Maxillary Sinusitis

Inflammation of the NASAL MUCOSA in the MAXILLARY SINUS. In many cases, it is caused by an infection of the bacteria HAEMOPHILUS INFLUENZAE; STREPTOCOCCUS PNEUMONIAE; or STAPHYLOCOCCUS AUREUS.

Also Known As:

Networked: 633 relevant articles (56 outcomes, 101 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Bronchitis
2.	Infections
3.	Pneumonia (Pneumonitis)
4.	Sinusitis
5.	Pain (Aches)

Experts

1.	Brook, Itzhak: 8 articles (08/2008 - 02/2004)
2.	Mäkelä, Marjukka: 5 articles (10/2015 - 06/2003)
3.	Hausfeld, Jeffrey N: 5 articles (08/2008 - 11/2005)
4.	Rautakorpi, Ulla-Maija: 4 articles (10/2015 - 04/2007)
5.	Jones, Ronald N: 4 articles (05/2008 - 11/2003)
6.	Varonen, Helena: 4 articles (04/2008 - 06/2003)
7.	Gehanno, P: 4 articles (10/2004 - 09/2000)
8.	Zhang, J: 3 articles (11/2016 - 12/2000)
9.	Kim, Su-Gwan: 3 articles (06/2016 - 04/2010)
10.	Kim, Young-Kyun: 3 articles (06/2016 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Maxillary Sinusitis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/1997 - "The aims of this study were to assess which antibiotic is most effective in the treatment of acute maxillary sinusitis in otherwise healthy adults and adolescents, and which has the fewest side effects. " 05/01/1995 - "Natural ostiotomy was as effective against acute maxillary sinusitis as the systemic administration of antibiotics. " 06/01/2003 - "Are antibiotics helpful for acute maxillary sinusitis?" 02/11/2014 - "Randomised controlled trials (RCTs) comparing antibiotics with placebo or antibiotics from different classes for acute maxillary sinusitis in adults. " 04/16/2008 - "Randomized controlled trials (RCTs) comparing antibiotics with placebo or antibiotics from different classes for acute maxillary sinusitis in adults. "
2.	Amoxicillin (Wymox)FDA LinkGeneric 07/01/1997 - "Is amoxicillin beneficial in acute maxillary sinusitis?" 09/01/1988 - "In the present study 141 children aged between 3 and 10 years and suffering from chronic maxillary sinusitis were treated non-selectively in one of 4 ways: amoxicillin combined with decongestive nose drops, drainage of the maxillary sinus, a combination of the two, or a placebo. " 11/01/2005 - "This generated the recommendation that the adult dose of amoxicillin for the treatment of acute maxillary sinusitis (AMS) be increased from 1.5 g/day to 4.0 g/day. " 03/08/1997 - "We used a randomised, placebo-controlled design to test the hypothesis that there would be an improvement associated with amoxycillin treatment for acute maxillary sinusitis patients presenting to general practice. " 02/01/2004 - "influenzae from the nasopharynx of children who had maxillary sinusitis that recurred after amoxicillin therapy than those with AMS."
3.	Clarithromycin (Biaxin)FDA LinkGeneric 12/01/2000 - "Although the efficacy of the 2 formulations was comparable, once-daily clarithromycin extended-release was better tolerated than the twice-daily immediate-release formulation by patients with acute maxillary sinusitis." 12/01/2000 - "This study compares the efficacy and tolerability of extended-release and immediate-release formulations of clarithromycin in patients with acute maxillary sinusitis. " 01/01/2003 - "In patients with acute maxillary sinusitis, a 14-day course of either once-daily clarithromycin extended-release or twice-daily clarithromycin immediate-release produced statistically equivalent clinical cure rates of 85% and 79%, respectively. " 12/01/2000 - "Phase III, randomized, double-blind study of clarithromycin extended-release and immediate-release formulations in the treatment of adult patients with acute maxillary sinusitis." 08/01/1993 - "Clarithromycin twice daily is effective and well tolerated in patients with acute maxillary sinusitis."
4.	telithromycin (Ketek)FDA Link 03/01/2005 - "In a pooled analysis of three large controlled clinical trials involving patients with acute maxillary sinusitis, the bacteriological efficacy of 5- or 10-day treatment with telithromycin and 10-day treatment with comparators was evaluated. " 04/01/2005 - "Clinical and bacteriological efficacy of 5-day telithromycin in acute maxillary sinusitis: a pooled analysis." 04/01/2005 - "The aim of this study was to evaluate the efficacy and tolerance of 5 days of telithromycin (800 mg once a day) in the treatment of bacteriologically proven acute maxillary sinusitis (AMS). " 04/01/2005 - "[Efficacy and safety of telithromycin in the treatment of acute maxillary sinusitis]." 05/01/2002 - "The efficacy and tolerability of oral telithromycin 800 mg once daily for 5 vs. 10 days were assessed in patients with acute maxillary sinusitis (AMS). "
5.	cefuroxime axetil (Ceftin)FDA LinkGeneric 12/01/1989 - "Cefuroxime axetil was an effective therapy for the treatment of acute bacterial maxillary sinusitis in adults." 07/01/2004 - "A 4-day course with pristinamycin 1 g bid is as effective as a 5-day course of cefuroxime axetil 250 mg bid in the treatment of acute maxillary sinusitis in adults." 11/01/2003 - "A comparison of the efficacy of telithromycin versus cefuroxime axetil in the treatment of acute bacterial maxillary sinusitis." 07/01/2004 - "The aim of this multicentric, randomized, double blind study was to demonstrate that a 4-day treatment with pristinamycin 1 g bid was as efficient as a 5-day treatment with cefuroxime axetil 250 mg bid in adults presenting with an acute maxillary sinusitis. " 07/01/2004 - "[Efficiency of a four-day course of pristinamycin compared to a five-day course of cefuroxime axetil for acute bacterial maxillary sinusitis in adult outpatients]."
