nef Gene Products (nef Gene Product)

Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.

Also Known As:

Networked: 108 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fackler, Oliver T: 8 articles (01/2015 - 04/2002)
2.	Kirchhoff, Frank: 5 articles (01/2014 - 07/2004)
3.	Geyer, Matthias: 5 articles (01/2014 - 02/2006)
4.	Saksela, Kalle: 5 articles (01/2014 - 07/2004)
5.	Olivetta, Eleonora: 3 articles (01/2014 - 09/2005)
6.	Sanchez, Massimo: 3 articles (01/2014 - 09/2005)
7.	Schindler, Michael: 3 articles (01/2011 - 07/2004)
8.	Viora, Marina: 3 articles (03/2009 - 05/2002)
9.	Quaranta, Maria Giovanna: 3 articles (03/2009 - 05/2002)
10.	Giordani, Luciana: 3 articles (03/2009 - 05/2002)

Related Diseases

1.	Infection 05/01/2012 - "The role of the multifunctional accessory Nef protein in the immunopathogenesis of HIV-2 infection is currently poorly understood. " 10/01/2011 - "Because of the multi-functional nature of the Nef protein, it is unclear which of the several Nef activities are most crucial in vivo for the outcome of viral infection. " 03/01/2009 - "Here, we review the recent progress on the immunomodulatory effect of the accessory Nef protein and its role in the pathogenesis of HIV-1 infection. " 07/17/2008 - "Collectively, these results indicate that the HIV-1 Nef protein carries a pathogenic determinant that governs B cell defects in HIV-1 infection." 05/01/2007 - "The human immunodeficiency virus type 1 Nef protein performs several functions potentially important for successful infection, including immune escape via down-regulation of class I major histocompatibility complex (MHC-I) and direct enhancement of viral infectivity and replication. "
2.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/2015 - "The Nef protein of human immunodeficiency virus (HIV) promotes viral replication and progression to AIDS. " 01/01/2012 - "HIV-1 Nef protein contributes essentially to the pathology of AIDS by a variety of protein-protein-interactions within the host cell. " 03/31/2011 - "The Nef protein of HIV-1 is important for AIDS pathogenesis, but it is not targeted by current antiviral strategies. " 04/01/2009 - "The Nef protein of the human immunodeficiency virus type 1 (HIV-1) plays a crucial role in AIDS pathogenesis by modifying host cell signaling pathways. " 02/21/2006 - "The accessory HIV-1 Nef protein is essential for viral replication, high virus load, and progression to AIDS. "
3.	AIDS Dementia Complex 03/01/1994 - "In previous studies, using polymerase chain reaction amplification of HIV-1 genes directly from pathologic tissues of children who died with AIDS encephalopathy, we showed that the reading frame of the HIV-1 regulatory nef gene is open, suggesting that the nef protein was expressed. " 06/01/1998 - "We conclude from this that expression of Nef within the CNS is such that little or no antibody production occurs and that these differences indicate that Nef protein may not be directly contributing to the AIDS dementia complex. "
4.	Lymphoma (Lymphomas) 07/01/1998 - "The studies reported here show that viral induction of T-cell proliferation requires accessory cells, such as primary monocytes or Raji B-lymphoma cells, as well as the presence of a putative immunoreceptor tyrosine-based activation motif within the viral Nef protein. "
5.	Hyperglycemia 01/01/2009 - "Interestingly, the delivery of HIV-1 Nef protein alone caused similar damage to CNS as augmented by hyperglycemia conditions. " 01/01/2009 - "To further verify the effects of hyperglycemia and HIV-1 Nef protein on CNS individually or in combination, in vivo studies were performed in streptozotocin (STZ) induced diabetic mice, by injecting HIV-1 Nef expressing viral particles into the sub-cortical region of the brain. " 01/01/2009 - "The expression of Nef protein delivered via HIV-1 vectors in combination with hyperglycemia further augmented the production of ROS, C3, activation of caspase-3, modulation of filamentous protein (F-protein), depolarization of the mitochondria, and loss of astrocytes. "

Related Drugs and Biologics

1.	Antibodies
2.	Tyrosine (L-Tyrosine)
3.	Streptozocin (Streptozotocin)
4.	Proteins (Proteins, Gene)
5.	T-Cell Antigen Receptors (T-Cell Receptor)
6.	Carbon Monoxide
7.	Antigens
8.	p21-Activated Kinases
9.	Human Immunodeficiency Virus nef Gene Products
10.	Caspase 3 (Caspase-3)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)