Osteonectin

Non-collagenous, calcium-binding glycoprotein of developing bone. It links collagen to mineral in the bone matrix. In the synonym SPARC glycoprotein, the acronym stands for Secreted Protein, Acidic and Rich in Cysteine.

Also Known As:

Networked: 220 relevant articles (1 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Delany, Anne M: 5 articles (04/2015 - 04/2007)
2.	Kessler, Catherine B: 4 articles (04/2015 - 04/2007)
3.	Sage, E Helene: 4 articles (04/2011 - 09/2003)
4.	Park, So Yeon: 3 articles (09/2015 - 02/2010)
5.	Adwan, Hassan: 3 articles (07/2010 - 02/2004)
6.	Berger, Martin R: 3 articles (07/2010 - 02/2004)
7.	Jang, Min Hye: 2 articles (09/2015 - 11/2013)
8.	Kim, Hyun Jeong: 2 articles (09/2015 - 11/2013)
9.	Kim, Eun Joo: 2 articles (09/2015 - 11/2013)
10.	Kapinas, Kristina: 2 articles (04/2015 - 06/2012)

Related Diseases

1.	Necrosis 05/01/2009 - "It is now possible to identify factors clearly favoring the formation of VC: TNF-alpha (which stimulates cell necrosis/apoptosis), CRP, oxidized lipids, AGEs, leptin, inorganic phosphate, high calcium-phosphorus product (CaxPO(4)), calcium, 1,25-OH(2)D(3) and Vitamin D(3), PTHrP (via an intracrine pathway), cyclic AMP, TGF-beta, bone morphogenic protein 2 (BMP2) and factors protective against the formation of VC: magnesium, HDL, inorganic pyrophosphate, albumin, ahsg/fetuin A, osteopontin (OPN), osteoprotegerin (OPG), osteonectin (ON), bone morphogenic protein 7 (BMP7), klotho, PTHrP (via a paracrine pathway), matrix gla protein (MGP), PTH (via Msx2) and vitamin K. "
2.	Neoplasms (Cancer) 08/01/2005 - "In vitro studies showed that osteonectin was able to inhibit cancer cell growth while promoting invasiveness of pancreatic tumor cells. " 06/01/2012 - "However, the presence of osteonectin in cancer cells and the stroma may limit prostate tumor development and progression. " 01/01/2007 - "Although the importance of tumor-stroma interactions in periampullary cancers is not fully understood, our data suggest that osteonectin is an integral stromal element in ampullary cancers, and its overexpression is associated with decreased survival." 01/01/2007 - "Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer." 05/01/2006 - "Secreted protein acidic and rich in cystein (SPARC)/osteonectin is a multifunctional matricellular protein involved in cell-matrix interactions and might be involved in tumor pathogenesis and progression. "
3.	Osteosarcoma (Osteogenic Sarcoma) 01/01/1996 - "This study revealed that immunohistochemical localization of osteonectin is not useful in providing conclusive diagnosis of osteosarcoma. " 01/01/1996 - "Immunohistochemically, osteonectin was present in all the osteosarcomas in this study. " 04/01/1992 - "According to the results of the study, osteonectin was present in all osteosarcomas. " 10/01/1990 - "According to the results of our study, osteonectin is present in all osteosarcomas, with special topographic preponderance in the osteoblastic and chondroblastic variants. " 08/01/1988 - "Immunohistochemical study of osteonectin in various types of osteosarcoma."
4.	Breast Neoplasms (Breast Cancer) 02/01/2006 - "Although osteonectin increased undirected MDA-MB-231 cell motility, it did not chemoattract the same breast cancer cell line. " 02/01/2006 - "Bone-derived osteonectin was then analyzed to assess its influence on breast cancer cell motility and migration. " 02/01/2006 - "Roles of osteonectin in the migration of breast cancer cells into bone." 08/15/2005 - "Increased expression of osteonectin is found in malignant breast tumors. " 04/01/2005 - "Increased levels of SPARC (osteonectin) in human breast cancer tissues and its association with clinical outcomes."
5.	Cataract (Cataracts) 06/01/2012 - "[Expression of osteonectin in lens epithelium cells in age-related cataract]." 08/01/2000 - "Deletion of osteonectin/SPARC causes age-onset cataract in mice and the cataractous human lens has increased expression of osteonectin/SPARC. " 04/05/2000 - "The purpose of the present study was to evaluate the corresponding levels of osteonectin/SPARC protein in age-related cataractous relative to normal lenses and to evaluate the levels of osteonectin/SPARC transcript in specific types of age-related human cataracts. " 06/01/2012 - "To study the expression of osteonectin (also called secreted protein acidic and rich in cysteine, SPARC) in the lens epithelium cells in cortex cataract and nucleus cataract. " 09/17/1998 - "The present study provides evidence for up-regulation of osteonectin in human age-related cataract and suggests that osteonectin, a protein involved in cell-cycle control, extracellular matrix and Ca++ binding, plays an important role in human lens homeostasis and may be involved in processes leading to lens opacity."

Related Drugs and Biologics

1.	Osteopontin
2.	matrix Gla protein
3.	Calcium
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Leptin
6.	Osteoprotegerin
7.	Transforming Growth Factor beta (TGF-beta)
8.	Parathyroid Hormone-Related Protein
9.	Vitamin K
10.	Phosphorus

Related Therapies and Procedures

1.	Stents
2.	Myocardial Revascularization
3.	Lenses
4.	Heterologous Transplantation (Xenotransplantation)
5.	Drug Therapy (Chemotherapy)