6.	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 08/01/1998 - "To compare the safety and efficacy of a combination of amoxicillin and clavulanate potassium given orally every 12 hours (amoxicillin, 875 mg; clavulanate, 125 mg) with that given every 8 hours (amoxicillin, 500 mg; clavulanate, 125 mg) for the treatment of patients with acute bacterial maxillary sinusitis. " 08/01/1998 - "Amoxicillin and clavulanate given every 12 hours is as effective and as safe as administration every 8 hours for the treatment of acute bacterial maxillary sinusitis." 08/01/1998 - "A combination of amoxicillin and clavulanate every 12 hours vs every 8 hours for treatment of acute bacterial maxillary sinusitis." 09/01/1992 - "Our results indicate that cefuroxime axetil twice a day is as effective as amoxicillin/clavulanate three times a day in the treatment of acute bacterial maxillary sinusitis but produces fewer adverse effects." 12/01/1993 - "Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis."
7.	Levofloxacin (Levaquin)FDA Link 01/01/2003 - "[Efficacy of the drug tavanik (levofloxacin) in acute and maxillary sinusitis]." 05/01/2008 - "Eighteen patients with a radiologically confirmed acute maxillary sinusitis were enrolled into a study evaluating the relationship between levofloxacin exposure and the time course of antimicrobial effect using SSAS. " 05/01/2008 - "Commentary on "Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis" by Ambrose et al." 05/01/2008 - "Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis." 01/01/2007 - "Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis."
8.	Penicillin V (Phenoxymethylpenicillin)FDA LinkGeneric 10/02/2000 - "The aim of the study was to compare the effectiveness of penicillin V with placebo in the treatment of adult patients with acute maxillary sinusitis (in general practice). " 03/01/2000 - "Randomised, double blind, placebo controlled trial of penicillin V in the treatment of acute maxillary sinusitis in adults in general practice." 03/01/2000 - "To compare the effectiveness of penicillin V with placebo in the treatment of adult patients with acute maxillary sinusitis in general practice. " 10/02/2000 - "Penicillin V is more effective than placebo in the treatment of acute maxillary sinusitis in adults in general practice, but only in patients with pronounced pain." 03/01/2000 - "Penicillin V is more effective than placebo in the treatment of acute maxillary sinusitis in adults in general practice, but only in patients with pronounced pain."
9.	AntralIBA 12/01/2009 - "26 patients recovered completely; one patient underwent re-intervention with FESS and an intraoral approach 2 years after implant removal, due to persistent signs and symptoms of maxillary sinusitis and oro-antral communication. " 12/06/2022 - "The incidence of maxillary sinusitis and oro-antral communications was found to be less likely in "recent" vs "less recent" studies (p<0.05). " 10/01/2012 - "The aim of this study was to analyse the frequency of maxillary sinusitis and oro-antral fistulae in BRONJ of the maxilla. " 06/01/2004 - "Bacteriologic study of the antral washings / aspirates should be done in every patient with chronic maxillary sinusitis. " 01/01/2000 - "The objective of this study was to examine different plain radiographic features and correlate them with antral lavage results in patients suffering from chronic maxillary sinusitis. "
10.	Nasal Decongestants (Decongestants)IBA 03/01/1995 - "Clinical signs and symptoms most helpful in the diagnosis of maxillary sinusitis are the presence of a maxillary toothache, lack of improvement with decongestants, a purulent nasal discharge, cough, purulent secretions observed on nasal examination, abnormal transillumination, and sinus tenderness. " 09/01/1996 - "We conclude that decongestant-antihistamine need not be given to the child with acute maxillary sinusitis." 04/01/2006 - "We investigated the efficacy of locally applied nasal decongestant agents and corticosteroids for preventing nosocomial maxillary sinusitis in mechanically ventilated patients with multiple trauma. " 11/01/1992 - "Logistic regression analysis showed five independent predictors of sinusitis: maxillary toothache (odds ratio, 2.9), transillumination (odds ratio, 2.7), poor response to nasal decongestants or antihistamines (odds ratio, 2.4), colored nasal discharge reported by the patient (odds ratio, 2.2), or mucopurulence seen during examination (odds ratio, 2.9). " 05/01/1975 - "Six groups, each containing 50 patients with acute maxillary sinusitis, were treated with ampicillin plus nasal decongestant, ampicillin plus irrigation, cephradine plus nasal decongestant, cephradine plus irrigation, erythromycinestolate plus nasal decongestant, erythromycinestolate plus irrigation. "

