Magnesium Chloride

Magnesium chloride. An inorganic compound consisting of one magnesium and two chloride ions. The compound is used in medicine as a source of magnesium ions, which are essential for many cellular activities. It has also been used as a cathartic and in alloys.

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Networked: 305 relevant articles (22 outcomes, 44 trials/studies)

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Drug Context: Research Results

Experts

1.	Guerrero-Romero, Fernando: 6 articles (01/2022 - 04/2003)
2.	Rodríguez-Morán, Martha: 4 articles (05/2014 - 04/2003)
3.	Iezhitsa, I N: 4 articles (01/2013 - 08/2007)
4.	Kharitonova, M V: 4 articles (01/2013 - 08/2007)
5.	Kwon, Brian K: 3 articles (12/2016 - 08/2009)
6.	Spasov, A A: 3 articles (01/2013 - 08/2007)
7.	Kravchenko, M S: 3 articles (01/2010 - 08/2007)
8.	Hoane, Michael R: 3 articles (12/2007 - 01/2005)
9.	Alves, Beatriz da Costa Aguiar: 2 articles (09/2022 - 01/2022)
10.	Fonseca, Fernando Luiz Affonso: 2 articles (09/2022 - 01/2022)

Related Diseases

1.	Benign Familial Pemphigus (Hailey Hailey Disease) 03/01/2016 - "Efficacy of magnesium chloride in the treatment of Hailey-Hailey disease: some further considerations." 01/01/2015 - "Efficacy of magnesium chloride in the treatment of Hailey-Hailey disease: from serendipity to evidence of its effect on intracellular Ca(2+) homeostasis." 11/01/2020 - "Successful treatment of refractory Hailey-Hailey disease with oral magnesium chloride." 03/01/2017 - "Oral magnesium chloride: A novel approach in the management of Hailey-Hailey disease." 01/01/2020 - "Herein, we present a 63-year-old woman with long-standing and recurrent bilateral inguinal Hailey-Hailey disease who significantly improved with low-dose naltrexone and oral magnesium chloride, representing the third case described with this combination."
2.	Traumatic Brain Injuries (Traumatic Brain Injury) 03/20/1989 - "Our results suggest that postinjury treatment with MgCl2 is effective in limiting the extent of neurological dysfunction following experimental traumatic brain injury in the rat." 11/01/2000 - "The present study demonstrates that, in addition to its beneficial effects on behavioral outcome, MgCl2 treatment attenuates cortical histological damage when administered following traumatic brain injury." 11/01/2000 - "Postinjury treatment with magnesium chloride attenuates cortical damage after traumatic brain injury in rats." 07/01/1999 - "Alterations in ionized and total blood magnesium after experimental traumatic brain injury: relationship to neurobehavioral outcome and neuroprotective efficacy of magnesium chloride." 07/01/1999 - "When magnesium chloride (125 micromol/rat) was administered 1 h postinjury, ionized magnesium levels were restored by 2 h postinjury and remained at normal values up to 24 h following brain trauma. "
3.	Body Weight (Weight, Body) 01/01/2013 - "On day 49 of low Mg diet, Mg-deficient rats were randomly divided into four groups: 1) group that continued to receive low Mg diet; 2) low Mg diet plus oral MgSO4; 3) low Mg diet plus oral Mg-L-Asp and 4) low Mg diet plus oral MgCl2 (50 mg of Mg per kg of body weight). " 11/01/2010 - "A daily supplementation of 3.0 mmol of magnesium-chloride per kilogram of body weight was given to subjects in the SCS and SES groups. " 01/01/1991 - "These two substances were also administered jointly (K2C2O7-5 mg/kg and MgCl2-500 mg/kg of body weight). " 02/01/1988 - "The author suggested that the dose of Mg be 0.4 mEq/kg body weight/day, as 50% MgSO4.7H2O intramuscularly (IM) for 5 days; or as 1.0 mEq/kg/day, as 10% MgCl2.6H2O by mouth for 2 or more weeks, with appropriate monitoring of plasma Mg values in all infants. " 09/01/1975 - "White Leghorn male chicks, 2-6 days and 4 weeks old, were injected with MgCl2 (2 mM Mg/kg body weight) and exposed to 100% O2 at 75 lb/in2 (approximately 5 atm). "
4.	Neoplasms (Cancer) 09/01/2022 - "Comparative Study on the Effects of Paullinia cupana, PC-18 and Magnesium Chloride on Solid Ehrlich Tumor." 09/01/1982 - "However, after desaturating receptors by treatment with 3.2 M MgCl2 for 5 min, bovine GH binding to membranes from tumor-bearing males was 3-fold higher than in normal males, while in tumor-bearing females binding was more than twice as high as in normal females. " 11/01/1934 - "THE VALUE OF MAGNESIUM CHLORIDE AS AN AID IN THE TREATMENT OF CANCER: A Preliminary Report." 01/01/2020 - "In conclusion, the accurate utilization of MgCl2 in targeting autophagy might be beneficial in cancer therapy. " 04/01/1999 - "Findings of this study suggest that: i) instead of directly adopting published RAPD protocol it is essential to optimize RAPD reaction conditions by varying magnesium chloride and polymerase concentration with different amounts of DNA templates in order to observe reproducible fingerprints of randomly amplified polymorphic DNA fragments, ii) alterations in the genome as a loss, gain, or decrease and increase in amplification intensity of loci were observed in human tumors as well as in an experimental animal tumor, and iii) before concluding that a mutation is not present when using RAPD/AP-PCR, different polymerases should be used to amplify the genome of the same control or tumor tissues."
5.	Brain Injuries (Brain Injury) 01/01/2005 - "Previous studies have shown that administration of MgCl2 in animal models of brain injury significantly improves functional recovery: however, few studies have examined cognitive recovery. " 12/01/2007 - "Mg2+ therapy for brain injury revealed that administration of post-injury MgCl2 effectively improved recovery of cognitive deficits following injury. " 04/01/1999 - "Twenty minutes after fluid percussion (FP) brain injury of moderate severity (2.2-2.4 atm), anesthetized rats received a 15-min intravenous infusion of either 125 mumol of MgCl2 or vehicle, followed 5 min later by a 24-h constant intravenous infusion of either bFGF (16 micrograms/h) or vehicle. " 01/01/1998 - "Moreover, to observe the beneficial effects of MgCl2, the timing of injections need not be tied to the period immediately around the brain injury. " 11/01/2000 - "The neuroprotective effect of magnesium chloride (MgCl2), a compound previously demonstrated to improve behavioral and neurochemical outcome in several models of experimental brain injury, was evaluated in the present study. "

Related Drugs and Biologics

1.	Magnesium
2.	Salts
3.	Aspartic Acid (Aspartate)
4.	Adenosine Triphosphate (ATP)
5.	Phosphorus (Red Phosphorus)
6.	Riluzole
7.	Calcium
8.	Saline Solution
9.	Therapeutic Uses
10.	Verapamil (Calan)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Induced Heart Arrest (Cardioplegia)
4.	Anesthesia
5.	Drug Therapy (Chemotherapy)