env Gene Products

Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease.

Also Known As:

Networked: 168 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miller, A Dusty: 7 articles (08/2008 - 03/2002)
2.	Wang-Johanning, Feng: 6 articles (07/2015 - 01/2007)
3.	Plummer, Joshua B: 5 articles (07/2015 - 07/2008)
4.	Johanning, Gary L: 5 articles (01/2015 - 01/2007)
5.	Rycaj, Kiera: 5 articles (01/2015 - 01/2007)
6.	Perron, Hervé: 4 articles (01/2015 - 12/2008)
7.	Yin, Bingnan: 3 articles (01/2015 - 09/2011)
8.	Li, Ming: 3 articles (01/2015 - 09/2011)
9.	Barnett, Susan W: 3 articles (01/2015 - 06/2010)
10.	Montefiori, David C: 3 articles (09/2014 - 08/2011)

Related Diseases

1.	Infection 01/01/2009 - "Further studies with HIV-1 lacking the Env protein also resulted in infection of DC. " 05/15/2007 - "In the present study, we show that HIV-1 entry and infection of polarized trophoblasts are independent not only of CD4 but also of envelope (Env) glycoproteins gp120 and gp41. " 09/01/2015 - "The human immunodeficiency virus type 1 (HIV-1) 92UG046 Env protein, obtained from a CD4-independent HIV-1 primary isolate (Zerhouni et al., 2004), has the ability to initiate an infection in HeLa cells expressing CD4 when carrying the full-length (FL) Env, but uses CD8 molecules for receptor-mediated entry when carrying a truncated Env (CT84). " 01/02/2015 - "A peptide triazole (PT) class of entry inhibitor has previously been shown to bind to HIV-1 gp120, suppress interactions of the Env protein at host cell receptor binding sites, inhibit cell infection, and cause envelope spike protein breakdown, including gp120 shedding and, for some variants, virus membrane lysis. " 01/01/2015 - "In vitro HIV-1 dual infections were used to recombine subtypes A and D isolates and examine breakpoints in the Env glycoproteins. "
2.	HIV Infections (HIV Infection) 06/01/2010 - "These results highlight the merit of the alphavirus replicon vector prime plus Env protein boost vaccine approach for the induction of protective antibody responses and are of particular relevance to advancing our understanding of the potential correlates of immune protection against HIV infection at a relevant mucosal portal of entry." 11/01/2011 - "Analysis of the late steps of the HIV infection cycle shows that Rab7A regulates Env processing, the incorporation of mature Env glycoproteins into viral particles and HIV-1 infectivity. " 12/15/1993 - "At levels of env protein expression sufficient to mediate syncytium formation and to kill cells, these HIV-1 env transfectants displayed no intrinsic T cell signaling abnormalities, suggesting that mechanisms other than a direct intracellular action of the tat or env proteins may be contributing to the deficit in Ag-specific T cell activation described subsequent to HIV infection in vivo and in vitro." 02/01/2015 - "Because the lectins, Hippeastrum hybrid agglutinin (HHA) and Galanthus nivalis agglutinin (GNA), are potent inhibitors of HIV infection and bind the oligomannans on the HIV Env protein, we hypothesized that they would bind specifically to cells expressing the HIV Env protein on their plasma membrane. " 10/01/1992 - "Serum IgA subclasses and molecular forms in HIV infection: selective increases in monomer and apparent restriction of the antibody response to IgA1 antibodies mainly directed at env glycoproteins."
3.	T-Cell Leukemia (Leukemia, T Cell) 01/01/2003 - "Human T-cell leukemia virus (HTLV) envelope (Env) glycoproteins induce fusion, leading to rampant syncytium formation in a broad range of cell lines. " 11/01/2002 - "Functional domains of the strikingly conserved envelope (Env) glycoproteins of bovine leukemia virus (BLV) and its close relative, human T-cell leukemia virus type 1 (HTLV-1), are still being defined. " 07/01/1987 - "ML, a transplantable T-cell leukemia of DBA/2 mice, expresses the gag and env gene products of the murine mammary tumor virus (MuMTV). " 01/01/1987 - "Chemical-enzymatic synthesis, cloning and expression of a synthetic gene coding for an env protein fragment of the human T-cell leukemia virus type 1." 07/30/1984 - "Identification of gag and env gene products of human T-cell leukemia virus (HTLV)."
4.	HTLV-I Infections (HTLV-I Infection) 09/15/1987 - "Protection against human T-cell leukemia virus type-I (HTLV-I) infection in cynomolgus monkeys, achieved by immunizing the animals with env gene products of HTLV-I produced in Escherichia coli, was evaluated. "
5.	Contagious Ecthyma (Orf) 05/20/2004 - "In this study, we examined the processing of the Env protein as well as the maturation and infectivity of a virus (SHIV(Vpenv)) in which a single nucleotide was removed at the vpu-env junction, fusing the first 162 bases of vpu to the env ORF. " 07/01/1999 - "A third ORF encodes the remaining part of the ENV protein. " 01/01/1992 - "Expression of HIV-1 Env protein requires a weak vpu AUG, which allows leaky scanning to occur, thereby allowing ribosomes access to the downstream env ORF. " 07/01/2012 - "In the present study, we used the reverse immunology approach to test the immunological potential of this HERV-H ORF on Xp22.3. A total of ten peptides displaying HLA-A2.1-binding motifs were selected from the predicted env protein sequence. " 02/01/1992 - "Recombinant baculoviruses incorporating BIV env ORF sequences were constructed to characterize the expression, processing, and immunogenicity of products of the BIV env ORF in insect cells and to develop reagents to study native BIV Env glycoproteins. "

Related Drugs and Biologics

1.	Antibodies
2.	Antigens
3.	gag Gene Products (gag Protein)
4.	Peptides
5.	Glycoproteins (Glycoprotein)
6.	Protein Kinases (Protein Kinase)
7.	Ligands
8.	Indicators and Reagents (Reagents)
9.	Proteins (Proteins, Gene)
10.	Neutralizing Antibodies

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Ligation