Non-Langerhans-Cell Histiocytosis (Histiocytosis, Non Langerhans Cell)

Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; JUVENILE XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES).

Also Known As:

Networked: 35 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Histiocytosis
2.	Sinus Histiocytosis (Rosai-Dorfman Disease)
3.	Histiocytoma
4.	Non-Langerhans-Cell Histiocytosis (Histiocytosis, Non Langerhans Cell)
5.	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell)

Experts

1.	Williams, Abhilasha: 1 article (07/2015)
2.	Thomas, Abraham G: 1 article (07/2015)
3.	Jain, Kunal: 1 article (07/2015)
4.	Kwatra, Kanwardeep Singh: 1 article (07/2015)
5.	Schwartz, Erich J: 1 article (02/2015)
6.	Mirzamani, Neda: 1 article (02/2015)
7.	Mizramani, Neda: 1 article (02/2015)
8.	Vanchinathan, Vijay: 1 article (02/2015)
9.	Sundram, Uma N: 1 article (02/2015)
10.	Kantipudi, Ramya: 1 article (02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Non-Langerhans-Cell Histiocytosis:

1.	CladribineFDA LinkGeneric 04/01/2011 - "Therapy with 2-chlorodeoxyadenosine was effective at inducing remission and long-term control of cutaneous lesions of xanthoma disseminatum in 5 cases. " 04/01/2011 - "Among 8 cases of xanthoma disseminatum, a positive response to treatment with 2-chlorodeoxyadenosine was seen in 5 cases." 04/01/2011 - "Xanthoma disseminatum: effective therapy with 2-chlorodeoxyadenosine in a case series." 12/01/2009 - "Both entities regressed under cladribine, with only mild relapses of the non-Langerhans' cell histiocytosis involvements."
2.	imatinib (Gleevec)FDA Link 05/01/2009 - "Rosai-Dorfman disease is a non-Langerhans cell histiocytosis that recently has been treated successfully with imatinib mesylate in a patient with a systemic variant of the disease. "
3.	lithocholyl-N-hydroxysuccinimideIBA 07/01/2015 - "Progressive nodular histiocytosis (PNH) is a rare normolipemic macrophage disorder and belongs to a subgroup of non-Langerhans cell histiocytosis (LCHs) which is characterized by a progressive course with no sign of spontaneous resolution but without systemic involvement. "
4.	Hematoxylin (Haematoxylon)IBA 03/01/2014 - "Hematoxylin and eosin staining and immunoperoxidase studies of the biopsy specimen established the diagnosis of adult-onset reticulohistiocytoma (solitary epithelioid histiocytoma). "
5.	Eosine Yellowish-(YS) (Eosin)IBA 03/01/2014 - "Hematoxylin and eosin staining and immunoperoxidase studies of the biopsy specimen established the diagnosis of adult-onset reticulohistiocytoma (solitary epithelioid histiocytoma). "
6.	Muramidase (Lysozyme)IBA 04/01/1984 - "[Xanthoma disseminatum--differentiation from histiocytosis X with immunohistochemical demonstration of S100 protein, lysozyme and NCA]." 12/01/1987 - "Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 1-AT)] in biopsied tissues from histiocytosis X, juvenile xanthogranuloma, xanthoma tuberosum, xanthoma disseminatum, reticulohistiocytic granuloma and multicentric reticulohistiocytoma, all of which have been classified as histiocytic proliferative disorders. " 09/01/1992 - "The use of immunocytochemical markers for S100 protein, factor XIIIa, lysozyme, alpha 1-antitrypsin, for adherence of peanut agglutinin and of antibodies LN3 (HLA-DR), Leu-M1 (CD15), QBEnd/10 (CD34), MAC 387, and KP1 (CD68) as an aid to conventional histology has been studied in routinely fixed skin biopsy specimens from seven patients with xanthoma disseminatum and 12 patients with histiocytosis X. Typically xanthoma disseminatum occurs in discrete foci below an intact epidermis with individual cells set within a delicate fibrillary connective tissue stroma. "
