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Alfentanil (Alfenta)

A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.

Also Known As:

Alfenta; Alfentanil Hydrochloride; Esteve Brand of Alfentanil Hydrochloride; Fanaxal; ICI Brand of Alfentanil Hydrochloride; Janssen Brand of Alfentanil Hydrochloride; Limifen; R-39209; Rapifen; R 39209; R39209; Alfentanyl; Propanamide, N-(1-(2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl)-4-(methoxymethyl)-4-piperidinyl)-N-phenyl-

Networked: 531 relevant articles (42 outcomes, 84 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperidines: 12
    - Fentanyl: 4324
      - Alfentanil: 531

Experts

1.	Kharasch, E D: 5 articles (04/2012 - 12/2001)
2.	Stener-Victorin, Elisabet: 4 articles (05/2010 - 07/2002)
3.	Dahan, Albert: 3 articles (09/2014 - 07/2005)
4.	Hwang, Jung-Won: 3 articles (09/2013 - 02/2009)
5.	Turhanoglu, Selim: 3 articles (04/2013 - 12/2004)
6.	London, A: 3 articles (04/2012 - 04/2011)
7.	Kim, T: 3 articles (04/2012 - 04/2011)
8.	Kim, J Y: 3 articles (07/2010 - 05/2009)
9.	Kwak, H J: 3 articles (07/2010 - 05/2009)
10.	Hoffer, Christine: 3 articles (10/2005 - 03/2003)

Related Diseases

1.	Pain (Aches) 02/01/2012 - "A prospective, non-randomized, questionnaire-based study of the experience, satisfaction and pain scores of consecutive patients undergoing oculoplastic procedures under local anaesthesia with alfentanil sedation at University Hospital, Coventry, UK, under the care of one Consultant Oculoplastic Surgeon between 2006 and 2009. " 01/01/2011 - "This study will provide evidence whether a single bolus intravenous alfentanil gives a clinically relevant reduction in maximum pain during CT colonography. " 03/01/2001 - "The effects of alfentanil on cold and cold pain thresholds and spontaneous pain scores correlates with previous studies suggesting an opiate central analgesic effect. " 11/01/1993 - "Pain is quantified by the patient on a numerical scale of 1 to 10 at 1.5-min intervals during Phase 1 and 9-min intervals during Phase 2. In simulation trials in which a fixed approximate model was used for the effect of sedation on pain while the pharmacokinetics of alfentanil were varied from one simulated patient to another, zero pain was achieved in under 15 min with minimal overshoot in plasma drug concentration and was maintained, with only minor deviation, by means of low drug concentrations." 01/01/2014 - "In both pain models, alfentanil was administered in fixed-dose fractions of the 50% effective dose (ED50), and the types of interactions were determined by isobolographic analysis. "
2.	Postoperative Pain 02/01/2012 - "This study was designed to evaluate whether the combination of sciatic nerve blockade (SNB) and intravenous alfentanil (IVA) is more effective than either single treatment in relieving postoperative pain in rats. " 10/01/1996 - "This study was designed to compare the efficacy of epidural vs. intravenous administration of alfentanil for treatment of postoperative pain. " 06/01/1994 - "This study was designed to compare the efficacy and serum concentrations of alfentanil given subcutaneously (SQ) or epidurally (EPID) for treatment of postoperative pain. " 02/01/2012 - "Combination of nerve blockade and intravenous alfentanil is better than single treatment in relieving postoperative pain." 10/01/2008 - "Patients in Groups LK and LDK required less alfentanyl for control of intraoperative and early postoperative pain. "
3.	Vomiting 08/01/1993 - "Vomiting after alfentanil anesthesia." 10/01/1992 - "Vomiting after alfentanil anesthesia: effect of dosing method." 06/01/1990 - "The purpose of this study was to examine three anesthetic techniques utilizing alfentanil with regard to time to awakening, time to orientation and incidence of nausea and vomiting. " 12/01/2000 - "Vomiting and nausea with alfentanil was noted in three patients. " 03/01/1997 - "Variables measured were intraoperative alfentanil requirements, time until extubation, presence and intensity of pain in the immediate postoperative period and incidence of vomiting. "
4.	Burns 11/01/1992 - "The volume of distribution and total clearance of alfentanil were reduced significantly in the burns group. " 11/01/1992 - "Disposition of alfentanil in burns patients." 12/01/2000 - "Median (range) total dose of alfentanil was 2.6 (1-10.7) mg. This study supports the efficacy of an operator-adjusted target-controlled infusion of alfentanil to provide analgesia for burn dressing changes." 12/01/2000 - "This study aimed to determine whether an operator-adjusted target-controlled infusion of alfentanil could provide effective analgesia for burn dressing changes. " 12/01/2000 - "The use of a target-controlled infusion of alfentanil to provide analgesia for burn dressing changes A dose finding study."
5.	Nausea 06/01/1990 - "The purpose of this study was to examine three anesthetic techniques utilizing alfentanil with regard to time to awakening, time to orientation and incidence of nausea and vomiting. " 03/01/2005 - "One patient in group II had nausea and another one patient displayed hypoxemia after alfentanil administration. " 12/01/2000 - "Vomiting and nausea with alfentanil was noted in three patients. " 05/01/1996 - "One patient experienced nausea but no vomiting, no other adverse effects of alfentanil were noted. " 10/01/1992 - "We conclude that alfentanil infusion for laparoscopic surgery entails a high risk for nausea and vomiting."

Related Drugs and Biologics

1.	Propofol (Diprivan)
2.	Fentanyl (Sublimaze)
3.	Ketamine
4.	Lidocaine (Xylocaine)
5.	remifentanil (Ultiva)
6.	Midazolam (Versed)
7.	Morphine (MS Contin)
8.	Droperidol
9.	Methohexital (Brevital)
10.	Dexmedetomidine

Related Therapies and Procedures

1.	Anesthesia
2.	Analgesia
3.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
4.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
5.	Intravenous Infusions