Isotretinoin (Accutane)

10/01/2015 - "Isotretinoin is known to be the most effective treatment of severe and persistent acne. "
07/01/2015 - "Isotretinoin is the strongest, most effective oral treatment for patients with severe acne vulgaris, with remission rates of 89% and higher. "
01/01/2014 - "In the 1970s, the onset of isotretinoin dramatically improved acne management. "
12/01/2013 - "Isotretinoin is the most effective treatment for acne. "
04/01/2013 - "Isotretinoin has been the most effective and long-lasting drug for the treatment of severe acne for more than 30 years and can achieve long-term remission in 70-80 % of patients after a single course. "

05/01/2002 - "To estimate the efficacy of isotretinoin for prevention of progression of low-grade squamous intraepithelial lesions (SIL) of the cervix to high-grade lesions or invasive cervical cancer; to estimate the regression rate of low-grade SIL with isotretinoin and the toxicity of isotretinoin in this setting; and to correlate serum CD4 levels with progression of low-grade SIL. "
02/01/2013 - "In 1999, the results of a Children's Cancer Group trial established that consolidation therapy after induction, surgery, and radiation should include purged autologous stem cell rescue followed by maintenance with isotretinoin. "
01/01/2008 - "Our studies using animal model reveled that 13-cis-retinoic acid could significantly (p < 0.001) inhibit the tumor directed capillaries. "
08/01/2007 - "Combination of two differentiation agents such as phenylbutyrate (PB) and 13-cis-retinoic acid (CRA) has been shown to have an additive inhibitory effect on tumor growth in preclinical studies. "
04/05/2006 - "We conducted a phase III randomized trial of low-dose isotretinoin versus placebo in early-stage HNSCC patients to assess its effect on second primary tumor incidence and survival. "

12/01/1986 - "At the end of the study period, isotretinoin was found to be highly effective in the clearing of refractory rosacea lesions."
03/05/1982 - "13-cis-retinoic acid was given with good results to 7 patients with exceptionally severe rosacea. "
11/01/2011 - "Systemic isotretinoin has been known for decades as an effective and safe therapeutic option in the treatment of severe and refractory forms of rosacea. "
07/01/2010 - "Systemic isotretinoin has been known for decades to be effective in the treatment of severe forms of rosacea, but it must be used off-label because of the lack of evidence-based data. "
12/01/2009 - "Oral isotretinoin may be effective for phymatous rosacea and treatment resistant rosacea. "

11/01/2001 - "Because of the clinical and therapeutic implications (impaired quality of life, pigmentation or scarring and remarkable efficacy of oral isotretinoin) this clinical picture merits more attention, and the modalities for the prescription of isotretinoin in this context should be defined."
11/01/1990 - "Once conventional therapies failed to result in a response, the eruption cleared, leaving pitted, atrophic scarring after a twenty week course of isotretinoin treatment."
10/01/2014 - "It is reported that patients on oral isotretinoin have greater risk of developing scars and delayed wound healing with invasive procedures. "
01/01/2014 - "Even though the combination of systemic isotretinoin and medium to deep CP has been associated with serious side effects such as delayed wound healing and enlarged incidence of scarring, to date superficial CP and concomitant systemic isotretinoin have been considered safe. "
09/01/2012 - "Exaggerated cicatrization related to oral isotretinoin was reported in the 1980s and 1990s. "

12/01/2014 - "This study was planned to compare the efficacy of oral PUVAsol with that of the combination of oral isotretinoin and PUVAsol in patients with chronic plaque psoriasis. "
12/01/2014 - "Clinical efficacy of psoralen + sunlight vs. combination of isotretinoin and psoralen + sunlight for the treatment of chronic plaque-type psoriasis vulgaris: a randomized hospital-based study."
06/01/2011 - "A single blind randomized clinical study: the efficacy of isotretinoin plus narrow band ultraviolet B in the treatment of psoriasis vulgaris."
08/01/2006 - "During the study period 1419 subjects were exposed to Isotretinoin and 1102 suffered from psoriasis. "
01/15/2015 - "Conclusively, an efficacious and stable nail lacquer of isotretinoin was developed for potential clinical topical use to target the drug to nail bed in treatment of nail psoriasis. "