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5'-Nucleotidase (5' Nucleotidase)

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A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.

Also Known As:

5' Nucleotidase; 5'-Nucleotidase Phosphoribolase; Antigen, CD73; IMPase; 5' AMP Nucleotidase; 5' Nucleotidase Phosphoribolase; CD73 Antigen; Ecto 5' Nucleotidase; Pyrimidine 5' Nucleotidase; Uridylate 5' Nucleotidase; 5'-AMP Nucleotidase; AMP Phosphatase; Adenylate Phosphatase; Antigens, CD73; CD73 Antigens; Cytidylate Phosphatase; Ecto-5'-Nucleotidase; IMP Nucleotidase; IMP Phosphatase; Inosinate Phosphatase; Pyrimidine 5'-Nucleotidase; Thymidine Phosphatase; Uridylate 5'-Nucleotidase; 5'-Ribonucleotide phosphohydrolase

Networked: 722 relevant articles (10 outcomes, 49 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Thompson, Linda F: 9 articles (05/2012 - 10/2002)
2.	Eltzschig, Holger K: 9 articles (04/2011 - 10/2002)
3.	Battastini, Ana Maria Oliveira: 8 articles (09/2014 - 06/2003)
4.	Bonan, Carla Denise: 6 articles (04/2015 - 06/2003)
5.	Braganhol, Elizandra: 6 articles (09/2014 - 08/2003)
6.	Bruno, Alessandra Nejar: 6 articles (04/2014 - 06/2003)
7.	Wink, Márcia R: 6 articles (04/2014 - 02/2007)
8.	Zhou, Ping: 6 articles (06/2013 - 01/2007)
9.	Zhi, Xiuling: 6 articles (06/2013 - 01/2007)
10.	Morsch, Vera Maria: 6 articles (02/2012 - 02/2003)

Related Diseases

1.	Ischemia 11/01/2008 - "Use of soluble 5'-nucleotidase may be a potential therapeutic for hepatic ischemia." 01/01/1992 - "Therefore 5'-nucleotidase inhibitors were administered to isolated, perfused adult rabbit hearts subjected to 120 minutes of ischemia (at 34 degrees C) to determine if this improved functional recovery. " 10/01/1998 - "This study tested the hypothesis that cardiac ecto-5'-nucleotidase (ecto-5'-NT) activity during ischemic preconditioning (PC) contributes to augmented tolerance against ischemia, thereby reducing infarct size in the rabbit heart in situ. " 02/01/1992 - "The purposes of this study were (1) to document 5'-nucleotidase activities in neonatal and adult rabbit myocardium and (2) to correlate differences of 5'-nucleotidase activity with functional recovery from ischemia. " 11/01/2008 - "Reconstitution of cd73(-/-) mice with soluble 5'-nucleotidase resulted in complete restoration of hepatoprotection by IP, and hepatic injury following ischemia was attenuated by treatment of WT mice with soluble 5'-nucleotidase. "
2.	Neoplasms (Cancer) 06/01/1981 - "A significant reduction of the activity of 5'-nucleotidase was observed in tumor homogenates compared with homogenates from normal ovaries. " 12/24/2015 - "We used a combined approach based on fragment-based drug design (FBDD) and in silico methods to design potential inhibitors of the cytosolic 5'-nucleotidase II (cN-II), which has been recognized as an important therapeutic target in hematological cancers. " 07/01/2015 - "Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models." 09/01/2014 - "In this work, we investigated the NTPDase3 and ecto-5'-nucleotidase/CD73 expression in cancer progression in vivo. " 09/01/2014 - "The ectonucleotidases, mainly ecto-5'-nucleotidase/CD73 have been revealed as new players in cancer progression and malignity. "
3.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 05/01/1990 - "5' Nucleotidase in chronic B cell leukemias: a cytochemical and ultrastructural study." 03/01/2002 - "Literature on the behaviour of ecto-5'-nucleotidase in the course of B-cell chronic lymphocytic leukemia is briefly reviewed and aims for further researches are highlighted." 03/01/2002 - "Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia." 06/01/1998 - "The activity of membrane-bound ecto-5'-nucleotidase and soluble e-Ns and c-N-II 5'-nucleotidases was evaluated on lymphocytes from patients affected by B-cell chronic lymphocytic leukemia (B-CLL). " 06/01/1998 - "5'-nucleotidase activity in lymphocytes from patients affected by B-cell chronic lymphocytic leukemia."
4.	Bipolar Disorder (Mania) 05/01/2010 - "In favor of this idea, IMPA2 encoding IMPase is a candidate susceptibility gene for bipolar disorder and that the risk-conferring single nucleotide polymorphisms enhance the promoter activity of IMPA2. " 04/01/2007 - "IMPA2, one of the genes that encode IMPase, is located in a region with linkage to bipolar disorder. " 04/11/2014 - "The enzymatic activity of IMPase is inhibited by lithium, a drug used for the treatment of mood swings seen in bipolar disorder. " 10/01/2012 - "Lithium, which is the drug of choice for bipolar disorder, inhibits IMPase at therapeutically relevant plasma concentrations. " 03/28/2012 - "According to the inositol depletion hypothesis, IMPase activity is assumed to be higher than normal in patients suffering from bipolar disorder. "
5.	Erectile Dysfunction 09/01/2005 - "The authors review epidemiology, classification, etiology and pathogenesis of erectile dysfunction (ED), its diagnosis and treatment with a focus on mechanisms of action and efficacy of the drug impase. " 11/01/2011 - "The results of the treatment showed that impase addition to combined treatment of CAP patients with erectile dysfunction significantly improves erectile function: 80.6% patients given impase raised their score by International Index of Erectile Function Scale to normal (26 points and higher). " 09/01/2005 - "[Impase in the treatment of erectile dysfunction]." 03/01/2004 - "[Use of impase in the therapy of erectile dysfunction]." 05/01/2003 - "Clinical efficacy and safety of the drug impase in erectile dysfunction (ED) were studied in 30 patients with ED of various genesis (mean age 52.09 +/- 4.75 years). "

Related Drugs and Biologics

1.	Adenosine
2.	Alkaline Phosphatase
3.	Adenine Nucleotides
4.	Venoms
5.	myo-inositol-1 (or 4)-monophosphatase (inositol monophosphatase)
6.	Deoxycytidine Kinase
7.	Alanine Transaminase (SGPT)
8.	Bilirubin
9.	Phosphatidylinositols (Phosphatidylinositol)
10.	Aspartic Acid (Aspartate)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Transplants (Transplant)
3.	Splenectomy
4.	Axotomy
5.	Homologous Transplantation (Allograft)