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BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)

Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Also Known As:
Chronic Myelogenous Leukemia; Chronic Myeloid Leukemia; Leukemia, Chronic Myelogenous; Leukemia, Chronic Myeloid; Leukemia, Myeloid, Philadelphia Positive; Chronic Granulocytic Leukemia; Myeloid Leukemia, Chronic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelogenous, Ph1 Positive; Leukemia, Myelogenous, Ph1-Positive; Leukemia, Myeloid, Ph1 Positive; Leukemia, Myeloid, Ph1-Positive; Leukemia, Myeloid, Philadelphia-Positive; Myelogenous Leukemia, Ph1-Positive; Myeloid Leukemia, Ph1-Positive; Myeloid Leukemia, Philadelphia-Positive; Chronic Granulocytic Leukemias; Chronic Myelocytic Leukemia; Chronic Myelocytic Leukemias; Chronic Myelogenous Leukemias; Chronic Myeloid Leukemias; Granulocytic Leukemias, Chronic; Leukemia, Chronic Granulocytic; Leukemia, Chronic Myelocytic; Leukemia, Ph1-Positive Myelogenous; Leukemia, Ph1-Positive Myeloid; Leukemia, Philadelphia-Positive Myeloid; Leukemias, Chronic Granulocytic; Leukemias, Chronic Myelocytic; Leukemias, Chronic Myelogenous; Leukemias, Chronic Myeloid; Leukemias, Ph1-Positive Myelogenous; Leukemias, Ph1-Positive Myeloid; Leukemias, Philadelphia-Positive Myeloid; Myelocytic Leukemias, Chronic; Myelogenous Leukemia, Ph1 Positive; Myelogenous Leukemias, Chronic; Myelogenous Leukemias, Ph1-Positive; Myeloid Leukemia, Ph1 Positive; Myeloid Leukemia, Philadelphia Positive; Myeloid Leukemias, Chronic; Myeloid Leukemias, Ph1-Positive; Myeloid Leukemias, Philadelphia-Positive; Ph1-Positive Myelogenous Leukemia; Ph1-Positive Myelogenous Leukemias; Ph1-Positive Myeloid Leukemia; Ph1-Positive Myeloid Leukemias; Philadelphia-Positive Myeloid Leukemia; Philadelphia-Positive Myeloid Leukemias; Granulocytic Leukemia, Chronic; Leukemia, Granulocytic, Chronic; Leukemia, Myelocytic, Chronic; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Chronic; Myelocytic Leukemia, Chronic; Myelogenous Leukemia, Chronic
Networked: 14683 relevant articles (1428 outcomes, 1537 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Leukemia
2. Philadelphia Chromosome
3. Blast Crisis (Blast Phase)
4. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
5. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)

Experts

1. Cortes, Jorge: 266 articles (11/2022 - 03/2002)
2. Kantarjian, Hagop: 211 articles (09/2022 - 01/2000)
3. Hochhaus, Andreas: 169 articles (01/2022 - 01/2002)
4. Breccia, Massimo: 156 articles (11/2022 - 04/2004)
5. Saglio, Giuseppe: 142 articles (10/2022 - 02/2002)
6. Kantarjian, Hagop M: 136 articles (01/2022 - 03/2002)
7. Baccarani, Michele: 132 articles (11/2022 - 02/2002)
8. O'Brien, Susan: 123 articles (01/2020 - 03/2002)
9. Cortes, Jorge E: 121 articles (11/2022 - 07/2002)
10. Jabbour, Elias: 115 articles (11/2022 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to BCR-ABL Positive Chronic Myelogenous Leukemia:
1. Imatinib Mesylate (Gleevec)FDA Link
2. Tyrosine Kinase InhibitorsIBA
3. Dasatinib (BMS 354825)FDA Link
4. nilotinibFDA Link
5. Interferon-alpha (Interferon Alfa)IBA
6. bcr-abl Fusion ProteinsIBA
7. Phosphotransferases (Kinase)IBA
8. InterferonsIBA
9. Pharmaceutical PreparationsIBA
10. Busulfan (Busulfex)FDA Link

Therapies and Procedures

1. Therapeutics
2. Bone Marrow Transplantation (Transplantation, Bone Marrow)
3. Drug Therapy (Chemotherapy)
4. Stem Cell Transplantation
5. Hematopoietic Stem Cell Transplantation