Therapies and Procedures

1.	Therapeutics 03/01/1989 - "Thus, antimicrobial therapy which is effective against Haemophilus influenzae seems indicated in most cases of non-purulent maxillary sinusitis." 06/01/2021 - "For recalcitrant chronic maxillary sinusitis, modified endoscopic medial maxillectomy has been shown to be clinically beneficial after failed maxillary antrostomy as endoscopic medial maxillectomy may offer improved topical therapy delivery. " 09/01/1986 - "In 198 patients (244 sinuses) with chronic maxillary sinusitis of either rhinogenous or dental etiology all patients were judged as cured or improved at the short-term control 1-3 months after completion of therapy. " 11/01/1996 - "This study illustrates the microbial dynamics of maxillary sinusitis that did not respond to antimicrobial therapy." 01/01/2013 - "Postoperative maxillary sinusitis decreased the survival rates of implants, whereas early diagnosis and combined medical and surgical therapy had the opposite effect."
2.	Laser Therapy (Surgery, Laser) 07/17/2020 - "Using high intensity intra-oral laser therapy with medical treatment is more effective than using medical treatment only for treatment of chronic maxillary sinusitis." 05/01/1991 - "In terms of circulation changes, laser therapy was more beneficial in the case of acute maxillary sinusitis. " 07/01/2002 - "Efficacy of prescribed noninvasive & invasive types of treatment of maxillary sinusitis has been compared with low-dose LASER therapy (LLT). " 03/01/1994 - "[The clinico-immunological assessment of the efficacy of magnetic-laser therapy in patients with chronic maxillary sinusitis]." 03/01/1994 - "Magneto-laser therapy (80 Hz, 0.01 mW/cm2, 12 min) consisting of 10 sessions was performed in patients with maxillary sinusitis (MS). "
3.	Punctures 01/01/2003 - "Halotherapy was found effective in the treatment of acute purulent maxillary sinusitis without puncture." 03/01/2005 - "Maxillary sinus puncture is considered the gold standard for diagnosing acute bacterial maxillary sinusitis (ABMS) and for identifying bacterial pathogens in antimicrobial trials of ABMS. " 12/01/2002 - "The study was performed prospectively on 40 adult patients with acute maxillary sinusitis diagnosed by sinus puncture. " 03/01/2000 - "Thirteen patients with maxillary sinusitis in one or both sinuses underwent endoscopically guided culture of the middle meatus and maxillary sinus puncture with aspiration and culture (16 total study samples). " 01/01/2023 - "[Dynamic indicators of the use of puncture method for the treatment of acute maxillary sinusitis in healthcare institutions of the city of Moscow]."
4.	Curettage 01/01/1954 - "[Two cases of endonasal trepanation of the chronic maxillary sinusitis without curettage of granulations]." 04/01/2010 - "The symptoms of maxillary sinusitis were improved by curettage through the lateral wall of the maxillary sinus, antibiotics, and sinus irrigation after 2 weeks of the operation. "
5.	Mechanical Ventilators (Ventilator) 11/01/2000 - "The efficacy of systemic antibiotics on the treatment of ventilator-associated infectious maxillary sinusitis (VAIMS) is debated. "