1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Also Known As:
1 Methyl 4 phenylpyridinium; 1-Methyl-4-phenylpyridine; 1-Methyl-4-phenylpyridinium Chloride; 1-Methyl-4-phenylpyridinium Ion; N-Methyl-4-phenylpyridine; N-Methyl-4-phenylpyridinium; 1 Methyl 4 phenylpyridine; 1 Methyl 4 phenylpyridinium Chloride; 1 Methyl 4 phenylpyridinium Ion; N Methyl 4 phenylpyridine; Cyperquat; Pyridinium, 1-methyl-4-phenyl-
Networked: 254
relevant articles (13 outcomes,
50 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Soliman, Karam F A:
6 articles
(06/2010 - 01/2003)
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2. | Bähr, Mathias:
4 articles
(11/2012 - 07/2004)
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3. | Lingor, Paul:
4 articles
(11/2012 - 07/2004)
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4. | Choi, Dong-Kug:
3 articles
(01/2013 - 01/2011)
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5. | Weishaupt, Jochen H:
3 articles
(11/2012 - 05/2006)
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6. | Soliman, K F A:
3 articles
(10/2012 - 02/2003)
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7. | Mazzio, E:
3 articles
(10/2012 - 02/2003)
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8. | Mazzio, Elizabeth A:
3 articles
(06/2010 - 03/2004)
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9. | Hillard, Cecilia J:
3 articles
(10/2005 - 04/2003)
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10. | Kalyanaraman, B:
3 articles
(10/2005 - 04/2003)
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Related Diseases
1. | Neuroblastoma
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2. | Parkinson Disease (Parkinson's Disease)
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3. | Pheochromocytoma
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4. | Parkinsonian Disorders (Parkinsonism)
07/01/2009
- " In this study we sought to determine whether H(C) also prevents the apoptosis induced by the mitochondrial poison 1-methyl-4-phenylpyridinium (MPP+), which induces a form of Parkinsonism. " 05/01/2013
- " 1-Methyl-4-phenylpyridinium (MPP(+) ), a potent parkinsonizing agent in primates and rodents, is a blocker of mitochondrial complex I, therefore MPP(+) -induced parkinsonism is believed to depend largely on mitochondrial impairment. " 01/09/2009
- " 1-methyl-4-phenylpyridinium ion (MPP(+)) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. " 01/01/2007
- " The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) produces mitochondria-targeted injury, which contributes to parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine in mammals. " 05/01/2005
- " The molecular mechanism of 1-methyl-4-phenylpyridinium (MPP+), a Parkinsonism-inducing neurotoxin, has been studied in PC12 cells. "
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5. | Necrosis
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