tat Gene Products (tat Protein)

Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.

Also Known As:

Networked: 245 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ensoli, Barbara: 12 articles (01/2015 - 04/2002)
2.	Cafaro, Aurelio: 6 articles (01/2015 - 09/2004)
3.	Caputo, Antonella: 6 articles (01/2015 - 09/2004)
4.	Ensoli, B: 6 articles (10/2001 - 01/2000)
5.	Gavioli, Riccardo: 5 articles (01/2015 - 10/2004)
6.	Bellino, Stefania: 5 articles (08/2011 - 01/2009)
7.	Nath, Avindra: 5 articles (10/2009 - 09/2003)
8.	Li, Jing: 4 articles (01/2014 - 04/2006)
9.	Tripiciano, Antonella: 4 articles (12/2009 - 09/2004)
10.	Caputo, A: 4 articles (01/2004 - 08/2000)

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS) 05/01/2003 - "A number of studies have documented the neurotoxic property of Tat protein, and Tat has therefore been proposed to contribute to AIDS-associated neurological diseases. " 01/01/2015 - "So far, Tat protein and the cellular pathways targeted by Tat may represent potential targets for new anti-HIV therapeutic approaches and vaccine development against AIDS. " 09/02/2014 - "The transacting activator of transduction (TAT) protein plays a key role in the progression of AIDS. " 01/01/2012 - "HIV-1 Tat protein has been shown to play multiple roles in the pathogenesis of AIDS; however, there is no information currently available on its effects on adipose tissue alterations. " 08/01/2011 - "Communication, recruitment and enrolment in the preventative and therapeutic phase I clinical trial against HIV/AIDS based on the recombinant HIV-1 Tat protein."
2.	Infection 08/01/2014 - "The expression of HERV-K (HML-2) is tightly regulated but becomes markedly increased following infection with HIV-1, in part due to the HIV-1 Tat protein. " 09/24/2013 - "The intermediate structure induced by Tat-interaction with Env could potentially provide an explanation for increased virus infection in the presence of Tat protein. " 09/01/2013 - "Infection with HIV-1 or stimulation with the HIV-1 Tat protein leads to the activation of K111 proviruses. " 03/01/2013 - "A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells." 02/01/2013 - "Further investigations revealed that direct HIV-1 infection or culture with HIV-1-derived Tat protein significantly enhanced human MDSC generation in vitro, and MDSCs from healthy donors could be directly infected by HIV-1 to facilitate HIV-1 replication and transmission, indicating that a positive-feedback loop between HIV-1 infection and MDSC expansion existed. "
3.	Inflammation 10/15/2003 - "By contrast, TAT-green fluorescent protein or dnRas lacking the TAT protein transduction domain did not block airway inflammation, cytokine production, or airway hyperresponsiveness. " 03/15/2008 - "Topical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice." 06/01/1998 - "Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement."
4.	Human Influenza (Influenza) 07/19/2013 - "The engineered MyoD (MyoD-IT) was designed to contain the TAT protein transduction domain for cell penetration and the membrane-disrupting INF7 peptide, which is an improved version of the HA2 peptide derived from influenza. "
5.	Kaposi Sarcoma (Kaposi's Sarcoma) 01/01/2003 - "In this study, serum samples from 18 patients with Kaposi's sarcoma from Tanzania, mostly males (n = 15 vs 3), were subjected to analysis with respect to HHV8-DNA load and antibody spectrum against the HIV-1 tat protein. " 10/01/2001 - "Previous studies indicated that the Tat protein of human immunodeficiency virus type-1 (HIV-1) is a progression factor for Kaposi's sarcoma (KS). " 10/01/2007 - "The epidemic Kaposi's sarcoma is strongly associated with HIV's detrimental effect on immune system and HIV's Tat protein proangiogenic properties. " 01/01/2003 - "In view of these observations and the published data, we suggest that cross-signalling pathways between the tat protein and HHV8-DNA are involved in the complexity of pathogenesis of Kaposi's sarcoma." 07/01/2001 - "HIV type 1 Tat protein is a survival factor for Kaposi's sarcoma and endothelial cells."

Related Drugs and Biologics

1.	Vaccines
2.	Cytokines
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Superoxide Dismutase
5.	INF7 peptide
6.	Trans-Activators (Trans-Acting Factor)
7.	RNA (Ribonucleic Acid)
8.	Antibodies
9.	Peptides
10.	Cyclin-Dependent Kinase Inhibitor p21

Related Therapies and Procedures

1.	Quantum Dots (Quantum Dot)
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Intraventricular Injections