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T-Cell Leukemia (Leukemia, T Cell)

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A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.

Also Known As:

Leukemia, T Cell; Leukemia, T-Cell; Leukemia, Lymphocytic, T Cell; T Lymphocytic Leukemia; Leukemia, T Lymphocytic; Leukemia, T-Cell Lymphocytic; Leukemia, T-Lymphocytic; Leukemias, T Lymphocytic; Leukemias, T-Cell; Leukemias, T-Cell Lymphocytic; Leukemias, T-Lymphocytic; Lymphocytic Leukemia, T; Lymphocytic Leukemia, T Cell; Lymphocytic Leukemias, T; Lymphocytic Leukemias, T-Cell; T Cell Leukemia; T Lymphocytic Leukemias; T-Cell Leukemias; T-Cell Lymphocytic Leukemia; T-Cell Lymphocytic Leukemias; T-Lymphocytic Leukemias; Leukemia, Lymphocytic, T-Cell; Lymphocytic Leukemia, T-Cell; T-Lymphocytic Leukemia

Networked: 2153 relevant articles (32 outcomes, 131 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
2.	Infection
3.	Spinal Cord Diseases
4.	Arthritis (Polyarthritis)
5.	Lymphoma (Lymphomas)

Experts

1.	Tanaka, Yuetsu: 36 articles (12/2014 - 05/2002)
2.	Mori, Naoki: 22 articles (10/2013 - 02/2002)
3.	Fujii, Masahiro: 18 articles (09/2015 - 03/2002)
4.	Mesnard, Jean-Michel: 15 articles (06/2015 - 12/2002)
5.	Mahieux, Renaud: 14 articles (08/2015 - 09/2002)
6.	Tomita, Mariko: 14 articles (01/2012 - 09/2004)
7.	Ciminale, Vincenzo: 13 articles (01/2015 - 02/2002)
8.	Higuchi, Masaya: 13 articles (12/2014 - 03/2002)
9.	Jeang, Kuan-Teh: 13 articles (11/2011 - 05/2002)
10.	Utsunomiya, Atae: 12 articles (11/2015 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to T-Cell Leukemia:

1.	DNA (Deoxyribonucleic Acid)IBA 11/01/2015 - "Quantitative PCR (qPCR) analysis of human T-cell leukemia virus type 1 (HTLV-1) was used to assess the amount of HTLV-1 provirus DNA integrated into the genomic DNA of host blood cells. " 03/01/2015 - "A Southern blot analysis of the cervical lymph node biopsy specimen showed a human T-cell leukemia virus type 1 provirus DNA monoclonal band. " 12/16/2014 - "As an illustration, the predicted DNA binding site for the poorly characterized T-cell leukemia homeobox 3 (TLX3) TF was confirmed with gel shift assay experiments. " 05/01/2009 - "Human T-cell leukemia virus type I proviral DNA was detected in the blood and cerebrospinal fluid by Southern blot analysis and polymerase chain reaction assay. " 04/01/2009 - "Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization."
2.	arsenic trioxide (Trisenox)FDA Link 08/01/2007 - "In this study, we demonstrated that arsenic trioxide (As2O3) induced in vitro growth inhibition and/or apoptosis of human T-cell leukemia cell line Molt-4 in a caspase-independent manner. " 10/05/2013 - "Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: focus on PI3K/Akt signaling pathway." 12/15/2001 - "Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage." 05/01/2000 - "Arsenic trioxide and the growth of human T-cell leukemia virus type I infected T-cell lines." 08/01/2007 - "Telomere attrition and chromosome instability via downregulation of TRF2 contributes to arsenic trioxide-induced apoptosis of human T-Cell leukemia cell line molt-4 cells."
3.	Prednisolone (Predate)FDA LinkGeneric 07/01/2001 - "The correlations between MRD and in vitro prednisolone resistance were even more pronounced when B cell precursor and T cell leukemia were analyzed separately (B cell precursor ALL: MRD-PI vs prednisolone LC50: n = 33, rs = 0.47, P = 0.006; T cell ALL: MRD-PI vs prednisolone resistance: n = 8, rs = 0.84, P = 0.009). " 04/01/1990 - "The primary cause of severe myelopathy in this patient may be infection with human T-cell leukemia virus type I rather than with human immunodeficiency virus type 1. Treatment with prednisolone resulted in improvement of the lower-extremity weakness, reduction in flexor spasms, and slower but significant improvement in urinary symptoms. " 10/01/2015 - "Considering that there is no effective treatment for human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis, this study aimed to assess the impact of triple combination therapy-interferon-α, valproic acid, and prednisolone-on clinical outcomes, main HTLV-1 viral factors, and host anti-HTLV-1 antibody response. " 10/01/2015 - "Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis."
4.	nelarabine (506U78)FDA Link 05/20/2005 - "Further studies are planned to determine whether the addition of nelarabine to front-line therapy for T-cell leukemia in children will improve survival." 05/20/2005 - "Nelarabine is active as a single agent in recurrent T-cell leukemia, with a response rate more than 50% in first bone marrow relapse. " 01/01/1999 - "2-amino-9-beta-D-arabinosyl-6-methoxy-9H-guanine (GW506U78), a prodrug of arabinosylguanine (ara-G), is effective in T-cell leukemias. " 12/01/2006 - "We used low dose clofarabine and induced a remission in a patient who relapsed in the skin and marrow after allogeneic transplant and was refractory to nelarabine and report a near complete response, suggesting significant activity for low intermittent dose clofarabine in patients with relapsed T-cell leukemias."
5.	Interleukin-2 (IL2)IBA 01/30/1987 - "In this study we provide evidence that distinct DNA sequences within the 5'-flanking regions of the genes for interleukin-2 (IL-2) and its receptor (IL-2R) are involved in human T-cell-specific activation of transcription by p40x, a product of human T cell leukemia virus type I (HTLV-1). " 05/01/2007 - "In the murine T-cell leukemia CTLL-2 cells, A-FABP-immunoreactivity is also induced in both of the cytoplasm and nucleus when the apoptosis is induced by IL-2 retrieval together with DEX treatment, while in the presence of IL-2 A-FABP-immunoreactivity is confined to the cytoplasm with DEX treatment. " 04/06/2006 - "The transition from interleukin-2 (IL-2)-dependent to IL-2-independent growth is considered one of the key steps in the transformation of human T-cell leukemia virus type-I (HTLV-I)-infected T cells. " 09/01/2005 - "Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus." 01/01/2005 - "PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line."
