Chronic Neutrophilic Leukemia

A rare myeloproliferative disorder that is characterized by a sustained, mature neutrophilic leukocytosis. No monocytosis, EOSINOPHILIA, or basophilia is present, nor is there a PHILADELPHIA CHROMOSOME or bcr-abl fusion gene (GENES, ABL).

Also Known As:

Networked: 91 relevant articles (5 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	BCR-ABL Negative Atypical Chronic Myeloid Leukemia (Leukemia, Myeloid, Philadelphia Negative)
2.	Primary Myelofibrosis (Myelosclerosis)
3.	Multiple Myeloma
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
5.	Neoplasms (Cancer)

Experts

1.	Maxson, Julia E: 9 articles (11/2022 - 09/2013)
2.	Tyner, Jeffrey W: 8 articles (01/2020 - 09/2013)
3.	Tefferi, Ayalew: 6 articles (01/2021 - 08/2005)
4.	Druker, Brian J: 4 articles (11/2022 - 01/2014)
5.	Press, Richard D: 4 articles (01/2020 - 01/2014)
6.	Dao, Kim-Hien T: 3 articles (01/2020 - 01/2014)
7.	Gotlib, Jason: 3 articles (01/2020 - 09/2013)
8.	Elliott, Michelle A: 3 articles (07/2015 - 05/2004)
9.	Pardanani, Animesh: 3 articles (07/2015 - 04/2006)
10.	Oh, Stephen T: 2 articles (01/2020 - 12/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Neutrophilic Leukemia:

1.	ruxolitinibIBA 02/01/2021 - "Durable remission with ruxolitinib in a chronic neutrophilic leukemia patient harboring a truncation and membrane proximal CSF3R compound mutation." 02/23/2020 - "[Ruxolitinib in the treatment of two cases of chronic neutrophilic leukemia]." 01/01/2019 - "Ruxolitinib appears promising also in chronic neutrophilic leukemia, where mutations in CSF3R are common. " 12/14/2018 - "[Ruxolitinib for chronic neutrophilic leukemia: a case report and literature review]." 01/01/2017 - "Ruxolitinib, a potent JAK1/JAK2 inhibitor, induces temporary reductions in the allelic burden of concurrent CSF3R mutations in chronic neutrophilic leukemia."
2.	Hydroxyurea (Hydrea)FDA LinkGeneric 11/01/1994 - "[A case of chronic neutrophilic leukemia accompanied with severe bone marrow fibrosis which was effectively treated by hydroxyurea]." 01/01/2014 - "Treatment of coexisting chronic neutrophilic leukemia and light chain multiple myeloma with hydroxyurea, bortezomib, and dexamethasone." 05/01/2015 - "The current study presents the case of a 78-year-old male with concurrent chronic neutrophilic leukemia (CNL) and multiple myeloma (MM) who developed acute myeloid leukemia after two years of treatment with hydroxyurea, cyclophosphamide, prednisone and thalidomide. "
3.	Imatinib Mesylate (Gleevec)FDA Link 12/01/2004 - "Efficacy of imatinib mesylate (STI571) in chronic neutrophilic leukemia with t(15;19): case report." 11/07/2013 - "Imatinib therapy in a patient with suspected chronic neutrophilic leukemia and FIP1L1-PDGFRA rearrangement."
4.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 08/01/1996 - "It is clearly demonstrated that serum G-CSF levels of the patients with PMF and chronic neutrophilic leukemia (CNL) are extremely low, similar to those in patients with CML in CP in this study. " 01/01/2023 - "There have been a few cases of G-CSF -producing myeloma reported, and it has previously been reported as chronic neutrophilic leukemia with M proteinemia. " 02/01/2016 - "chronic neutrophilic leukemia) are related to the presence of various CSF3R mutations, which leads to abnormal G-CSF signal pathways. " 03/01/2004 - "[Granulocyte-colony stimulating factor-producing myeloma with clinical manifestations mimicking chronic neutrophilic leukemia]." 02/01/2003 - "Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia."
5.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/01/2022 - "A case of chronic neutrophilic leukemia and multiple myeloma showing the benefits of lenalidomide and cyclophosphamide therapy in treating both conditions." 05/01/2015 - "The current study presents the case of a 78-year-old male with concurrent chronic neutrophilic leukemia (CNL) and multiple myeloma (MM) who developed acute myeloid leukemia after two years of treatment with hydroxyurea, cyclophosphamide, prednisone and thalidomide. "
6.	Janus Kinase InhibitorsIBA 12/01/2014 - "We also discuss the role of JAK inhibitors for treatment of CSF3RT618I-mutated chronic neutrophilic leukemia and hematologic malignancies with rearranged JAK2 gene." 06/01/2014 - "Chronic neutrophilic leukemia with concurrent CSF3R and SETBP1 mutations: single colony clonality studies, in vitro sensitivity to JAK inhibitors and lack of treatment response to ruxolitinib."
7.	Thalidomide (Thalomid)FDA Link 05/01/2015 - "The current study presents the case of a 78-year-old male with concurrent chronic neutrophilic leukemia (CNL) and multiple myeloma (MM) who developed acute myeloid leukemia after two years of treatment with hydroxyurea, cyclophosphamide, prednisone and thalidomide. "
8.	Prednisone (Sone)FDA LinkGeneric 05/01/2015 - "The current study presents the case of a 78-year-old male with concurrent chronic neutrophilic leukemia (CNL) and multiple myeloma (MM) who developed acute myeloid leukemia after two years of treatment with hydroxyurea, cyclophosphamide, prednisone and thalidomide. "
9.	Colony-Stimulating Factors (Colony Stimulating Factor)IBA 07/01/2023 - "A novel colony stimulating factor 3 receptor activating mutation identified in a patient with chronic neutrophilic leukemia." 11/01/2022 - "Colony stimulating factor 3 receptor (CSF3R) mutations lead to JAK pathway activation and are the molecular hallmark of chronic neutrophilic leukemia (CNL). " 01/01/2020 - "Activating mutations in the membrane-proximal region of the colony-stimulating factor 3 receptor (CSF3R) are a hallmark of chronic neutrophilic leukemia (CNL) with the T618I mutation being most common. " 09/18/2018 - "Colony-stimulating Factor 3 Receptor Mutated Chronic Neutrophilic Leukemia: A Rare Case Report." 07/01/2015 - "Colony stimulating factor 3 receptor gene (CSF3R) mutations have recently been associated with chronic neutrophilic leukemia (CNL). "
10.	Alkaline PhosphataseIBA 01/01/2020 - "Leukocyte alkaline phosphatase score frequently aids in diagnosis but may or may not be contributory, especially in differentiating chronic neutrophilic leukemia. " 09/01/1992 - "A high neutrophil alkaline phosphatase score and a normal bone marrow cell karyotype suggested that the patient had chronic neutrophilic leukemia rather than chronic myeloid leukemia. " 01/01/2013 - "Chronic neutrophilic leukemia (CNL) is a rare type of leukemia characterized by a proliferation mainly of mature neutrophils, elevated neutrophil-alkaline phosphatase activity, and no presence of the Philadelphia chromosome. " 12/01/2004 - "Chronic Neutrophilic Leukemia (CNL) is a rare myeloproliferative disorder characterized by a persistent increase of mature peripheral neutrophils, myeloid hyperplasia in bone marrow, hepatosplenomegaly, elevated neutrophil alkaline phosphatase (NAP) and absence of Philadelphia chromosome, with no evidence of infection or malignancy sufficient to mimic a leukemoid reaction. " 02/01/1987 - "Chronic neutrophilic leukemia, which may be regarded a variant of myeloproliferative disease, is associated with mature peripheral neutrophilia, hepatosplenomegaly, tissue infiltration by mature and immature granulocytes, an elevated leucocyte alkaline phosphatase score, absence of the Ph1 chromosome and elevated vitamin B12. "

