Overdose

08/01/2007 - "Evaluation of 12 years of acute APAP overdoses suggests that the use of AC, in addition to NAC therapy, may provide improved patient outcomes."
11/01/2012 - "The annual incidence of paracetamol overdoses was high in this population-based study but declined. "
10/01/2007 - "Acetaminophen and antidepressant overdoses increased during the study period, whereas overdoses of minor tranquilizers decreased. "
08/01/2003 - "Paracetamol overdoses declined towards the end of the study period. "
08/01/1996 - "During the final six years of the study period paracetamol was involved in 54.7% of overdoses, compared with 19.5% in 1976-1981. "

01/01/2014 - "This study shows that acute overdoses with thiopurines have a favourable outcome in the majority of cases and provides preliminary evidence that gastrointestinal decontamination with activated charcoal may reduce symptom development after overdose of these substances if patients present to medical services soon after ingestion."
07/01/2010 - "There are clinical trials, research and position statements that have examined the effectiveness of activated charcoal in a number of overdoses of different medications, but there is still a debate surrounding the evidence based practice of administering activated charcoal in patients who have taken a drug overdose due to lack of evidence. "
01/01/2004 - "Additional study is required to determine whether in patients with anticholinergic drug overdose, activated charcoal is effective at times beyond the recommendation for overdoses of drugs without this pharmacodynamic effect."
01/01/1987 - "These findings support previous in vitro and human volunteer studies advocating the rapid administration of activated charcoal in acute tricyclic antidepressant overdoses."
09/01/2010 - "In addition, the charcoal cookie was rated as more palatable than the aqueous charcoal suspension, suggesting that the charcoal cookie could be an attractive alternative to the charcoal slurry for managing drug overdoses."

01/01/2013 - "Naloxone distribution was cost-effective in all deterministic and probabilistic sensitivity and scenario analyses, and it was cost-saving if it resulted in fewer overdoses or emergency medical service activations. "
05/01/2014 - "The current evidence from nonrandomized studies suggests that bystanders (mostly opioid users) can and will use naloxone to reverse opioid overdoses when properly trained, and that this training can be done successfully through OOPPs. "
03/01/2010 - "This study proposes that intranasal (IN) naloxone administration is preferable to intravenous (IV) naloxone by emergency medical services for opioid overdoses. "
07/01/2015 - "We determined the factors that affect naloxone (Narcan) administration in drug overdoses, including the certification level of emergency medical technicians (EMTs). "
05/01/2015 - "The program reached a high-risk population that commonly witnessed overdoses and that called for help and used naloxone, when available, to rescue people. "

04/01/1992 - "Several reports indicate a significant increase in the prescribing of benzodiazepine substitutes that are less safe and effective, along with increased overdoses of some substitute drugs. "
12/01/2015 - "A substantial proportion of these deaths involve opioid or benzodiazepine drugs, and many overdoses include a combination of both drug classes. "
11/01/2014 - "Although most benzodiazepine overdoses are known to be safe and nonfatal without coingestions, morbidity or mortality after benzodiazepine overdose is closely related with the duration of unconsciousness or depth of compromised airway. "
09/01/2014 - "Regardless of the definition, more than 53% of the hospitalizations were self-inflicted drug overdoses; benzodiazepines were involved in about 30% of the hospitalizations. "
07/05/2013 - "The prominent involvement of psychotherapeutic drugs, such as benzodiazepines, among overdoses provides insight for prevention opportunities. "

06/01/2014 - "This protocol delivers a higher dose of acetylcysteine which may be useful in selected cases involving very large overdoses."
11/01/2011 - "Further case details regarding IV N-acetylcysteine overdoses."
03/01/2008 - "Calls referred to NPIS consultants pertain mainly to patients who present late, staggered overdoses, adverse reactions to N-acetylcysteine, and interpretation of blood results. "
02/01/1991 - "While N-acetylcysteine is protective, an additional effective mode of treatment is desirable in large overdoses. "
08/01/2008 - "Unintentional overdoses (odds ratio [OR], 5.18; 95% confidence interval [CI], 3.00-8.95), alcohol abuse (OR, 2.21; 95% CI, 1.30-3.76), underlying liver disease (OR, 3.50; 95% CI, 1.57-7.77), and N-acetylcysteine treatment (OR, 6.75; 95% CI, 2.78-16.39) were independently associated with hepatotoxicity. "

