Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)

A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)

Also Known As:

Myalgic Encephalomyelitis; Encephalomyelitis, Myalgic; Postviral Fatigue Syndrome; Fatigue Syndrome, Chronic; Chronic Fatigue Disorder; Chronic Fatigue and Immune Dysfunction Syndrome; Chronic Fatigue-Fibromyalgia Syndrome; Royal Free Disease; Systemic Exertion Intolerance Disease; Chronic Fatigue Disorders; Chronic Fatigue Fibromyalgia Syndrome; Chronic Fatigue Syndromes; Chronic Fatigue-Fibromyalgia Syndromes; Fatigue Disorder, Chronic; Fatigue Syndrome, Postviral; Fatigue Syndromes, Chronic; Fatigue-Fibromyalgia Syndrome, Chronic; Fatigue-Fibromyalgia Syndromes, Chronic; Infectious Mononucleosis Like Syndrome, Chronic; Postviral Fatigue Syndromes; Syndrome, Postviral Fatigue; Infectious Mononucleosis-Like Syndrome, Chronic

Networked: 1559 relevant articles (95 outcomes, 260 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)
2.	Fatigue
3.	Fibromyalgia (Fibrositis)
4.	Infections
5.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel)

Experts

1.	Maes, Michael: 42 articles (04/2022 - 10/2005)
2.	Chalder, Trudie: 23 articles (10/2022 - 02/2004)
3.	Nijs, Jo: 20 articles (11/2020 - 08/2004)
4.	Bleijenberg, Gijs: 19 articles (12/2020 - 01/2005)
5.	Knoop, Hans: 18 articles (01/2022 - 01/2007)
6.	Scheibenbogen, Carmen: 18 articles (01/2022 - 08/2015)
7.	Marshall-Gradisnik, Sonya: 16 articles (01/2022 - 01/2015)
8.	Staines, Donald: 16 articles (01/2022 - 01/2005)
9.	Vernon, Suzanne D: 14 articles (01/2022 - 01/2002)
10.	Klimas, Nancy G: 14 articles (01/2021 - 03/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Fatigue Syndrome:

