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Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)

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This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.

Also Known As:

Co-Trimoxazole; Lescot; Bactrim; Centran; Septra; Septrin; Trimethoprim-Sulfamethoxazole; Abactrim; Bactifor; Biseptol; Biseptol-480; Centrin; Cotrimoxazole; Drylin; Eslectin; Eusaprim; Insozalin; Kepinol; Kepinol Forte; Metomide; Oriprim; Sulfamethoxazole-Trimethoprim Combination; Sulprim; Sumetrolim; TMP SMX; TMP-SMX; Trimedin; Trimethoprimsulfa; Trimezole; Trimosulfa; Biseptol 480; Biseptol480; Co Trimoxazole; Sulfamethoxazole Trimethoprim Combination; Trimethoprim Sulfamethoxazole; Trimethoprim Sulfamethoxazole Combination; Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine

Networked: 3778 relevant articles (426 outcomes, 438 trials/studies)

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Drug Context: Research Results

Experts

1.	Mermin, Jonathan: 12 articles (04/2012 - 10/2004)
2.	Raoult, Didier: 11 articles (01/2015 - 03/2002)
3.	Dorsey, Grant: 10 articles (12/2014 - 09/2006)
4.	Walker, A Sarah: 9 articles (03/2015 - 01/2007)
5.	Kamya, Moses R: 9 articles (12/2014 - 10/2007)
6.	Anglaret, Xavier: 8 articles (04/2015 - 01/2005)
7.	Juurlink, David N: 8 articles (03/2015 - 04/2003)
8.	Gibb, Diana M: 8 articles (03/2015 - 01/2007)
9.	Gupta, Kalpana: 8 articles (10/2014 - 07/2002)
10.	Tappero, Jordan W: 7 articles (12/2014 - 10/2010)

Related Diseases

1.	Infection 01/01/1998 - "Modern treatment options, including prophylaxis with trimethoprim-sulfamethoxazole and rIFN-gamma as well as early and aggressive anti-infection therapy, have improved the prognosis of this disease dramatically. " 01/01/2003 - "The infection was treated successfully with trimethoprim-sulfamethoxazole. " 01/01/1998 - "Cyclospora infections can be treated successfully with trimethoprim-sulfamethoxazole." 02/01/1989 - "The exclusive use of TMP/SMX produced a significant reduction in mortality (P less than 0.0001) and an absence of clinical signs of infection. " 05/01/1982 - "These data indicated that a mean dose of TMP/SMX 6.8/34 mg/kg/d divided into twice daily doses and given for six months was safe and effective in controlling RAOM infections in a high-risk pediatric population."
2.	Urinary Tract Infections (Urinary Tract Infection) 08/08/1990 - "In over 6 months of observation, postcoital administration of trimethoprim-sulfamethoxazole was highly effective in preventing recurrent urinary tract infections. " 06/01/1985 - "Single-dose trimethoprim-sulfamethoxazole is as effective as ten-day treatment in women with symptoms suggestive of lower urinary tract infection and has no greater relapse rate." 01/01/2001 - "The aim of the study was to determine the efficacy of cotrimoxazole administration after urodynamic testing to prevent urinary tract infections. " 06/01/1988 - "Efficacy of five years of continuous, low-dose trimethoprim-sulfamethoxazole prophylaxis for urinary tract infection." 07/01/1981 - "The efficacy of a long-term prophylaxis with Co-trimoxazole was studied in 18 girls with recurrent urinary tract infections. "
3.	Pneumonia (Pneumonitis) 01/01/2006 - "Cotrimoxazole is cheap and effective against a wide range of organisms, including Pneumocystis jiroveci pneumonia (PCP), which is an important cause of death and illness in the first year of life. " 11/21/2001 - "Chemotherapeutic prophylaxis is very effective in preventing P carinii pneumonia; the combination of trimethoprim-sulfamethoxazole remains the first-line agent for both therapy and prophylaxis. " 01/01/1984 - "Trimethoprim sulfamethoxazole is very effective in the prevention of Pneumocystis carinii pneumonitis. " 09/01/1979 - "Trimethoprim-sulfamethoxazole has been proven effective in the treatment and prevention of Pneumocystis carinii pneumonitis in lower animals and humans. " 01/01/2005 - "Both standard and double strength cotrimoxazole were equally effective in treating non-severe pneumonia. "
4.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 11/01/1993 - "Trimethoprim-sulfamethoxazole administered orally daily or thrice weekly is highly effective for the prevention of Pneumocystis carinii pneumonia. " 01/01/2003 - "Cotrimoxazole is cheap and effective against a wide range of organisms, including Pneumocystis carinii pneumonia (PCP) which is an important cause of death and illness in the first year of life. " 10/01/2005 - "Prevention and treatment of Pneumocystis pneumonia with trimethoprim/sulfamethoxazole is effective in reducing this risk. " 07/01/1994 - "This preliminary study suggests that the efficacy of these regimens in preventing pneumocystis pneumonia, however, may be less than that of trimethoprim-sulfamethoxazole." 10/01/2003 - "Although several studies have reported that it is safe to discontinue secondary Pneumocystis carinii pneumonia (PCP) prophylaxis in patients infected with HIV who experience a sustained immune response as a result of antiretroviral therapy, we describe a patient who developed recurrent PCP <3 months after discontinuing trimethoprim-sulfamethoxazole prophylaxis. "
5.	Malaria 01/01/2011 - "Co-trimoxazole prophylaxis was moderately protective against malaria in HIV exposed infants when continued beyond the period of HIV exposure despite the high prevalence of Plasmodium genotypes associated with antifolate resistance. " 10/01/2007 - "The efficacy of TMP/SMX may be diminished where antifolate resistance to malaria is high. " 12/01/2014 - "Protective efficacy of prolonged co-trimoxazole prophylaxis in HIV-exposed children up to age 4 years for the prevention of malaria in Uganda: a randomised controlled open-label trial." 01/01/2015 - "Cotrimoxazole prophylaxis was strongly protective against the incidence of malaria when associated with ART in HIV-infected children. " 01/01/2011 - "To evaluate the protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children (uninfected children born to HIV infected mothers) in Africa. "

Related Drugs and Biologics

1.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
2.	Trimethoprim (Proloprim)
3.	Thymidine Monophosphate (TMP)
4.	Sulfamethoxazole
5.	Ampicillin (Omnipen)
6.	Rifampin (Rifampicin)
7.	Ciprofloxacin (Cipro)
8.	Norfloxacin
9.	Anti-Bacterial Agents (Antibiotics)
10.	Amoxicillin (Wymox)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Transplants (Transplant)
3.	Drug Therapy (Chemotherapy)
4.	Transplantation (Transplant Recipients)
5.	Chemoprevention