10/01/2015 - "Since the safety and efficacy of buprenorphine are well documented, and overdoses resulting from buprenorphine treatment or diversion are very rare, facilitating access to buprenorphine treatment is strongly recommended."
10/01/2015 - "Buprenorphine is an opioid agonist medication that is both safe and effective in the treatment of opioid use disorders and the prevention of opioid overdoses. "
04/01/2008 - "The purpose of this study was to analyze buprenorphine overdoses in young children reported by US poison centers to the Researched Abuse, Diversion, and Addiction-Related Surveillance System. "
10/01/2015 - "To address the possible contribution of buprenorphine to overdose mortality, we systematically tested post mortem blood specimens from decedents who had died of an unintentional drug overdoses in 2013. "
02/01/2015 - "In terms of illicit OSD use being a risk factor for non-lethal overdoses, our results showed significant associations only for infrequent buprenorphine use (using once or less than once per week). "

09/01/2015 - "Some sedative overdoses can be treated with flumazenil, a reversal agent, along with supportive care. "
01/01/1991 - "From the knowledge and experience gained to date, it was concluded that flumazenil may be useful and safe in the treatment of suspected BZD and mixed drug overdoses, provided that the appropriate precautions are observed."
01/01/1991 - "A conference of experts experienced in the treatment of mixed drug overdoses by various means, including flumazenil, was held in order to try to reach a consensus regarding the safe use of flumazenil in this indication. "
02/01/1988 - "From all these toxicological investigations it can be concluded that the risk in man given therapeutic doses or even intentional or accidental overdoses of flumazenil is extremely small."
01/01/1991 - "Flumazenil is indicated for the reversal of the centrally depressant effects of BZDs, in BZD-induced anaesthesia, in BZD sedation in intensive care and in patients comatose after drug overdoses including BZDs. "

09/01/1985 - "Physostigmine is an approved antidote in the treatment of intoxication as well as in the management of overdoses of numerous medications--many of which are used in the course of pre-medication or anesthesia induction or maintenance. "
03/01/2005 - "Despite this, physostigmine has been proposed as an arousal agent to treat coma from overdoses of GHB. "
01/01/1977 - "Moderate and severe overdoses will require respiratory support, anticonvulsants, physostigmine, and beta-blockers. "
03/01/1983 - "the present results show that although physostigmine may be helpful in the treatment of central anticholinergic effects caused by overdoses of orphenadrine and imipramine it is of no use for combating the direct toxic effects of both drugs on the cardiovascular system."
03/01/1982 - "The influence of physostigmine on respiratory and circulatory changes caused by overdoses of orphenadrine or imipramine in the rat."

01/10/1998 - "There are numerous reports of deaths following orphenadrine overdoses. "
03/01/1983 - "the present results show that although physostigmine may be helpful in the treatment of central anticholinergic effects caused by overdoses of orphenadrine and imipramine it is of no use for combating the direct toxic effects of both drugs on the cardiovascular system."
03/01/1982 - "The influence of physostigmine on respiratory and circulatory changes caused by overdoses of orphenadrine or imipramine in the rat."
03/01/1982 - "Although physostigmine may be useful in the treatment of the anticholinergic syndrome it has, at least in the rat, no favourable effect on the respiratory insufficiency, due to overdoses of orphenadrine and imipramine. "

01/01/1992 - "From these results, it appears that PGF2 alpha has no effect on the absorption and exsorption of imipramine across the intestinal membrane although it is reasonable to use PGF2 alpha in the case of patients with overdoses of drugs which decrease gastrointestinal motility."
03/01/1983 - "the present results show that although physostigmine may be helpful in the treatment of central anticholinergic effects caused by overdoses of orphenadrine and imipramine it is of no use for combating the direct toxic effects of both drugs on the cardiovascular system."
03/01/1982 - "The influence of physostigmine on respiratory and circulatory changes caused by overdoses of orphenadrine or imipramine in the rat."
03/01/1982 - "Although physostigmine may be useful in the treatment of the anticholinergic syndrome it has, at least in the rat, no favourable effect on the respiratory insufficiency, due to overdoses of orphenadrine and imipramine. "

