Histiocytosis

General term for the abnormal appearance of histiocytes in the blood. Based on the pathological features of the cells involved rather than on clinical findings, the histiocytic diseases are subdivided into three groups: HISTIOCYTOSIS, LANGERHANS CELL; HISTIOCYTOSIS, NON-LANGERHANS-CELL; and HISTIOCYTIC DISORDERS, MALIGNANT.

Also Known As:

Networked: 321 relevant articles (11 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Lymphoma (Lymphomas)
3.	Heart Failure
4.	Sarcoidosis (Schaumann Disease)
5.	Leukemia

Experts

1.	Perkins, Michael W: 2 articles (06/2014 - 12/2013)
2.	Sciuto, Alfred M: 2 articles (06/2014 - 12/2013)
3.	Govindarajan, Rajgopal: 2 articles (01/2012 - 09/2010)
4.	Rudzki, Zbigniew: 2 articles (01/2011 - 07/2004)
5.	Colby, Thomas V: 2 articles (08/2007 - 09/2005)
6.	Goerdt, Sergij: 2 articles (06/2007 - 11/2003)
7.	Mahvelati, Farhad: 2 articles (05/2007 - 11/2006)
8.	Tonekaboni, Hassan: 2 articles (05/2007 - 11/2006)
9.	Ghofrani, Mohammad: 2 articles (05/2007 - 11/2006)
10.	Miyauchi, T: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Histiocytosis:

1.	Etoposide (VP 16)FDA LinkGeneric 06/01/1990 - "Additionally, VP-16 is considered to be effective for the treatment of histiocytosis." 05/01/1994 - "VP-16 and the treatment of histiocytosis." 01/01/1994 - "Data on the risk of etoposide-associated (therapy-induced) malignancy, in the setting of histiocytosis, are reviewed. " 06/01/1990 - "The efficacy rate for VP-16 alone was 87.5% for primary cases of ANLL and 100% for primary cases of histiocytosis. " 09/01/1991 - "The results suggested that the treatment with etoposide might be effective for reactive histiocytosis and the related refractory state to platelet transfusion during therapy for leukemia."
2.	bortezomib (Velcade)FDA Link 11/01/2015 - "Complete remission of Waldenström's associated generalized crystal-storing histiocytosis of IgM lambda subtype with bortezomib-based combination chemotherapy." 08/01/2012 - "Bortezomib combined with thalidomide and dexamethasone is effective for patient with crystal-storing histiocytosis associated with monoclonal gammopathy of undermined significance."
3.	Thalidomide (Thalomid)FDA Link 04/01/2012 - "Indeterminate cell histiocytosis in a pediatric patient: successful treatment with thalidomide." 07/01/2011 - "Langerhans cells histiocytosis with vulvar involvement and responding to thalidomide therapy--case report." 07/01/2002 - "Cutaneo-mucous Langerhans cell disease as well as hypothalamo-hypophyseal histiocytosis may both benefit from a treatment with thalidomide." 07/01/2001 - "These observations confirm thalidomide efficacy in myeloma, suggest a possible use in MDS and histiocytosis and may contribute to the prediction of clinical response and to understanding the mechanism of thalidomide's action." 03/01/1998 - "[Langerhans histiocytosis in adults: cutaneous and mucous lesion regression after treatment with thalidomide]."
4.	CladribineFDA LinkGeneric 01/01/1997 - "Indeterminate cell histiocytosis treated successfully with 2-chlorodeoxyadenosine." 09/01/2008 - "Aggressive intermediate cell histiocytosis successfully treated by 2-chlorodeoxyadenosine." 03/01/2015 - "Cladribine improves lung cysts and pulmonary function in a child with histiocytosis."
5.	Vinblastine (Vinblastine Sulfate)FDA Link 11/01/1982 - "Response of nodular non-X histiocytosis to vinblastine." 03/01/2004 - "[Vinblastine treatment for extensive non-X histiocytosis (xanthoma disseminatum)]." 03/01/1970 - "[Remission of acute histiocytosis with lung involvement after treatment with vinblastine and prednisone]."
6.	Prednisone (Sone)FDA LinkGeneric 03/01/1970 - "[Remission of acute histiocytosis with lung involvement after treatment with vinblastine and prednisone]." 06/01/1977 - "A patient with systemic histiocytosis was treated with hemibody irradiation, vincristine, and prednisone. "
7.	Immunoglobulin M (IgM)IBA 06/01/2011 - "Crystal-storing histiocytosis in ascites from a patient with IgM kappa lymphoplasmacytic lymphoma." 11/01/2015 - "Complete remission of Waldenström's associated generalized crystal-storing histiocytosis of IgM lambda subtype with bortezomib-based combination chemotherapy."
8.	LanthanumIBA 04/01/2015 - "Symptoms and histiocytosis improved after discontinuation of lanthanum. " 04/01/2015 - "Lanthanum may be an underdiagnosed cause of gastrointestinal histiocytosis. " 04/01/2015 - "Lanthanum-Induced Gastrointestinal Histiocytosis."
9.	FuraginIBA 01/01/1999 - "Further 19 positive results were found in a group of 251 patients with other diseases: 1 of 4 pts with Churg-Strauss syndrome, 1 of 2 with pulmonary renal syndrome, 5 of 28 with connective tissue diseases, 1 of 21 with tuberculosis, 1 of 23 with sarcoidosis, 1 of 6 with histiocytosis, 3 of 11 with hypersensitivity pneumonitis, 1 (lymphoma) of 34 with neoplasms, 1 of 20 with pulmonary fibrosis, 1 of 8 with cardiac failure, 1 of 5 with pleural fluid, 1 of 10 pneumoconiosis and toxic reactions (after furagin), 1 of 6 with BOOP. "
10.	Dexamethasone (Maxidex)FDA LinkGeneric 08/01/2012 - "Bortezomib combined with thalidomide and dexamethasone is effective for patient with crystal-storing histiocytosis associated with monoclonal gammopathy of undermined significance."

Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy) 08/01/1977 - "This is the second study of combination chemotherapy with individually effective agents that has failed to improve the response rates in histiocytosis patients with poor prognostic indicators." 11/01/2015 - "Complete remission of Waldenström's associated generalized crystal-storing histiocytosis of IgM lambda subtype with bortezomib-based combination chemotherapy."
2.	Drug Therapy (Chemotherapy) 05/01/2007 - "He received chemotherapy for histiocytosis that was diagnosed when he was 3 years, 6 months years old. " 11/01/2006 - "He received chemotherapy for histiocytosis and was diagnosed at 3.5 years. " 02/01/2004 - "We suggest that chemotherapy should be considered at an early stage in the more aggressive subtypes of non-Langerhans cell histiocytoses." 12/01/1992 - "Thus, reactive histiocytosis is one of the severe complications in patients with AML undergoing chemotherapy." 01/01/1981 - "Chemotherapy of histiocytosis."
3.	Aftercare (After-Treatment) 01/01/1977 - "On the occasion of a second lung biopsy in one case could be seen that after treatment no more histiocytosis-specific substrate was existing. " 03/01/1998 - "[Langerhans histiocytosis in adults: cutaneous and mucous lesion regression after treatment with thalidomide]." 03/01/1970 - "[Remission of acute histiocytosis with lung involvement after treatment with vinblastine and prednisone]."
4.	Platelet Transfusion (Blood Platelet Transfusions) 09/01/1991 - "The results suggested that the treatment with etoposide might be effective for reactive histiocytosis and the related refractory state to platelet transfusion during therapy for leukemia." 09/01/1991 - "[Effectiveness of etoposide on reactive histiocytosis and refractory state to platelet transfusion during therapy of leukemia: case report]."
5.	Bandages (Bandage) 01/01/2011 - "Pressure bandage as an effective treatment for intralymphatic histiocytosis associated with rheumatoid arthritis."