2-Chloroadenosine (2 Chloroadenosine)

2-Chloroadenosine. A metabolically stable analog of adenosine which acts as an adenosine receptor agonist. The compound has a potent effect on the peripheral and central nervous system.

Also Known As:

Networked: 102 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Willems, Laura: 3 articles (01/2007 - 07/2002)
2.	Headrick, John P: 3 articles (01/2007 - 07/2002)
3.	Bache, Robert J: 2 articles (08/2009 - 10/2008)
4.	French, Joel: 2 articles (08/2009 - 10/2008)
5.	Hu, Xinli: 2 articles (08/2009 - 10/2008)
6.	Chen, Yingjie: 2 articles (08/2009 - 10/2008)
7.	Zhu, Guangshuo: 2 articles (08/2009 - 10/2008)
8.	Xu, Xin: 2 articles (08/2009 - 10/2008)
9.	Schnermann, Jurgen: 2 articles (10/2008 - 02/2005)
10.	Ashton, Kevin J: 2 articles (01/2007 - 02/2005)

Related Diseases

1.	Seizures (Seizure) 03/05/1991 - "Lower doses of 2-chloroadenosine provided significant protection against audiogenic seizures (66 and 331 pmol) when injected into the inferior colliculus. " 03/05/1991 - "2-Chloroadenosine infusion into the substantia nigra pars reticulata provided significant protection against electroshock seizures (1.66, 8.33 and 25 nmol) and audiogenic seizures (66, 331 pmol and 1.66 nmol). " 11/01/2010 - "Minimal clonic seizures in 18-day and older rats were suppressed by high doses of 2-chloroadenosine. " 11/01/2010 - "Nonspecific receptor agonist 2-chloroadenosine was tested against pentetrazol-induced convulsions in immature (7, 12, 18 and 25 days old) and adult rats. " 07/01/2005 - "Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application."
2.	Self Mutilation 02/01/1988 - "After systemic administration of SKF-38393 or L-dopa, central microinjection of the adenosine agonists, 2-chloroadenosine or 5'-N-ethylcarboxamide adenosine, were effective in preventing self mutilation induced by these dopamine agonists in neonatally lesioned rats. "
3.	Ischemia 01/01/1997 - "2-Chloroadenosine (0.6 mg/kg, IV) was administered 5 min subsequent to ischemia. " 06/01/1993 - "This study evaluated the effects of an adenosine analogue, 2-chloroadenosine (2CA), on ischemia-reperfusion (IR) injury in rabbit lungs. " 07/01/2002 - "Coronary responses were selectively reduced: 2-chloroadenosine and ADP dilated with pEC(50)s of 8.4+/-0.1 and 7.4+/-0.1 in non-ischemic hearts versus 7.7+/-0.1 and 7.1+/-0.1 after 20-min ischemia (P<0.05). " 01/01/1996 - "3. It is concluded that 2-chloroadenosine treatment influenced ATP production and Na,K ATPase activity in ischemia and reperfusion (P < 0.05)." 01/01/1996 - "The effect of 2-chloroadenosine, an adenosine analogue, on brain ATP level and Na,K ATPase activity in ischemia and reperfusion was studied. "
4.	Neoplasms (Cancer) 02/11/2000 - "Furthermore, the administration of 2-chloroadenosine following the tumor cell challenge had little effect on the metastatic potential. " 02/11/2000 - "Treatment of mice with 2-chloroadenosine prior to the tumor cell challenge cancelled the suppression of not only metastasis but also the lung accumulation. " 11/01/1994 - "In this study we show that 2-chloroadenosine (2CA), a stable analogue of adenosine, inhibits, in a dose-dependent fashion, MHC-unrestricted killing of P815 tumor target cells by anti-CD3-activated killer (AK) lymphocytes. " 03/01/1988 - "The metastatic capacity of murine mammary tumor line 410.4 is greatly increased by treatment of the host with asialo-GM1 antiserum (5-fold), 2-chloroadenosine (4-fold) or k-carrageenan (2.5-fold). " 10/01/2008 - "Moreover, 2-Chloroadenosine is capable of modulating PAR-1 and IL-23 gene expression suggesting a modulation of cancer metastasis and immune system activity. "
5.	Bone Resorption 05/25/1983 - "Studies on the mechanisms by which 2-chloroadenosine stimulates bone resorption in tissue culture." 05/25/1983 - "The results suggest that 2-chloroadenosine stimulated bone resorption by a process which is dependent on osteoclastic activity. " 05/25/1983 - "The effect of 2-chloroadenosine on bone resorption was studied in calvarial bones from 6-7-day-old mice in organ culture. " 04/01/1985 - "These data suggest that 2-chloroadenosine can induce bone resorption by a mechanism independent of stimulation of prostaglandin synthesis but that the amount of 2-chloroadenosine stimulated resorption is enhanced by endogenous and exogenous PGE2." 04/01/1985 - "Prostaglandin E2 and 2-chloroadenosine act in concert to stimulate bone resorption in cultured murine calvarial bones."

Related Drugs and Biologics

1.	Adenosine
2.	Purinergic P1 Receptors (Adenosine Receptor)
3.	Pentylenetetrazole (Metrazol)
4.	N(6)-cyclohexyladenosine
5.	Purinergic P1 Receptor Agonists
6.	Aminophylline (Carine)
7.	Phenobarbital (Luminal)
8.	Benzodiazepines
9.	methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate
10.	Dopamine Agonists (Dopamine Agonist)

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Intravenous Injections
3.	Injections
4.	Anesthesia