11/01/2009 - "Emergency hemodialysis may also be life-saving for patients who have received drug overdoses or have ingested toxic substances. "
11/01/2000 - "There were 174 acute on chronic overdoses; hemodialysis was recommended in 9 patients but only 6 underwent hemodialysis; one patient died during hemodialysis but no other had sequel. "
01/01/2012 - "Hemodialysis (HD) is a technique that helps in the management of drug intoxications/overdoses - the most important point being the protein-binding rate of the molecules which have to be cleared. "
11/01/2000 - "There were 12 acute lithium overdoses; no patients required hemodialysis and there were no sequel or deaths. "
06/01/2011 - "Hemodialysis may be considered in critically ill diphenhydramine overdoses not responsive to conventional supportive care."

03/01/2015 - "Intravenous lipid emulsion (ILE) has been broadly attempted in the resuscitation of neurologic and cardiac toxic drug overdoses, however, the role of ILE in the emergency department is poorly defined. "
06/01/2014 - "Intravenous lipid emulsion (ILE) resuscitation is now frequently being used for severe overdoses due to lipophilic drugs. "
11/01/2012 - "Lipid resuscitation therapy using intravenous lipid emulsion (IVLE) for drug overdoses has gained widespread use. "
01/01/2011 - "Not yet in all overdoses with failed resuscitation."
11/16/2005 - "Resuscitation equipment is on hand in case a client overdoses. "

09/01/2007 - "One of the aims was to investigate drug induced interaction in pharmacotherapy, and another was evaluation of the clinical efficacy of Bayesian analysis in detoxication treatments of overdoses using TDM. "
08/01/2014 - "A policy regarding rapid response to chemotherapy overdoses was developed by the authors in an attempt to minimize morbidity and mortality. "
09/17/2007 - "Less severe toxicity occurs with other combinations, overdoses and even single-drug therapy in susceptible individuals. "
05/01/1997 - "Seven steps for preventing lethal chemotherapy overdoses."
07/01/1996 - "Forty patients (54.8%) experienced drug therapy failure, 24 (32.9%) had an adverse reaction, and 9 (12.3%) had overdoses. "

02/01/1981 - "When overdoses were given, a considerable amount of albumin was eliminated very quickly--especially after i.v. injections with the rapid rise of the plasma level. "
01/01/2011 - "To avoid overdoses maximum recommendation dose (MRD) must not be exceeded and aspiration test always performed prior all LA injections. "
12/28/2010 - "Injectable scavenging nanocarriers have been proposed as detoxifying agents when there are no specific antidotes to treat pharmacological overdoses. "
03/01/2007 - "The majority died due to heroin injections ('overdoses'). "
08/20/2009 - "The most common serious adverse events associated with diacetylmorphine injections were overdoses (in 10 patients) and seizures (in 6 patients). "

10/27/1994 - "To prove the clinical relevance of these differences in excretion, patient samples were assigned to 5 categories according to clinical and histopathological criteria: group I--acute steroid-resistant rejection (n = 10); group II--acute steroid-sensitive rejection (n = 10); group III--chronic rejection (n = 23); group IV--stable graft function (n = 27); and group V--miscellaneous disorders (n = 10), including infections, CsA overdoses, and glomerulonephritis. "
08/01/1999 - "The aims of this study were to assess the frequency of attendance at the Austin and Repatriation Medical Centre for paracetamol overdose, the frequency of referral to the Victorian liver transplant unit after serious overdoses, the morbidity and mortality rates in all patients treated and the appropriateness of treatment. "
09/01/1988 - "The overall operative and postoperative mortality, in most cases attributable to overdoses of anesthetic drugs, was 3.8 per cent (114/3031) and the overall graft failure rate, in most instances due to incorrect covering of the grafts, infection or inside-out-grafting, was 1.2 per cent (36/2979)."
05/19/2001 - "Mortality from paracetamol or salicylate overdose; numbers of patients referred to liver units or listed for liver transplant; numbers of transplantations; numbers of overdoses and tablets taken; blood concentrations of the drugs; prothrombin times; sales to pharmacies and other outlets of paracetamol and salicylates. "