Foreign-Body Granuloma (Granuloma, Foreign Body)

Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.

Also Known As:

Networked: 284 relevant articles (4 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Ankylosis
2.	Essential Osteolysis
3.	Erythema
4.	Granuloma
5.	Neoplasms (Cancer)

Experts

1.	Klinge, U: 5 articles (08/2014 - 12/2008)
2.	Binnebösel, M: 5 articles (05/2012 - 12/2008)
3.	Klinge, Uwe: 4 articles (01/2015 - 04/2007)
4.	Junge, K: 4 articles (05/2012 - 12/2008)
5.	Klink, C D: 4 articles (05/2012 - 02/2010)
6.	Otto, J: 3 articles (05/2012 - 02/2010)
7.	Schumpelick, V: 3 articles (01/2011 - 12/2008)
8.	Romanelli, Paolo: 2 articles (05/2015 - 01/2008)
9.	Wang, W: 2 articles (02/2015 - 05/2014)
10.	Guan, X: 2 articles (02/2015 - 05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Foreign-Body Granuloma:

1.	HormonesIBA 09/01/1992 - "We thought that the steroid hormone elicited good results in the treatment of inoperable foreign-body granuloma." 09/01/1992 - "[A case of foreign-body granuloma treated with steroid hormone]." 07/01/1954 - "II. Evolution of a foreign body granuloma (plant charcoal) in white mice treated with somatotropic hormone]."
2.	baysilon (polydimethylsiloxane)IBA 01/01/2002 - "Silastic removal was necessary in five cases due to its inducement of foreign body granuloma. " 01/01/2002 - "In our opinion the gold standard surgery of TMJ ankylosis today is represented by shaving of articular surfaces and subsequent arthroplasty with or without temporal muscle myofascial flap interposition, whereas the use of Silastic as alloplastic material could be associated to an increased persistence of the local symptoms and a higher risk of foreign body granuloma and it may favor ankylosis relapse and hinder rehabilitation." 09/01/1992 - "Eighteen cartilage grafts placed after Proplast (Vitek, Inc, Houston, TX) or Silastic (Dow Corning, Midland, MI) implants had been removed, all showed foreign-body granuloma with coexistent intact cartilage grafts. "
3.	Polyethylene (Polythene)IBA 12/01/2013 - "This mass was a foreign body granuloma formed secondary to the polyethylene wear debris due to the instability of the polyethylene in the metal shell. " 05/01/2000 - "Foreign-body granulomas containing HDPE particles were seen at the bone-implant interface in animals given 10(8) particles. " 01/01/1997 - "This study demonstrates that polyethylene wear products alone can cause massive osteolysis by triggering the formation of foreign body granuloma at the bone-implant interface." 01/01/1999 - "Small particles of ultrahigh molecular weight polyethylene stimulate formation of foreign-body granulomas and bone resorption. "
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/01/1994 - "Based on the finding of foreign body granulomas and an increased number of alveolar macrophages, we propose a hypothetical pathway for the development of this unusual reaction to PC infection focusing on the possible secretion of tumor necrosis factor alpha by activated macrophages. " 10/01/1995 - "The present study examined the temporal pattern and localization of interleukin-1, tumor necrosis factor-alpha, and inducible nitric oxide synthase expression in lung tissue undergoing foreign body granuloma formation. " 11/01/2000 - "These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes, MMP-2 and MMP-9, suggesting that TNF-alpha may induce MMP production followed by matrix degradation within foreign body granulomas. "
5.	CelluloseIBA 01/01/1977 - "Of 7,500 surgical specimens and autopsies from surgical mortalities reviewed by one pathologist during a two and a half year study period, forty-five cases of cellulose foreign body granulomas were identified by light microscopy. " 02/01/1981 - "The cellulose crystals induced foreign body granulomas when extravasated subcutaneously at injection sites on the arms, as well as in the right ventricular endocardium. " 01/01/1977 - "This suggests that cellulose foreign body granuloma may be a significant cause of intestinal obstruction. "
6.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 10/01/1995 - "The present study examined the temporal pattern and localization of interleukin-1, tumor necrosis factor-alpha, and inducible nitric oxide synthase expression in lung tissue undergoing foreign body granuloma formation. "
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/01/2005 - "The present study investigated the effect of VEGF antagonism on blood vessels of foreign-body granulomas (a model of wound-healing tissue). "
8.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 03/01/2007 - "Immunological studies showed a positive PR3-ANCA (c-ANCA) test, and skin biopsy of the crural erythema showed foreign body granuloma. "
9.	Interleukin-1 (Interleukin 1)IBA 10/01/1995 - "The present study examined the temporal pattern and localization of interleukin-1, tumor necrosis factor-alpha, and inducible nitric oxide synthase expression in lung tissue undergoing foreign body granuloma formation. "
10.	ultra-high molecular weight polyethylene (UHMWPE)IBA 09/01/1990 - "The results of this study demonstrate that UHMWPE wear products alone can cause massive osteolysis by triggering foreign-body granuloma formation at the bone-cement interface; the bone cement may remain fixed in areas beyond the osteolytic transformation."

Therapies and Procedures

1.	Debridement 01/01/2006 - "Foreign body granuloma and fistulation occurred in 1 (9%) member of the study group, but was treated successfully with debridement; implant palpability subsided after 24 months. " 08/01/2007 - "Through debridement and decompression of neural structures and chronic damage caused by foreign body granulomas can be prevented. "
2.	Arthroplasty 12/01/2013 - "The patient underwent successful revision hip arthroplasty after the removal of the foreign body granuloma. " 02/01/2007 - "Removal of an intrapelvic foreign body granuloma and rerevision hip arthroplasty had to be performed within 2 years after the first revision." 01/01/2002 - "In our opinion the gold standard surgery of TMJ ankylosis today is represented by shaving of articular surfaces and subsequent arthroplasty with or without temporal muscle myofascial flap interposition, whereas the use of Silastic as alloplastic material could be associated to an increased persistence of the local symptoms and a higher risk of foreign body granuloma and it may favor ankylosis relapse and hinder rehabilitation."
3.	Rhinoplasty 10/01/2011 - "Efficacy of open rhinoplasty approach to foreign body granuloma of the nose."
4.	Injections 07/01/2012 - "The purpose of the study was to present the clinical and microscopic features of oral foreign body granulomas associated with the injectable dermal filler Radiesse, and to increase awareness of this potential complication as the use of dermal fillers by the aging Baby Boom generation increases. " 03/01/2015 - "Foreign body granulomas can be treated effectively with intralesional corticosteroid injections. " 06/01/2009 - "Foreign body granulomas occur at certain rates with all injectable dermal fillers. " 06/01/2009 - "Foreign body granulomas after all injectable dermal fillers: part 2. Treatment options." 06/01/2009 - "Foreign body granulomas after all injectable dermal fillers: part 1. Possible causes."
5.	Sutures (Suture) 01/01/2014 - "Finally, it was confirmed as a foreign-body granuloma encasing surgical suture and adipose tissue by the pathological analysis. " 10/01/2011 - "Intracranial foreign body granuloma caused by dural tenting suture." 03/01/2011 - "We conclude that the use of absorbable suture materials should be considered in flexor tendon repair, as outcomes are not dissimilar and may avoid such foreign body granulomas." 01/01/2011 - "In the absence of tension, sutures were surrounded by a foreign body granuloma with an inflammatory infiltrate not encircling the fibre but forming almost symmetric comet-tail-like infiltrates on opposite sides. " 04/01/2010 - "All animals developed foreign body granulomas around the sutures. "