Felodipine (Agon)

A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
Also Known As:
Agon; 1A Brand of Felodipine; AbZ Brand of Felodipine; Aliud Brand of Felodipine; Alphapharm Brand of Felodipine; Alpharma Brand of Felodipine; Astra Brand of Felodipine; AstraZeneca Brand of Felodipine; Aventis Brand of Felodipine; Azupharma Brand of Felodipine; BC Brand of Felodipine; Felo Biochemie; Felo-Puren; Felobeta; Felocor; Felodipin 1A Pharma; Felodipin AL; Felodipin AZU; Felodipin AbZ; Felodipin Heumann; Felodipin Stada; Felodipin dura; Felodipin-ratiopharm; Felodur; Felogamma; Fensel; Flodil; H 154-82; Heumann Brand of Felodipine; Hexal Brand of Felodipine; Hoechst Brand of Felodipine; Merck dura Brand of Felodipine; Modip; Munobal; Perfudal; Pharmaceutica Astra Brand of Felodipine; Pharmacia Spain Brand of Felodipine; Plendil; Promed Brand of Felodipine; Renedil; Stadapharm Brand of Felodipine; TheraPharm Brand of Felodipine; Wörwag Brand of Felodipine; betapharm Brand of Felodipine; ct-Arzneimittel Brand of Felodipine; felodipin von ct; ratiopharm Brand of Felodipine; Felo Puren; Felodipin ratiopharm; H 154 82; H 15482; Heumann, Felodipin; ct Arzneimittel Brand of Felodipine; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
Networked: 514 relevant articles (58 outcomes, 141 trials/studies)

Relationship Network

Drug Context: Research Results


1. FEVER Study Group: 3 articles (06/2011 - 12/2005)
2. Liu, Lisheng: 3 articles (06/2011 - 12/2005)
3. Zhang, Xuezhong: 3 articles (06/2011 - 12/2005)
4. Zanchetti, Alberto: 3 articles (06/2011 - 12/2005)
5. Zhang, Yun: 3 articles (09/2008 - 01/2008)
6. Zanchetti, A: 2 articles (06/2015 - 06/2015)
7. Zhang, X: 2 articles (06/2015 - 06/2015)
8. Zhang, Y: 2 articles (06/2015 - 06/2015)
9. Liu, L: 2 articles (06/2015 - 06/2015)
10. Zhao, Feng: 2 articles (01/2012 - 08/2010)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Heart Failure
3. Angina Pectoris
4. Hyperemia
07/01/1993 - "Mucosal hyperemia and tachycardia, as an expression of the vasodilating properties of felodipine, were observed in a somewhat variable but dose-related manner. "
05/01/1996 - "During 30 minutes of reperfusion, felodipine had a beneficial effect upon coronary blood flow (initial postischemic hyperemia 245 +/- 38% of baseline in the felodipine group vs. 124 +/- 18% in the controls; p < 0.01) Felodipine markedly improved the recovery of contractile function [LV developed pressure recovered from a baseline of 104 +/- 4 to 75 +/- 6 mmHg (72%) in the felodipine group vs. 34 +/- 10 mmHg (32%) in the control group; p < 0.01], as well as diastolic function (LVEDP = 25 +/- 4 mmHg in the felodipine group vs. 61 +/- 10 mmHg in the controls; p < 0.05), and ATP levels (8.5 +/- 1.4 mumoles/g d.w. "
01/20/2006 - "FBF during reactive hyperemia was significantly improved by candesartan in patients without HRT (hyperemic peak flow and area under the FBF curve), whereas felodipine and placebo exerted no effect. "
07/01/2002 - "FBF during reactive hyperemia was significantly improved by candesartan, whereas felodipine and placebo exerted no effect. "
07/01/2011 - "We examined the effects of ARB administration on hyperinsulinemia-associated capillary density by measuring baseline skin capillary density, capillary density during reactive hyperemia (hyperemic capillary recruitment), and capillary density during venous congestion in 17 hypertensive individuals in the basal state, during a hyperinsulinemic euglycemic clamp, and during a hyperinsulinemic clamp with acute ARB administration (600 mg irbesartan), acute calcium channel blockade (CCB; 10mg felodipine ER), as a control for the reduction in blood pressure, or placebo. "
5. Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
11/01/2001 - "To compare the effects of active treatment compared with placebo on blood pressure, left ventricular hypertrophy, and quality of life among older stage 1 isolated systolic hypertensive patients, a randomized, double-blind, parallel-group, multicenter clinical trial comparing felodipine (2.5, 5, or 10 mg once daily) and matching placebo was performed in 171 patients (49% male, average age 66+/-7 years, with 49% white and 30% Hispanic) with a baseline blood pressure of 149+/-7/83+/-6 mm Hg. During 52 weeks of treatment, patients randomized to active treatment achieved significantly lower blood pressures (137.0+/-11.7/80.2+/-7.6 mm Hg for extended-release felodipine versus 147.5+/-16.0/83.5+/-9.7 mm Hg for placebo, P<0.01 for each), a reduced incidence of left ventricular hypertrophy (7% for extended release felodipine versus 24% for placebo, P<0.04), and improved quality of life (change in Psychological General Well-Being index, 3.0+/-6.8 for extended-release felodipine versus -0.8+/-10.3 for placebo, P<0.01) versus baseline. "
11/01/1994 - "Clinical studies show that antihypertensive treatment with felodipine promotes regression of left ventricular hypertrophy, increases compliance of large arteries, and has favourable effects on renal function. "
08/01/1992 - "In addition to its antihypertensive action, results suggest that felodipine therapy is associated with significant regression of left ventricular hypertrophy. "
03/01/1992 - "Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy."
09/01/1996 - "The efficacy of felodipine ER on regression of left ventricular hypertrophy in patients with primary hypertension."

Related Drugs and Biologics

1. Calcium
2. Metoprolol (Lopressor)
3. Amlodipine (Norvasc)
4. 1,4-dihydropyridine (dihydropyridine)
5. Verapamil (Calan)
6. Nifedipine (Adalat)
7. Diltiazem (Cardizem)
8. Nitrendipine
9. Calcium Channel Blockers (Blockers, Calcium Channel)
10. Enalapril

Related Therapies and Procedures

1. Oral Administration
2. Ligation
3. Transplantation (Transplant Recipients)
4. Surgical Instruments (Clip)
5. Radiotherapy