Prolymphocytic Leukemia

A chronic leukemia characterized by a large number of circulating prolymphocytes. It can arise spontaneously or as a consequence of transformation of CHRONIC LYMPHOCYTIC LEUKEMIA.
Also Known As:
Leukemia, Prolymphocytic; Leukemias, Prolymphocytic; Prolymphocytic Leukemias
Networked: 148 relevant articles (14 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
2. Leukemia
3. Non-Hodgkin Lymphoma (Lymphosarcoma)
4. Hairy Cell Leukemia
5. Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)


1. Keating, Michael J: 4 articles (01/2003 - 02/2002)
2. O'Brien, Susan: 3 articles (02/2005 - 02/2002)
3. Blaise, Didier: 2 articles (08/2015 - 03/2015)
4. Cornillon, Jérôme: 2 articles (08/2015 - 03/2015)
5. Deconinck, Eric: 2 articles (08/2015 - 03/2015)
6. Larson, Richard A: 2 articles (05/2015 - 02/2013)
7. Kipps, Thomas J: 2 articles (05/2015 - 01/2003)
8. Ando, Kiyoshi: 2 articles (12/2014 - 07/2005)
9. Rai, Kanti R: 2 articles (02/2013 - 01/2003)
10. Ravandi, Farhad: 2 articles (11/2006 - 02/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Prolymphocytic Leukemia:
1. fludarabineIBA
2. alemtuzumab (Campath)FDA Link
3. rituximab (Mabthera)FDA Link
4. Cyclophosphamide (Cytoxan)FDA LinkGeneric
5. Pentostatin (Nipent)FDA LinkGeneric
6. Monoclonal AntibodiesIBA
02/01/2004 - "In recent years preclinical and clinical studies have been undertaken with selected monoclonal antibodies (MoAbs) either alone or coniugated to toxins in patients with several lymphoid malignancies, including chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PLL) and hairy cell leukemia (HCL). "
10/01/1989 - "The antigenic profile and the proliferative pathways in leukemic cells from the patient TRT with T-prolymphocytic leukemia (T-PLL) were analyzed using monoclonal antibodies (MoAbs) and cytokines. "
01/01/1990 - "The neoplastic lymphoid cells in 33 patients with chronic lymphocytic leukemia (CLL), 1 case of prolymphocytic leukemia (PLL), and 29 patients with various types of non-Hodgkin's lymphoma (NHL) were examined for the expression of transferrin receptors (TR) using a panel of three anti-TR monoclonal antibodies (MAb). "
04/01/2005 - "Four kinds of immunotherapy for acute leukemia are under investigation: (1) monoclonal antibodies, among them, Mylotarg (cytotoxic antibiotic calicheamicin linked to CD33 Mab) is given for the treatment of refractory or relapsed acute myeloid leukemia and molecular relapse in acute promyelocytic leukemia with good results, Campath-1H (antiCD52 Mab) is administered in the treatment of prolymphocytic leukemia and Rituximab (anti-CD20 Mab) in B-PLL with high complete remission rates. "
07/01/1990 - "Peripheral blood mononuclear cells from 24 patients with prolymphocytic leukemia (PLL) were isolated using a Ficoll-Hypaque gradient and stained by indirect immunofluorescence using a wide panel of monoclonal antibodies against B cell restricted and associated antigens, including HLA DR (Ia), CD19, CD21 (C3dR) surface membrane immunoglobulin (Slg), CD10 (CALLA), C3b, B5, CD25 (TAC), PCA1, T9, and T10. "
7. Cytarabine (Cytosar-U)FDA LinkGeneric
8. Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
9. Cisplatin (Platino)FDA LinkGeneric
10. Immunoglobulins (Immunoglobulin)IBA

Therapies and Procedures

1. Radiotherapy
2. Stem Cell Transplantation
3. Immunotherapy
4. Transplantation (Transplant Recipients)
5. Salvage Therapy