7.	AntibodiesIBA 03/01/1995 - "The antibodies against factor XIIIa (shown on xanthoma disseminatum) and the monoclonal antibody Ki-M1P (shown on juvenile xanthogranuloma) seem to be valuable in discrimination between LCH and non-LCH. " 02/01/2015 - "We examined eight epithelioid cell histiocytomas (ECHs), 12 xanthogranulomas (XGs), nine cases of Langerhans cell histiocytosis (LCH), eight reticulohistiocytomas, 11 xanthomas, 29 atypical fibroxanthomas, nine granular cell tumors, four cases of angiolymphoid hyperplasia with eosinophilia, nine intradermal Spitz nevi, and nine angiosarcomas with antibodies directed against CD31, CD34, CD163, and factor VIII. CD31 marked cells in three of 12 XGs, four of nine cases of LCH, one of eight reticulohistiocytomas, one of 11 xanthomas, 10 of 29 atypical fibroxanthomas, four of four cases of angiolymphoid hyperplasia with eosinophilia, nine of nine angiosarcomas, zero of nine granular cell tumors, and zero of eight ECHs. " 09/01/1992 - "The use of immunocytochemical markers for S100 protein, factor XIIIa, lysozyme, alpha 1-antitrypsin, for adherence of peanut agglutinin and of antibodies LN3 (HLA-DR), Leu-M1 (CD15), QBEnd/10 (CD34), MAC 387, and KP1 (CD68) as an aid to conventional histology has been studied in routinely fixed skin biopsy specimens from seven patients with xanthoma disseminatum and 12 patients with histiocytosis X. Typically xanthoma disseminatum occurs in discrete foci below an intact epidermis with individual cells set within a delicate fibrillary connective tissue stroma. "
8.	Factor XIIIaIBA 09/01/1992 - "Most xanthoma disseminatum cells labeled strongly for factor XIIIa and with KP1; a few cells labeled only weakly with peanut agglutinin. " 03/01/1995 - "The antibodies against factor XIIIa (shown on xanthoma disseminatum) and the monoclonal antibody Ki-M1P (shown on juvenile xanthogranuloma) seem to be valuable in discrimination between LCH and non-LCH. " 09/01/1992 - "The use of immunocytochemical markers for S100 protein, factor XIIIa, lysozyme, alpha 1-antitrypsin, for adherence of peanut agglutinin and of antibodies LN3 (HLA-DR), Leu-M1 (CD15), QBEnd/10 (CD34), MAC 387, and KP1 (CD68) as an aid to conventional histology has been studied in routinely fixed skin biopsy specimens from seven patients with xanthoma disseminatum and 12 patients with histiocytosis X. Typically xanthoma disseminatum occurs in discrete foci below an intact epidermis with individual cells set within a delicate fibrillary connective tissue stroma. "
9.	Vinblastine (Vinblastine Sulfate)FDA Link 03/01/2004 - "[Vinblastine treatment for extensive non-X histiocytosis (xanthoma disseminatum)]." 12/01/2009 - "Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently. "
10.	S100 Proteins (S 100 Protein)IBA 07/01/2012 - "Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis whose hallmark is tissue infiltration by CD68-positive, CD1a-negative and usually S-100 protein-positive foamy non-Langerhans histiocytes and mononuclear cells. " 01/01/1986 - "To better define the roles of S-100 protein immunohistochemistry and electron microscopy in the diagnosis of Langerhans cell proliferative disorders, a comparative assessment of the two techniques was performed using material from 39 cases of histiocytosis X and 2 cases of infantile self-healing reticulohistiocytoma. "

Therapies and Procedures

1.	Dye Lasers 05/01/2004 - "In our case report the use of the pumped pulsed dye-laser has proven to be an elegant and low risk treatment option for reticulohistiocytoma. " 05/01/2004 - "We successfully treated a histologically confirmed reticulohistiocytoma on the back of a 60 year old woman with a pulsed dye-laser (wavelength 585 nm, pulse 0.45 msec). "
2.	Semiconductor Lasers 12/01/2014 - "Nonablative 1,450-nm diode laser treatment for xanthoma disseminatum."
3.	Gas Lasers 10/01/1999 - "Treatment of cutaneous lesions of xanthoma disseminatum with a CO2 laser."
4.	Lasers (Laser) 03/01/2001 - "Bilateral laryngeal pseudoparalysis in xanthoma disseminatum treated by endoscopic laser medial arytenoidectomy."
5.	Knee Prosthesis 05/01/2012 - "These findings were interpreted as consistent with a reactive, non-Langerhans cell histiocytosis secondary to the patient's polyethylene knee prosthesis. "