6.	AntigensIBA 07/01/2005 - "Among various regions analyzed, we found that the addition of a regulatory sequence from the R region of the long terminal repeat from human T-cell leukemia virus type 1 (HTLV-1) to the cytomegalovirus (CMV) enhancer/promoter increased transgene expression 5- to 10-fold and improved cellular immune responses to human immunodeficiency virus type 1 (HIV-1) antigens. " 08/01/2009 - "HBZ is an immunogenic protein, but not a target antigen for human T-cell leukemia virus type 1-specific cytotoxic T lymphocytes." 03/01/2007 - "This report suggests that a subset of CD7+ T-cell leukemias without mature T-cell antigens (CD4-, CD8-) are minimally differentiated and can relapse as AML." 09/01/2006 - "All expressed T-cell leukemia 1 (TCL-1) and CD7; cutaneous lymphocyte antigen expression was discernible in a dot-like perinuclear array. " 01/21/2005 - "Notably, the A6 TCR specific for the immunodominant HLA A2-restricted human T cell leukemia virus type 1 Tax(11-19) epitope bound to HLA A2-HuD(87-95) (K(D) 120 microm by surface plasmon resonance), an epitope implicated as a causal antigen in the paraneoplastic neurological degenerative disorder anti-Hu syndrome. "
7.	Immunotoxins (Immunotoxin)IBA 03/01/2001 - "We used this technique to assess the efficacy of a T cell-specific immunotoxin in a severe combined immunodeficient mouse model of human T-cell leukemia. " 04/01/2002 - "Augmentation of the activity of an immunotoxin, anti-Tac(Fv)-PE40KDEL, in T cell lines infected with human T cell leukemia virus type-I." 05/01/1984 - "An immunotoxin with therapeutic potential in T cell leukemia: WT1-ricin A." 11/01/2004 - "IL-18-PE38 recombinant immunotoxin expression vector will provide the basis for study on the targeted cytotoxic activity to Th1 cell and may have some potential value in the treatment of autoimmune disease and T cell leukemias." 11/02/1985 - "[Autograft of bone marrow treated by immunotoxin T 101 for the treatment of T-cell leukemia and lymphoma. "
8.	tax Gene Products (tax Gene Product)IBA 06/01/2002 - "Recent studies suggest that the human T-cell leukemia virus type 1 (HTLV-1) Tax protein induces oxidative stress and apoptotic T-cell death. " 04/01/1995 - "There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-cell leukemia virus type I (HTLV-I), although the sequence variation between patients is small compared with that of human immunodeficiency virus type 1. In the present study, we investigated whether naturally occurring amino acid substitutions changed the properties of the Tax protein in two respects: first, recognition of the protein by cytotoxic T lymphocytes (CTL), and second, the ability of the Tax protein to transactivate various promoters. " 12/01/1992 - "The present study demonstrates that the tax gene product of human T-cell leukemia virus type I trans activates the major enhancer of HCMV more than 60-fold in the T-cell line Jurkat. " 12/01/2015 - "Here, we show that HIC and I-mfa directly interact with human T-cell leukemia virus type-1 (HTLV-1) Tax protein in vitro. " 09/01/2014 - "Whether NF-κB promoter transactivation by the human T-cell leukemia virus type 1 (HTLV-1) Tax protein requires Tax SUMOylation is still a matter of debate. "
9.	Interleukin-2 Receptors (IL 2 Receptor)IBA 10/01/1988 - "In the present study, we describe a case of chronic T-lymphocytic leukemia (T-CLL) with monoclonal proliferation of human T-lymphotropic retrovirus (HTLV)-I or HTLV-II negative CD3(+)4(+)8(-) T cell expressing IL-2 receptors without stimulation. " 06/01/2002 - "The high-affinity IL-2 receptor (IL-2Ralpha) is a major target of receptor-directed therapy in several human diseases, and it is constitutively expressed by the malignant cells in some T cell leukemias, suggesting an autocrine IL-2/IL-2R loop that participates in the expansion of leukemic IL-2R(+) cells. " 01/15/1990 - "Murine spontaneous T-cell leukemia constitutively expressing IL-2 receptor--a model for human T-cell malignancies expressing IL-2 receptor." 03/01/1989 - "The inhibitory activity of this element was retained in human T cell leukemia virus type-1 (HTLV-1)-infected T cell lines which express constitutively a large number of IL-2 receptors on the cell surface. " 11/01/1986 - "Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1."
10.	InterferonsIBA 04/25/2008 - "For this purpose, an infectious molecular clone of human T-cell leukemia virus type 1 (HTLV-1) was transfected into 293T or HeLa cells and was found to reduce interferon-stimulated response element (ISRE) reporter activity. " 06/01/1999 - "Normal and interferon (IFN)-gamma-activated HFRPE from early and late in vitro passages were incubated with cells from the human T-cell leukemia line Jurkat (Jkt). " 03/15/1987 - "Interferon has potent antiviral, antiproliferative, and immunomodulating properties, and therefore, this may be a good agent to treat such immune deficient patients with peripheral T-cell leukemia. " 04/01/1985 - "Interferon(IFN)-alpha and -beta strongly inhibited syncytia formation of human T-cell leukemia virus (HTLV). " 04/01/1985 - "Interferons inhibit syncytia-forming ability and in vitro transmission of human T-cell leukemia virus."