Diffuse Palmoplantar Keratoderma (Tylosis)

An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.

Also Known As:

Networked: 28 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Esophageal Neoplasms (Esophageal Cancer)
3.	Keratosis
4.	Wolf-Hirschhorn Syndrome
5.	Wounds and Injuries (Trauma)

Experts

1.	Risk, Janet M: 4 articles (01/2012 - 05/2004)
2.	McRonald, Fiona E: 4 articles (01/2012 - 05/2004)
3.	Field, John K: 3 articles (07/2006 - 05/2004)
4.	Kelsell, David P: 2 articles (06/2010 - 05/2004)
5.	Liloglou, Triantafillos: 2 articles (07/2006 - 04/2006)
6.	Xinarianos, George: 2 articles (07/2006 - 04/2006)
7.	Ellis, Anthony: 2 articles (04/2006 - 05/2004)
8.	Shaw, Joan M: 2 articles (04/2006 - 05/2004)
9.	Rowbottom, Lynn: 2 articles (04/2006 - 05/2004)
10.	Langan, Joanne E: 2 articles (04/2006 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diffuse Palmoplantar Keratoderma:

1.	Hyperkeratosis of the palms and soles and esophageal papillomasIBA 04/15/2006 - "Tylosis (focal non-epidermolytic palmoplantar keratoderma) is an autosomal dominant skin disorder that is associated with the early onset of squamous cell oesophageal cancer (SCOC) in three families. " 05/01/2004 - "Tylosis (focal non-epidermolytic palmoplantar keratoderma) is associated with the early onset of squamous cell oesophageal cancer in three families. " 01/01/1999 - "Tylosis (focal non-epidermolytic palmoplantar keratoderma; NEPPK) is associated with esophageal cancer in three families, two of which contain six or seven generations. " 04/10/2003 - "Moreover, a locus responsible for hereditary focal non-epidermolytic palmoplantar keratoderma (tylosis oesophageal cancer; TOC), a condition associated with esophageal cancer, has been mapped to the same band. " 04/01/2001 - "Moreover, a genetic locus for hereditary focal non-epidermolytic palmoplantar keratoderma, a condition associated with cancer of the esophagus (TOC; Tylosis with Oesophageal Cancer), lies in the same region. "
2.	cytoglobinIBA 01/01/2012 - "Cytoglobin is a candidate for the tylosis with oesophageal cancer gene, and its expression is strongly down-regulated in non-cancerous oesophageal biopsies from patients with TOC compared with normal biopsies. " 07/01/2006 - "One candidate tumour-suppressor gene is cytoglobin (CYGB), which is contained entirely within the 42.5 kb tylosis with oesophageal cancer (TOC) minimal region. " 04/15/2006 - "Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression."
3.	Keratin-1IBA 09/01/2009 - "Mutation L437P in the 2B domain of keratin 1 causes diffuse palmoplantar keratoderma in a Chinese pedigree." 01/01/2006 - "A novel mutation and large size polymorphism affecting the V2 domain of keratin 1 in an African-American family with severe, diffuse palmoplantar keratoderma of the ichthyosis hystrix Curth-Macklin type."
4.	Mal de MeledaIBA 01/01/2015 - "SLURP1 is the causal gene for Mal de Meleda (MDM), an autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma and transgressive keratosis. " 01/01/2003 - "Mal de Meleda (MDM) or keratosis palmoplantaris transgrediens of Siemens is an autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma (PPK) and transgressive keratosis with an onset in early infancy. "
5.	envoplakinIBA 11/01/1996 - "Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25." 04/01/2005 - "Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas."
6.	Keratin-9 (Keratin 9)IBA 10/01/2005 - "The mutation G485A found in keratin 9 gene is the disease-causing mutation in the diffuse palmoplantar keratoderma family." 10/01/2005 - "[Hotspot of the mutations of keratin 9 gene in a diffuse palmoplantar keratoderma family]."
7.	Nonsense Codon (Nonsense Mutation)IBA 06/01/2010 - "We describe homozygous nonsense mutation, p.S24X, and homozygous splice site mutation, c.468G>A, in the JUP gene that results in skin fragility, diffuse palmoplantar keratoderma, and woolly hair with no symptoms of cardiomyopathy. "
8.	Vitamin A (Retinol)FDA LinkGeneric 11/30/1963 - "SERUM-VITAMIN-A LEVELS IN TWO FAMILIES WITH TYLOSIS."
9.	LyeIBA 12/01/1989 - "These conditions include achalasia, Barrett's esophagus, chronic atrophic gastritis with intestinal metaplasia, familial polyposis coli, gastric polyps, lye stricture, Plummer-Vinson syndrome, and tylosis. "
10.	Glutamine (L-Glutamine)FDA Link 10/01/2005 - "We found a G485A transition in ke ratin 9 gene, resulting in the substitution of glutamine for arginine at codon 162 in this diffuse palmoplantar keratoderma family. "