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Felodipine (Agon)

A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
Also Known As:
Agon; Felo Biochemie; Felo-Puren; Felobeta; Felocor; Felodipin 1A Pharma; Felodipin AL; Felodipin AZU; Felodipin AbZ; Felodipin Dura; Felodipin Heumann; Felodipin Stada; Felodipin Von Ct; Felodipin-Ratiopharm; Felodur; Felogamma; Fensel; Flodil; H 154-82; Modip; Munobal; Perfudal; Plendil; Renedil; Felo Puren; Felodipin Ratiopharm; H 154 82; H 15482; Heumann, Felodipin; Von Ct, Felodipin; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
Networked: 567 relevant articles (65 outcomes, 154 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Zhang, Wei: 3 articles (04/2020 - 07/2008)
2. FEVER Study Group: 3 articles (06/2011 - 12/2005)
3. Liu, Lisheng: 3 articles (06/2011 - 12/2005)
4. Zanchetti, Alberto: 3 articles (06/2011 - 12/2005)
5. Zhang, Xuezhong: 3 articles (06/2011 - 12/2005)
6. Zhang, Yun: 3 articles (09/2008 - 01/2008)
7. Qu, Xinhua: 2 articles (08/2022 - 01/2020)
8. Tang, Haozheng: 2 articles (08/2022 - 01/2020)
9. Yue, Bing: 2 articles (08/2022 - 01/2020)
10. Zhang, Shutao: 2 articles (08/2022 - 01/2020)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Essential Hypertension
3. Heart Failure
4. Stable Angina
5. Hyperemia
07/01/1993 - "Mucosal hyperemia and tachycardia, as an expression of the vasodilating properties of felodipine, were observed in a somewhat variable but dose-related manner. "
05/01/1996 - "During 30 minutes of reperfusion, felodipine had a beneficial effect upon coronary blood flow (initial postischemic hyperemia 245 +/- 38% of baseline in the felodipine group vs. 124 +/- 18% in the controls; p < 0.01) Felodipine markedly improved the recovery of contractile function [LV developed pressure recovered from a baseline of 104 +/- 4 to 75 +/- 6 mmHg (72%) in the felodipine group vs. 34 +/- 10 mmHg (32%) in the control group; p < 0.01], as well as diastolic function (LVEDP = 25 +/- 4 mmHg in the felodipine group vs. 61 +/- 10 mmHg in the controls; p < 0.05), and ATP levels (8.5 +/- 1.4 mumoles/g d.w. "
01/20/2006 - "FBF during reactive hyperemia was significantly improved by candesartan in patients without HRT (hyperemic peak flow and area under the FBF curve), whereas felodipine and placebo exerted no effect. "
07/01/2002 - "FBF during reactive hyperemia was significantly improved by candesartan, whereas felodipine and placebo exerted no effect. "
07/01/2011 - "We examined the effects of ARB administration on hyperinsulinemia-associated capillary density by measuring baseline skin capillary density, capillary density during reactive hyperemia (hyperemic capillary recruitment), and capillary density during venous congestion in 17 hypertensive individuals in the basal state, during a hyperinsulinemic euglycemic clamp, and during a hyperinsulinemic clamp with acute ARB administration (600 mg irbesartan), acute calcium channel blockade (CCB; 10mg felodipine ER), as a control for the reduction in blood pressure, or placebo. "

Related Drugs and Biologics

1. Calcium
2. Antihypertensive Agents (Antihypertensives)
3. Metoprolol (Toprol-XL)
4. Amlodipine (Norvasc)
5. 1,4-dihydropyridine (dihydropyridine)
6. Calcium Channel Blockers (Blockers, Calcium Channel)
7. Enalapril
8. Verapamil (Calan)
9. Nifedipine (Adalat)
10. Vasodilator Agents (Vasodilators)

Related Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Oral Administration
4. Ligation
5. Surgical Instruments (Clip)