Therapies and Procedures

1.	Hematopoietic Stem Cell Transplantation 01/01/2018 - "Chronic neutrophilic leukemia, an extremely rare cause of neutrophilia in childhood: Cure with hematopoietic stem cell transplantation."
2.	Therapeutics 12/01/2004 - "Chronic neutrophilic leukemia (CNL) is a rare hematologic disorder, for which there is no standard therapy. " 08/01/1993 - "Successful alpha-2b-interferon therapy for chronic neutrophilic leukemia." 08/01/2009 - "Cases included predominantly rare entities like chronic eosinophilic leukemia and related disorders, chronic neutrophilic leukemia, and others with specific genetic abnormalities that allowed molecularly targeted therapy. " 01/01/2020 - "Insights on mechanisms of clonal evolution in chronic neutrophilic leukemia on ruxolitinib therapy." 11/07/2013 - "Imatinib therapy in a patient with suspected chronic neutrophilic leukemia and FIP1L1-PDGFRA rearrangement."
3.	Stem Cell Transplantation 01/01/2023 - "Successful Allogeneic Stem Cell Transplantation with Ruxolitinib Maintenance Therapy for CSF3R T618I Mutant Chronic Neutrophilic Leukemia" 05/01/2015 - "T618I-Mutated Colony Stimulating Factor 3 Receptor in Chronic Neutrophilic Leukemia and Chronic Myelomonocytic Leukemia Patients who Underwent Allogeneic Stem Cell Transplantation."
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/01/2009 - "Chronic neutrophilic leukemia with congenital Robertsonian translocation successfully treated with allogeneic bone marrow transplantation in a young man." 05/01/2007 - "Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation."
5.	Induction Chemotherapy 09/01/2019 - "Molecular response of CSF3R T618I harboring chronic neutrophilic leukemia after induction chemotherapy linked to cord blood transplantation."