rev Gene Products (rev Protein)

Trans-acting nuclear proteins whose functional expression are required for retroviral replication. Specifically, the rev gene products are required for processing and translation of the gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (CAR) in env, also known as the rev-responsive element (RRE), is responsive to the rev gene product. Rev is short for regulator of virion.

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Networked: 32 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Loyter, Abraham: 2 articles (06/2010 - 03/2003)
2.	Kamath, B Venkatesh: 1 article (10/2021)
3.	Mudgal, Jayesh: 1 article (10/2021)
4.	Pai, K Sreedhara Ranganath: 1 article (10/2021)
5.	Pai, Sahana: 1 article (10/2021)
6.	Castello, Alfredo: 1 article (12/2020)
7.	Davis, Ilan: 1 article (12/2020)
8.	Järvelin, Aino: 1 article (12/2020)
9.	Truman, Catherine Toni-Sue: 1 article (12/2020)
10.	Anastos, Kathryn: 1 article (01/2019)

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS) 03/11/2003 - "The HIV-1 Rev protein plays a pivotal role in viral replication, and therefore, inhibition of its function should block the progression of the virus-induced immune deficiency syndrome (AIDS). " 06/20/1996 - "Gene therapy for AIDS using retroviral mediated gene transfer to deliver HIV-1 antisense TAR and transdominant Rev protein genes to syngeneic lymphocytes in HIV-1 infected identical twins." 03/01/1995 - "Applications of transdominant mutants of human immunodeficiency virus type 1 (HIV-1) regulatory proteins, especially Rev mutant, have been attempted for gene therapy against AIDS, because the Rev protein is essential for viral replication. " 10/01/1992 - "The inhibition of HIV infection in cells stably expressing a transdominant Rev protein, in the absence of any deleterious effect on T cell function, suggests that such a strategy could provide a therapeutic effect in the T lymphocytes of acquired immunodeficiency syndrome patients." 10/01/1994 - "One such viral-specific protein is REV, and a monoclonal antibody (mAb) against the REV protein is a potential therapeutic for acquired immune deficiency syndrome (AIDS). "
2.	HIV Infections (HIV Infection) 10/01/1992 - "To determine whether such transdominant Rev proteins could provide long-term protection against HIV infection without affecting T cell function, T leukemia cell lines were stably transduced with a retroviral vector encoding a transdominant mutant of the Rev protein, M10. " 10/01/1992 - "The inhibition of HIV infection in cells stably expressing a transdominant Rev protein, in the absence of any deleterious effect on T cell function, suggests that such a strategy could provide a therapeutic effect in the T lymphocytes of acquired immunodeficiency syndrome patients." 02/01/1996 - "Niruriside showed specific inhibitory activity against the binding of REV protein to RRE RNA with an IC50 value of 3.3 microM; however, niruriside did not protect CEM-SS cells from acute HIV infection at concentrations up to 260 microM using an XTT dye reduction assay."
3.	Leukemia 10/01/1992 - "To determine whether such transdominant Rev proteins could provide long-term protection against HIV infection without affecting T cell function, T leukemia cell lines were stably transduced with a retroviral vector encoding a transdominant mutant of the Rev protein, M10. "
4.	Wilms Tumor (Wilm's Tumor) 01/01/1993 - "This method has proven useful in studies in which synthetic genes were constructed for the HIV-2 Rev protein (3,5) and the Wilms' tumor locus zinc finger protein (6). "
5.	Infections 10/01/2021 - "An insight on promising strategies hoping to cure HIV-1 infection by targeting Rev protein-short review." 02/01/1996 - "Differential degradation of Rev in the nucleus and cytoplasm may play a critical role in determining and maintaining different stages of human immunodeficiency virus type 1 infection, in conjunction with the shuttling properties of the Rev protein." 11/01/1995 - "The HIV-1 rev gene product facilitates the transport of singly spliced and unspliced HIV-1 transcripts and is necessary for productive HIV-1 infection. " 09/01/1992 - "Thus, FIV is dependent on a fully functional Rev protein and an RRE for productive infection." 12/01/2020 - "During late infection, HIV-1 bypasses this regulatory mechanism by expression of the Rev protein from a fully spliced mRNA. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Monoclonal Antibodies
3.	rex Gene Products
4.	RNA (Ribonucleic Acid)
5.	Antigens
6.	rev Gene Products (rev Protein)
7.	Nuclear Export Signals (Nuclear Export Signal)
8.	Therapeutic Uses
9.	Nuclear Pore Complex Proteins (Nucleoporins)
10.	gag Gene Products (gag Protein)