Magnesium Chloride

Magnesium chloride. An inorganic compound consisting of one magnesium and two chloride ions. The compound is used in medicine as a source of magnesium ions, which are essential for many cellular activities. It has also been used as a cathartic and in alloys.

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Networked: 231 relevant articles (14 outcomes, 30 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Iezhitsa, I N: 4 articles (01/2013 - 08/2007)
2.	Kharitonova, M V: 4 articles (01/2013 - 08/2007)
3.	Spasov, A A: 3 articles (01/2013 - 08/2007)
4.	Kravchenko, M S: 3 articles (01/2010 - 08/2007)
5.	Hoane, Michael R: 3 articles (12/2007 - 01/2005)
6.	Guerrero-Romero, Fernando: 2 articles (05/2014 - 06/2010)
7.	Kwon, Brian K: 2 articles (10/2010 - 08/2009)
8.	Engen, Deborah J: 1 article (09/2015)
9.	Dion, Liza J: 1 article (09/2015)
10.	Cha, Stephen S: 1 article (09/2015)

Related Diseases

1.	Brain Injuries (Brain Injury) 03/20/1989 - "Our results suggest that postinjury treatment with MgCl2 is effective in limiting the extent of neurological dysfunction following experimental traumatic brain injury in the rat." 12/01/2007 - "Mg2+ therapy for brain injury revealed that administration of post-injury MgCl2 effectively improved recovery of cognitive deficits following injury. " 01/01/2005 - "Previous studies have shown that administration of MgCl2 in animal models of brain injury significantly improves functional recovery: however, few studies have examined cognitive recovery. " 11/01/2000 - "The present study demonstrates that, in addition to its beneficial effects on behavioral outcome, MgCl2 treatment attenuates cortical histological damage when administered following traumatic brain injury." 11/01/2000 - "The neuroprotective effect of magnesium chloride (MgCl2), a compound previously demonstrated to improve behavioral and neurochemical outcome in several models of experimental brain injury, was evaluated in the present study. "
2.	Heart Failure 03/01/1998 - "Time to 90% repolarization was significantly shorter in cells dialyzed with 1.0 mmol/liter compared with 0.5 mmol/liter MgCl2 in myocytes from normal dogs or dogs with heart failure (596 +/- 34 vs. 760 +/- 58 ms in normal dogs and 586 +/- 29 vs. 838 +/- 98 ms in dogs with heart failure; p < 0.05 for each). " 12/01/1995 - "Two recent randomized, double blind, placebo-controlled trials have shown that both intravenous and oral administration of magnesium chloride results in a significant reduction in the frequency and complexity of ventricular arrhythmias in patients with congestive heart failure. " 02/01/1994 - "Intravenous magnesium chloride administration reduces the frequency of ventricular arrhythmia in patients with symptomatic heart failure." 02/01/1994 - "We studied the acute effect of intravenous magnesium chloride on the frequency and severity of ventricular arrhythmia in 30 patients with symptomatic heart failure using a double-blind, placebo-controlled crossover design. " 11/15/1993 - "Effects of long-term oral magnesium chloride replacement in congestive heart failure secondary to coronary artery disease."
3.	Alzheimer Disease (Alzheimer's Disease) 02/15/1995 - "In contrast, MgCl2 enhanced [3H]OXO-M binding was significantly higher in Alzheimer's disease superior temporal cortex, compared to controls. " 02/15/1995 - "MgCl2 gave similar enhancements of [3H]OXO-M binding in Alzheimer's disease and control occipital cortex. " 04/01/1991 - "In this study we show that tau in extracts of Alzheimer's disease brain can be separated into two fractions based upon its solubility (100,000 g x 1 h supernatant) in non-denaturing conditions (100 mM-Mes, pH 6.5, 0.5 mM-MgCl2, 1 mM-EGTA and 1 M-NaCl). " 02/15/1995 - "MgCl2 enhanced [3H]OXO-M binding in both the occipital and temporal cortices of the Alzheimer's disease cases was reversed to control levels by Gpp[NH]p. " 01/01/1999 - "Immunoaffinity-purified paired helical filaments (PHFs) from Alzheimer's disease (AD) brain homogenates contain an associated protein kinase activity that is able to induce the phosphorylation of PHF proteins on addition of exogenous MgCl2 and ATP. "
4.	Diffuse Axonal Injury 03/01/1998 - "The present study compares the neuroprotective efficacy of MgSO4 and MgCl2 in a severe model of diffuse axonal injury in rats using phosphorus nuclear magnetic resonance spectroscopy and the rotarod test to monitor effects on metabolism and neurologic outcome, respectively. " 03/01/1998 - "These earlier studies, however, have been limited to models of injury that do not produce a significant degree of diffuse axonal injury and have used either MgSO4 or MgCl2 as the magnesium salt. "
5.	Closed Head Injuries 03/01/1998 - "Both MgSO4 and MgCl2 given as a bolus of 100 micromoles/kg at 30 min after severe, closed head injury significantly improved brain intracellular free magnesium concentration and neurologic outcome. " 03/01/1998 - "Neuroprotective effects of MgSO4 and MgCl2 in closed head injury: a comparative phosphorus NMR study."

Related Drugs and Biologics

1.	Magnesium
2.	Adenosine Triphosphate (ATP)
3.	Phosphorus
4.	Calcium
5.	Verapamil (Calan)
6.	Potassium Chloride
7.	Muscarinic M2 Receptor
8.	GTP-Binding Proteins (G-Protein)
9.	Ritodrine (Yutopar)
10.	Halothane (Fluothane)

Related Therapies and Procedures

1.	Oral Administration
2.	Induced Heart Arrest (Cardioplegia)
3.	Anesthesia
4.	Drug Therapy (Chemotherapy)
5.	Transplants (Transplant)