Nisoldipine

A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.

Also Known As:

Networked: 330 relevant articles (48 outcomes, 77 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Schwedhelm, Edzard: 4 articles (10/2007 - 09/2006)
2.	Benndorf, Ralf A: 4 articles (10/2007 - 09/2006)
3.	Maas, Renke: 4 articles (10/2007 - 09/2006)
4.	Appel, Daniel: 4 articles (10/2007 - 09/2006)
5.	Böger, Rainer H: 3 articles (10/2007 - 09/2006)
6.	Jiang, Ru: 2 articles (01/2010 - 01/2009)
7.	Chen, Hui: 2 articles (01/2010 - 01/2009)
8.	Silberhorn, Elisabeth: 2 articles (04/2007 - 09/2006)
9.	White, William B: 2 articles (04/2007 - 09/2003)
10.	Schulze, Friedrich: 2 articles (03/2007 - 09/2006)

Related Diseases

1.	Ischemia 08/01/1985 - "The rate-pressure product was significantly greater with nisoldipine than with placebo at the onset of ischemia and at peak exercise (22.8 +/- 1.1 versus 20 +/- 1.4 X 10(3) U for the 20 mg dose; p less than 0.01). " 03/15/1991 - "The results indicate that nisoldipine was effective in improving all exercise parameters and only partially effective in suppressing ischemia during daily activity." 01/01/1989 - "[Protective effects of m-nisoldipine and nisoldipine on myocardial damage in working rabbit hearts after ischemia-reperfusion]." 07/01/1992 - "The improved functional recovery of reperfused myocardium in dogs pretreated with nisoldipine cannot be attributed to an increased regional myocardial blood flow during ischemia or reperfusion. " 01/01/1989 - "We assessed the efficacy of nisoldipine in the treatment of asymptomatic ischemia in 12 patients with chronic, stable angina. "
2.	Hypertension (High Blood Pressure) 01/01/1999 - "Nisoldipine coat-core (nisoldipine CC), an extended-release once-daily formulation, is an effective treatment for mild-to-moderate hypertension, providing sustained blood pressure control over the 24-hour dosing interval. " 07/01/1990 - "We conclude that Nisoldipine is safe and effective in the treatment of mild essential hypertension." 09/01/1997 - "Canadian Nisoldipine CC Hypertension Trial Group." 03/01/1997 - "Efficacy and tolerability of nisoldipine coat-core formulation in the treatment of essential hypertension: The South African Multicenter ANCHOR Study. " 04/01/1996 - "Twenty-four patients completed a dose ranging study of the effect of nisoldipine as monotherapy in the treatment of hypertension. "
3.	Angina Pectoris 11/01/1996 - "The purpose of the study was to evaluate the onset and duration of antianginal and anti-ischemic efficacy of a single oral dose of nisoldipine compared with placebo in patients with stable angina pectoris. " 11/01/1996 - "Antianginal and anti-ischemic efficacy of nisoldipine in stable angina pectoris: a randomized, double-blind, placebo-controlled trial." 04/27/1995 - "In patients with angina pectoris, nisoldipine CC improved total treadmill exercise duration (p = 0.027), delayed the onset of angina pectoris (p = 0.009), and increased time to exercise-induced ST-segment depression (p = 0.061). " 06/15/1994 - "Antianginal and anti-ischemic efficacy of immediate-release nisoldipine in chronic stable angina pectoris." 11/01/1996 - "In 33 patients with stable angina pectoris, nisoldipine was tested (10 mg daily) in a randomized, double-blind, placebo-controlled study. "
4.	Coronary Artery Disease (Coronary Atherosclerosis) 11/01/1989 - "The prolonged efficacy of nisoldipine could be favourable in oral long-term treatment of patients with coronary artery disease." 12/01/1985 - "These data demonstrated improved rest and exercise cardiac performance following nisoldipine in patients with severe coronary artery disease." 08/01/2003 - "The NICOLE study (NIsoldipine in COronary artery disease in LEuven) is a single centre, randomised, double blind, placebo controlled trial with coronary angiography at baseline, six months, and three years of follow up. " 08/01/2003 - "Long term effects of nisoldipine on the progression of coronary atherosclerosis and the occurrence of clinical events: the NICOLE study." 08/01/2003 - "Nisoldipine has no demonstrable effect on the angiographic progression of coronary atherosclerosis or the risk of major cardiovascular events but its use is associated with fewer revascularisation procedures."
5.	Myocardial Infarction 01/01/1997 - "DEFIANT-II: a study of nisoldipine CC after myocardial infarction. " 01/01/1997 - "The DEFIANT studies have demonstrated that nisoldipine CC improves cardiac function and exercise tolerance in patients recovering from acute myocardial infarction, without increasing the risk of mortality compared with placebo. " 01/01/1997 - "A multicentre, double-blind, placebo-controlled trial was conducted in 542 patients, randomized 7-10 days after myocardial infarction, to study the effect of nisoldipine coat-core (nisoldipine-CC) on exercise after 6 months. " 04/27/1995 - "In the Doppler Flow and Echocardiography in Functional Cardiac Insufficiency: Assessment of Nisoldipine Therapy (DEFIANT-I) study of patients recovering from myocardial infarction, nisoldipine CC had a salutary effect on diastolic ventricular function, with a higher transmitral early filling velocity and shorter isovolumic relaxation time than in patients receiving placebo. " 04/27/1995 - "The aim of the present study was to evaluate whether oral nisoldipine can increase regional myocardial blood flow (MBF) in dyssynergic but viable myocardium after myocardial infarction. "

Related Drugs and Biologics

1.	Calcium
2.	Nifedipine (Adalat)
3.	1,4-dihydropyridine (dihydropyridine)
4.	Calcium Channels (Calcium Channel)
5.	Amlodipine (Norvasc)
6.	Calcium Channel Blockers (Blockers, Calcium Channel)
7.	Nitrendipine
8.	Atenolol (Tenormin)
9.	Enalapril
10.	Diltiazem (Cardizem)

Related Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal)
2.	Microelectrodes
3.	Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)
4.	Aftercare (After-Treatment)
5.	Intravenous Injections