1.	Antidepressive Agents (Antidepressants)IBA 01/01/1997 - "There is a strong association between the chronic fatigue syndrome and both depressive illness and sleep disturbance, but the efficacy of antidepressants is uncertain. " 02/01/2009 - "Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations." 09/14/2009 - "An experimental model of chronic fatigue syndrome (CFS) is utilized for evaluation of antidepressant, anti-stress effects, wherein the rat is forced to swim in water for 15 min/day on 21 consecutive days. " 07/01/2009 - "Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants." 12/01/2006 - "An investigation of the long-term benefits of antidepressant medication in the recovery of patients with chronic fatigue syndrome."
2.	MelatoninIBA 01/01/2006 - "The effect of melatonin, a chronobiotic drug, was explored in 29 patients with chronic fatigue syndrome (CFS) and Dim Light Melatonin onset (DLMO) later than 21.30 hours, reflective of delayed circadian rhythmicity. " 10/01/2000 - "High nocturnal melatonin in adolescents with chronic fatigue syndrome." 07/01/1996 - "Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome." 01/01/2006 - "Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion." 12/01/1999 - "Melatonin levels in women with fibromyalgia and chronic fatigue syndrome."
3.	Moclobemide (Arima)IBA 09/01/2000 - "Moclobemide produces some improvement in key symptoms experienced by patients with chronic fatigue syndrome. " 09/01/2000 - "A randomized, double-blind placebo-controlled trial of moclobemide in patients with chronic fatigue syndrome." 01/01/1997 - "An open study of the efficacy and adverse effects of moclobemide in patients with the chronic fatigue syndrome." 01/01/1995 - "Clinical trials are in progress on the effect of moclobemide in chronic fatigue syndrome. " 01/01/1997 - "We studied the efficacy and adverse effects of moclobemide in patients with chronic fatigue syndrome, stratifying the sample both by co-morbid major depressive illness and by sleep disturbance. "
4.	poly(I).poly(c12,U) (ampligen)IBA 01/01/2004 - "Previously, Hemispherx submitted an application to the EMEA for the approval of Ampligen for the treatment of chronic fatigue syndrome; the first stage of th;) for the treatment of chronic fatigue syndrome; the first stage of the regulatory review has been cleared. " 01/01/2004 - "Bioclones has initiated clinical studies with Ampligen for the treatment of chronic fatigue syndrome in Australia. " 01/01/2012 - "A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome." 01/01/2004 - "Ampligen is available for severe chronic fatigue syndrome on a named patient, cost-recovery basis in South Africa. " 01/01/2004 - "In the meantime, Ampligen has been available since May 1996 under the Canadian Emergency Drug Release Programme for the treatment of chronic fatigue syndrome and immune dysfunction syndrome by Rivex Pharma (Helix BioPharma). "
5.	Valacyclovir (Valtrex)FDA LinkGeneric 08/01/2002 - "A six-month trial of valacyclovir in the Epstein-Barr virus subset of chronic fatigue syndrome: improvement in left ventricular function." 09/01/2007 - "Valacyclovir treatment in Epstein-Barr virus subset chronic fatigue syndrome: thirty-six months follow-up." 04/01/2022 - "This study aimed to compare the efficacy of valaciclovir, valganciclovir, and artesunate in treating chronic reactivated human herpesvirus type 6 (HHV-6) and human herpesvirus type 7 (HHV-7) infection associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). " 04/01/2022 - "A comparative study of valaciclovir, valganciclovir, and artesunate efficacy in reactivated HHV-6 and HHV-7 infections associated with chronic fatigue syndrome/myalgic encephalomyelitis."
6.	AntibodiesIBA 04/01/2001 - "In addition, preliminary data suggest that the presence of antilamin antibodies may be helpful in the diagnosis of chronic fatigue syndrome. " 01/01/1993 - "Second, a series of studies have detailed elevations of antibodies to most herpesviruses in selected chronic fatigue syndrome populations, with Epstein-Barr virus and human herpes type 6 being the objects of most scrutiny. " 06/01/1997 - "Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome." 09/01/1994 - "Simultaneous measurement of antibodies to Epstein-Barr virus, human herpesvirus 6, herpes simplex virus types 1 and 2, and 14 enteroviruses in chronic fatigue syndrome: is there evidence of activation of a nonspecific polyclonal immune response?" 06/01/1992 - "Antibodies against Sarcocystis and Toxoplasma in humans with the chronic fatigue syndrome."
7.	Valganciclovir FDA Link 12/01/2013 - "Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome." 12/01/2012 - "Response to valganciclovir in chronic fatigue syndrome patients with human herpesvirus 6 and Epstein-Barr virus IgG antibody titers." 12/01/2012 - "Valganciclovir has been reported to improve physical and cognitive symptoms in patients with chronic fatigue syndrome (CFS) with elevated human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) IgG antibody titers. " 04/01/2022 - "This study aimed to compare the efficacy of valaciclovir, valganciclovir, and artesunate in treating chronic reactivated human herpesvirus type 6 (HHV-6) and human herpesvirus type 7 (HHV-7) infection associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). " 04/01/2022 - "A comparative study of valaciclovir, valganciclovir, and artesunate efficacy in reactivated HHV-6 and HHV-7 infections associated with chronic fatigue syndrome/myalgic encephalomyelitis."
8.	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 10/10/2011 - "Epigallocatechin gallate ameliorates behavioral and biochemical deficits in rat model of load-induced chronic fatigue syndrome." 12/28/2009 - "Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence." 12/28/2009 - "The present study points out towards the beneficial effect of epigallocatechin gallate in the amelioration of chronic fatigue syndrome and thus may provide a new, effective and powerful strategy to treat chronic fatigue syndrome." 06/01/2010 - "Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome."
9.	CalciumIBA 12/03/2019 - "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell cytotoxicity, a mechanism tightly regulated by calcium (Ca2+). " 01/01/2023 - "Altered TRPM7-Dependent Calcium Influx in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients." 04/28/2023 - "Many skeletal muscle diseases such as muscular dystrophy, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and sarcopenia share the dysregulation of calcium (Ca2+) as a key mechanism of disease at a cellular level. " 01/01/2022 - "Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients." 02/01/2017 - "Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels."
10.	Eicosapentaenoic AcidIBA 04/01/2004 - "The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome." 01/01/2010 - "Copy number variation, eicosapentaenoic acid and neurological disorders with particular reference to Huntington's disease and associated CAG repeats, and to myalgic encephalomyelitis and viral infection." 04/01/2004 - "These results, which are consistent with a recent detailed report of cerebral and clinical changes associated with a high intake of eicosapentaenoic acid, suggest that this n-3 highly unsaturated fatty acid may offer the hope of effective treatment for at least some patients with chronic fatigue syndrome." 03/01/2004 - "Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes." 04/01/2004 - "A series of patients with chronic fatigue syndrome were treated solely with a high-eicosapentaenoic acid-containing essential fatty acid supplement. "

