nef Gene Products (nef Gene Product)

Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.

Also Known As:

Networked: 125 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fackler, Oliver T: 8 articles (12/2015 - 04/2002)
2.	Kirchhoff, Frank: 6 articles (01/2018 - 07/2004)
3.	Geyer, Matthias: 5 articles (03/2014 - 02/2006)
4.	Saksela, Kalle: 5 articles (03/2014 - 07/2004)
5.	Olivetta, Eleonora: 4 articles (01/2014 - 12/2000)
6.	Sanchez, Massimo: 3 articles (01/2014 - 09/2005)
7.	Huang, Ming-Bo: 3 articles (06/2013 - 03/2004)
8.	Schindler, Michael: 3 articles (03/2011 - 07/2004)
9.	Federico, Maurizio: 3 articles (04/2009 - 12/2000)
10.	Giordani, Luciana: 3 articles (03/2009 - 05/2002)

Related Diseases

1.	Infections 01/01/2020 - "Importantly, we also identified a number of NeuN-positive neurons, which are not permissive to SIV infection, but contained Nef protein. " 08/01/2019 - "Almost 80% of viral transcripts during early HIV-1 infection encode the Nef protein, which has been implicated in altering expression of a number of genes. " 01/01/2017 - "Here, we elucidated the mechanism underlying apoptosis in Human Immunodeficiency Virus-1 (HIV-1) infection by examining host apoptotic pathways hijacked by the HIV-1 Nef protein in the CD4+ T-cell line Sup-T1. " 07/01/2016 - "It is believed that, the massive activation of CD4+ T cells (selectively with Vβ-12+, Vβ-5.3+ and Vβ-18+ TCRs) in early stages of infection and clonal deletion, anergy and apoptosis of bystander T cells in the late stages may be due to SAg property of Nef protein, as well as the other mechanisms. " 05/01/2012 - "The role of the multifunctional accessory Nef protein in the immunopathogenesis of HIV-2 infection is currently poorly understood. "
2.	Acquired Immunodeficiency Syndrome (AIDS) 06/23/2023 - "Exosomal extracellular vesicles (xEVs) in plasma and cerebrospinal fluid (CSF) of aviremic people living with HIV/AIDS (PLWHA) contain the HIV Negative factor (Nef) protein. " 03/01/2017 - "Therefore, targeting Nef protein is considered as a key strategy towards HIV/AIDS treatment. " 03/01/2017 - "Human immunodeficiency virus (HIV)-negative factor (Nef) protein is an accessory pathogenic factor, which plays a significant role in acquired immune deficiency syndrome (AIDS). " 11/01/2016 - "IMPORTANCE The HIV-1 Nef protein has been established as a key pathogenic determinant of HIV/AIDS, but there is little knowledge of how the extensive genetic diversity of HIV-1 affects Nef function. " 01/01/2016 - "Interestingly, trans-cellular introduction of recombinant Nef protein in Caenorhabditis elegans results in AIDS like pathogenesis which might share common pathophysiology because the gene sequence of C. elegans and humans share considerable homology. "
3.	AIDS Dementia Complex 03/01/1994 - "In previous studies, using polymerase chain reaction amplification of HIV-1 genes directly from pathologic tissues of children who died with AIDS encephalopathy, we showed that the reading frame of the HIV-1 regulatory nef gene is open, suggesting that the nef protein was expressed. " 06/01/1998 - "We conclude from this that expression of Nef within the CNS is such that little or no antibody production occurs and that these differences indicate that Nef protein may not be directly contributing to the AIDS dementia complex. "
4.	Lymphoma (Lymphomas) 07/01/1998 - "The studies reported here show that viral induction of T-cell proliferation requires accessory cells, such as primary monocytes or Raji B-lymphoma cells, as well as the presence of a putative immunoreceptor tyrosine-based activation motif within the viral Nef protein. "
5.	Hyperglycemia 10/30/2009 - "Interestingly, the delivery of HIV-1 Nef protein alone caused similar damage to CNS as augmented by hyperglycemia conditions. " 10/30/2009 - "To further verify the effects of hyperglycemia and HIV-1 Nef protein on CNS individually or in combination, in vivo studies were performed in streptozotocin (STZ) induced diabetic mice, by injecting HIV-1 Nef expressing viral particles into the sub-cortical region of the brain. " 10/30/2009 - "The expression of Nef protein delivered via HIV-1 vectors in combination with hyperglycemia further augmented the production of ROS, C3, activation of caspase-3, modulation of filamentous protein (F-protein), depolarization of the mitochondria, and loss of astrocytes. "

Related Drugs and Biologics

1.	Antibodies
2.	Streptozocin (Streptozotocin)
3.	Proteins (Proteins, Gene)
4.	Peptides (Polypeptides)
5.	Virulence Factors (Pathogenicity Factors)
6.	T-Cell Antigen Receptors (T-Cell Receptor)
7.	Proline (L-Proline)
8.	Antiviral Agents (Antivirals)
9.	Antigens
10.	p21-Activated Kinases

Related Therapies and Procedures

1.	Therapeutics