10 articles (01/2018 - 11/2010)
8.	Mutis, Tuna: 10 articles (12/2014 - 01/2002)
9.	Maas, Frans: 9 articles (01/2018 - 10/2002)
10.	Fredrix, Hanny: 9 articles (05/2015 - 10/2002)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2015 - "The therapeutic efficacy is based on donor-derived CD8(+) T cells that recognize minor histocompatibility antigens (MiHAs) expressed by patient's tumor cells. " 01/18/1982 - "The results show that in these conditions, the tumor graft could not transgress a minor histocompatibility antigen nor decrease the protective effects of polyoma virus against tumor challenge and that all the immune tests investigated were unaltered." 05/01/2010 - "Concomitant tumor and minor histocompatibility antigen-specific immunity initiate rejection and maintain remission from established spontaneous solid tumors." 07/15/2009 - "New studies show that tumor-reactive T cells are directed against diverse tumor-specific targets as well as minor histocompatibility antigens." 01/01/2022 - "We examined the role of cytolytic capacity on CD8+ T cell fate decisions when primed by tumor cells or by minor histocompatibility antigen-mismatched leukocytes. "
2.	Graft vs Host Disease (Graft-Versus-Host Disease) 03/15/2005 - "Mismatch for the adhesion molecule CD31 (PECAM-1) has been associated in some studies with graft-versus-host disease (GVHD), suggesting a role for CD31 as a minor histocompatibility antigen. " 01/01/1988 - "A well-characterized murine model of graft-vs-host disease (GVHD) that develops in response to minor histocompatibility antigens was used to study the mechanism of an immunodeficiency syndrome that is associated with GVHD. " 01/01/2021 - "Deciphering the role of Minor histocompatibility antigens for acute graft-versus-host disease." 01/01/2017 - "Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. " 01/01/2016 - "Graft-versus-host disease (GvHD), mediated by donor alloreactive T-cells in the graft, can be triggered by minor histocompatibility antigens in HLA-identical pairs, by alleles at loci not considered for MUD-matching or by the mismatched haplotype in haplo-HSCT. "
3.	Bronchiolitis Obliterans Syndrome 04/01/2005 - "Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission." 01/01/2022 - "However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory complications can occur, among which chronic graft-versus-host disease (cGVHD) can be life-threatening. " 10/01/1989 - "Hepatic lesions in murine chronic graft-versus-host disease to minor histocompatibility antigens. " 08/01/1983 - "Acute and chronic graft-versus-host disease induced by minor histocompatibility antigens in mice." 04/19/2004 - "We examined the immune response to DBY, a model H-Y minor histocompatibility antigen (mHA) in a male patient with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplant from a human histocompatibility leukocyte antigen (HLA)-identical female sibling. "
4.	Multiple Myeloma 02/01/2017 - "Efficacy of host-dendritic cell vaccinations with or without minor histocompatibility antigen loading, combined with donor lymphocyte infusion in multiple myeloma patients." 11/15/2010 - "Eradication of medullary multiple myeloma by CD4+ cytotoxic human T lymphocytes directed at a single minor histocompatibility antigen." 05/01/2007 - "Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene."
5.	Leukemia 04/01/2002 - "Recent studies in mice have shown that adoptive transfer of primed T cells targeted to a single major histocompatibility complex class I restricted immunodominant minor histocompatibility antigen can eradicate leukemia cells without causing any toxicity to the host. " 03/03/2023 - "The T cell immune response to minor histocompatibility antigens (MiHAs) promotes a favorable graft-versus-leukemia response. " 01/01/2023 - "Shared graft-versus-leukemia minor histocompatibility antigens in DISCOVeRY-BMT." 01/01/2020 - "H60: A Unique Murine Hematopoietic Cell-Restricted Minor Histocompatibility Antigen for Graft-versus-Leukemia Effect." 01/01/2018 - "Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens."

Related Drugs and Biologics

1.	16-iodo-3-methylhexadecanoic acid (MIHA)
2.	Chloroquine (Aralen)
3.	Amines
4.	Minor Histocompatibility Antigens
5.	Histocompatibility Antigens (Histocompatibility Antigen)
6.	Endotoxins
7.	Antigens
8.	Peptides (Polypeptides)
9.	HLA Antigens (Human Leukocyte Antigens)
10.	Vaccines

Related Therapies and Procedures

1.	Therapeutics
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
3.	Transplantation
4.	Immunotherapy
5.	Cell Transplantation