Therapies and Procedures

1.	Therapeutics 05/01/2002 - "Review: cognitive behavioural therapy and graded exercise show the most promise for chronic fatigue syndrome." 12/19/2019 - "The FITNET-NHS Trial is a UK, national, trial investigating whether an online cognitive behavioural therapy program (FITNET-NHS) for treating chronic fatigue syndrome/ME in adolescents is clinically effective and cost-effective in the NHS. " 01/01/2020 - "Cognitive-behavioural therapy (CBT) is effective in chronic fatigue syndrome. " 05/01/2014 - "FMT therapy could also be effective in treatment of some nongastrointestinal disorders such as chronic fatigue syndrome. " 12/01/2012 - "Internet-based cognitive behavioural therapy (FITNET) is an effective treatment for adolescents with chronic fatigue syndrome."
2.	Exercise Therapy (Therapy, Exercise) 08/01/2021 - "Graded exercise therapy (GET) is an effective treatment for chronic fatigue syndrome (CFS), but concerns have been raised about its safety. " 01/01/2017 - "Graded exercise therapy is an effective and safe treatment for chronic fatigue syndrome, but it is therapist intensive and availability is limited. " 03/01/2005 - "The aim of this study was to investigate the potential mechanisms underlying the efficacy of graded exercise therapy for chronic fatigue syndrome (CFS). " 10/01/2022 - "Graded exercise therapy for patients with chronic fatigue syndrome in secondary care - a benchmarking study." 10/01/2022 - "This systematic review investigated randomized controlled trials evaluating cognitive behavioral therapy (CBT) and graded exercise therapy (GET) for adults with chronic fatigue syndrome (CFS). "
3.	Moxibustion 10/01/2023 - "To observe the efficacy of moxibustion in the treatment of chronic fatigue syndrome (CFS) and explore the effects on gut microbiota and metabolic profiles. " 05/07/2021 - "This study will objectively and comprehensively evaluate the efficacy and safety of randomized controlled trials of moxibustion in the treatment of chronic fatigue syndrome, and the results will be submitted to peer-reviewed journals for publication. " 04/01/2016 - "In the present study, we aimed to determine the effect of moxibustion on behavioral symptoms in chronic fatigue syndrome rats and examine possible mechanisms. " 08/01/2014 - "[Randomized controlled clinical trials of acupuncture and moxibustion treatment of chronic fatigue syndrome patients]." 01/01/2008 - "Studies on the treatment of chronic fatigue syndrome (CFS) with acupuncture and moxibustion in China were reviewed. "
4.	Aftercare (After-Treatment) 08/01/2013 - "Letter to the editor: 'Recovery from chronic fatigue syndrome after treatments given in the PACE trial': recovery or remission?" 10/01/2013 - "Recovery from chronic fatigue syndrome after treatments given in the PACE trial." 08/01/2013 - "Letter to the editor: response to correspondence concerning 'recovery from chronic fatigue syndrome after treatments in the PACE trial'." 08/01/2013 - "Letter to the editor: comments on 'Recovery from chronic fatigue syndrome after treatments given in the PACE trial'." 08/01/2013 - "Letter to the editor: comments on 'Recovery from chronic fatigue syndrome after treatments given in the PACE trial'."
5.	Acupuncture Therapy 11/25/2021 - "Acupuncture therapy is effective in the treatment of chronic fatigue syndrome (CFS) and has its own unique advantages. " 07/01/2010 - "[Randomized controlled study on acupuncture treatment for chronic fatigue syndrome]." 12/01/2009 - "[A meta analysis on randomized controlled trials of acupuncture treatment of chronic fatigue syndrome]." 04/01/2009 - "[Randomized controlled clinical trials of acupuncture treatment of chronic fatigue syndrome]." 07/25/2023 - "From the databases, such as CNKI, VIP, Wanfang, SinoMed, PubMed, Web of Science, Embase and Cochrane Library, the literature of animal experiment on acupuncture treatment for chronic fatigue syndrome was searched from January 1st, 2011 to April 2nd, 2022. "