Non-Langerhans-Cell Histiocytosis (Histiocytosis, Non Langerhans Cell)

Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; JUVENILE XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES).
Also Known As:
Histiocytosis, Non Langerhans Cell; Reticulohistiocytoma; Histiocytosis, Non-Langerhans-Cell; Disseminatum, Xanthoma; Reticulohistiocytomas; Xanthoma Disseminatum
Networked: 35 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Histiocytosis
2. Sinus Histiocytosis (Rosai-Dorfman Disease)
3. Histiocytoma
4. Non-Langerhans-Cell Histiocytosis (Histiocytosis, Non Langerhans Cell)
5. Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell)


1. Williams, Abhilasha: 1 article (07/2015)
2. Thomas, Abraham G: 1 article (07/2015)
3. Jain, Kunal: 1 article (07/2015)
4. Kwatra, Kanwardeep Singh: 1 article (07/2015)
5. Schwartz, Erich J: 1 article (02/2015)
6. Mirzamani, Neda: 1 article (02/2015)
7. Mizramani, Neda: 1 article (02/2015)
8. Vanchinathan, Vijay: 1 article (02/2015)
9. Sundram, Uma N: 1 article (02/2015)
10. Kantipudi, Ramya: 1 article (02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Non-Langerhans-Cell Histiocytosis:
1. CladribineFDA LinkGeneric
2. imatinib (Gleevec)FDA Link
3. lithocholyl-N-hydroxysuccinimideIBA
4. Hematoxylin (Haematoxylon)IBA
5. Eosine Yellowish-(YS) (Eosin)IBA
6. Muramidase (Lysozyme)IBA
7. AntibodiesIBA
03/01/1995 - "The antibodies against factor XIIIa (shown on xanthoma disseminatum) and the monoclonal antibody Ki-M1P (shown on juvenile xanthogranuloma) seem to be valuable in discrimination between LCH and non-LCH. "
02/01/2015 - "We examined eight epithelioid cell histiocytomas (ECHs), 12 xanthogranulomas (XGs), nine cases of Langerhans cell histiocytosis (LCH), eight reticulohistiocytomas, 11 xanthomas, 29 atypical fibroxanthomas, nine granular cell tumors, four cases of angiolymphoid hyperplasia with eosinophilia, nine intradermal Spitz nevi, and nine angiosarcomas with antibodies directed against CD31, CD34, CD163, and factor VIII. CD31 marked cells in three of 12 XGs, four of nine cases of LCH, one of eight reticulohistiocytomas, one of 11 xanthomas, 10 of 29 atypical fibroxanthomas, four of four cases of angiolymphoid hyperplasia with eosinophilia, nine of nine angiosarcomas, zero of nine granular cell tumors, and zero of eight ECHs. "
09/01/1992 - "The use of immunocytochemical markers for S100 protein, factor XIIIa, lysozyme, alpha 1-antitrypsin, for adherence of peanut agglutinin and of antibodies LN3 (HLA-DR), Leu-M1 (CD15), QBEnd/10 (CD34), MAC 387, and KP1 (CD68) as an aid to conventional histology has been studied in routinely fixed skin biopsy specimens from seven patients with xanthoma disseminatum and 12 patients with histiocytosis X. Typically xanthoma disseminatum occurs in discrete foci below an intact epidermis with individual cells set within a delicate fibrillary connective tissue stroma. "
8. Factor XIIIaIBA
9. Vinblastine (Vinblastine Sulfate)FDA Link
10. S100 Proteins (S 100 Protein)IBA

Therapies and Procedures

1. Dye Lasers
2. Semiconductor Lasers
3. Gas Lasers
4. Lasers (Laser)
5. Knee Prosthesis