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/2007 - "Chemotherapy induced complete remission, but the human T-cell leukemia virus type 1 (HTLV-1) proviral load was detected in mononuclear cells of her peripheral blood. " 09/01/2008 - "Chemotherapy led to sustained remission in 3 of the 4 cases of T cell leukemia, but failed in the fourth. " 06/15/2011 - "T-cell leukemia has a very poor prognosis, even with intensive chemotherapy, indicating the need for development of new drugs to treat the disease. " 08/01/2007 - "Human T-cell leukemia is a malignant disease that needs various regimens of cytotoxic chemotherapy to overcome drug resistance. " 08/01/2004 - "The proteinase of human T-cell leukemia virus type-1 (HTLV-1), similar to the proteinase of human immunodeficiency virus type-1 (HIV-1), is a potential target for chemotherapy, since the virus is associated with a number of human diseases. "
2.	Transplants (Transplant) 05/01/2003 - "Patient 1 was a 62-year-old man with chronic T-cell lymphocytic leukemia, and Patient 2 was a 54-year-old woman undergoing a cadaveric kidney transplant. " 12/01/2009 - "Sustained first remission in an adolescent with hepatosplenic T-cell lymphoma treated with T-cell leukemia induction, nucleoside analog-based consolidation, and early hematopoietic stem cell transplant." 12/01/2009 - "We report herein a unique case of CD4+ T-cell leukemia highly expressing Tax following rejection of an allogenic peripheral blood stem cell graft for an HTLV-1 associated lymphoma." 04/15/2003 - "Human T-cell leukemia virus type I infection in various recipients of transplants from the same donor." 09/01/2000 - "Inhibitors of PNP have been proposed for treatment of T-cell leukemia, to suppress the graft-vs.-host response, or to counter type IV autoimmune diseases without destroying humoral immunity. "
3.	Homologous Transplantation (Allograft) 12/01/2009 - "We report a durable, sustained first remission in an adolescent treated for HTCL who received induction therapy according to a high risk T-cell leukemia regimen, a nucleoside analog-based consolidation, and allogeneic transplantation associated with GVHD." 03/01/1994 - "Twenty-six biopsy specimens from immunocompromised patients, including allograft recipients and patients with AIDS, Wiscott-Aldrich syndrome, and human T-cell leukemia virus type 1 infection, in comparison with three Burkitt lymphomas and four Burkitt lymphoma cell lines were analyzed. " 03/01/2002 - "Humanized monoclonal antibodies that recognize IL-2Ra, the private receptor for IL-2, are being employed to inhibit allograft rejection and to treat T-cell leukemia/lymphoma. " 01/01/2007 - "Thus, translation of basic insights concerning the IL-2/IL-2 receptor system obtained using the monoclonal antibody daclizumab provided a useful strategy for the prevention of organ allograft rejection and the treatment of patients with select autoimmune diseases or T-cell leukemia/lymphoma." 01/01/2002 - "Humanized monoclonal antibodies that recognize IL-2Ralpha, the private receptor for IL-2, are being employed to inhibit allograft rejection and to treat T-cell leukemia/lymphoma. "
4.	Hematopoietic Stem Cell Transplantation 01/01/2015 - "To analyze the efficiency of the ALL-2009 protocol (ClinicalTrials.gov NCT01 193933) in patients with T-cell leukemias, particularly the role of autologous hematopoietic stem cell transplantation (auto-HSCT) after non-myeloablative BEAM conditioning, followed by maintenance therapy. " 04/15/2013 - "Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for adult T cell leukemia/lymphoma (ATL) caused by human T cell leukemia virus type 1 (HTLV-1). " 08/26/2010 - "Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used as a curative option for adult T-cell leukemia (ATL), an intractable mature T-cell neoplasm causally linked with human T-cell leukemia virus type I (HTLV-I). "
5.	Stem Cell Transplantation 04/12/2012 - "Allogeneic stem-cell transplantation from matched, related donors was associated with improved outcomes in T-cell leukemia. " 11/01/2005 - "Secondly, using clonal analysis, we could retrospectively show that the B-cell clone emerged during consolidation chemotherapy for T-cell leukemia, 3 months before stem cell transplantation." 04/12/2012 - "Patients who have T-cell leukemia appear to have a better outcome with allogeneic stem-cell transplantation than with chemotherapy, whereas patients who have precursor B-cell leukemia without other adverse features appear to have a better outcome with chemotherapy. " 11/01/2005 - "Here, we describe an 8-year old boy with early onset post-transplantation lymphoproliferative disorder following matched-unrelated stem cell transplantation for high-risk T-cell leukemia whose disease was unusual for two reasons. "