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Acute Biphenotypic Leukemia (Leukemia, Mixed Cell)

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An acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from MULTIPOTENT STEM CELLS.

Also Known As:

Leukemia, Mixed Cell; Leukemia, Biphenotypic, Acute; B and T Cell Acute Lymphoblastic Leukemia; B and T Cell Leukemia, Acute; Leukemia, Lymphocytic, Acute, Mixed Cell; Leukemia, Mixed, B and T Cell; Lymphocytic Leukemia, Acute, B and T Cell; Leukemias, Mixed-Cell; Mixed-Cell Leukemia; Mixed-Cell Leukemias; B- and T-Cell Acute Lymphoblastic Leukemia; B- and T-Cell Leukemia, Acute; Leukemia, Lymphocytic, Acute, Mixed-Cell; Leukemia, Mixed, B- and T-Cell; Leukemia, Mixed-Cell; Lymphocytic Leukemia, Acute, B- and T-Cell

Networked: 22 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Acute Monocytic Leukemia (Acute Monoblastic Leukemia)
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
5.	Essential Thrombocythemia

Experts

1.	Zhang, X-H: 1 article (07/2014)
2.	Kong, X-J: 1 article (07/2014)
3.	Yin, X-L: 1 article (07/2014)
4.	Chen, Y-S: 1 article (07/2014)
5.	Alrumaih, Redha: 1 article (01/2013)
6.	Saleem, Muhammad: 1 article (01/2013)
7.	Velagapudi, Suresh: 1 article (01/2013)
8.	Dababo, Mohammad Anas: 1 article (01/2013)
9.	Wu, Yu-Chin: 1 article (08/2011)
10.	Sun, Shung-Shung: 1 article (08/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Biphenotypic Leukemia:

1.	Phosphotransferases (Kinase)IBA 06/01/2008 - "In this study, we found that AZD6244 (ARRY-142886), a novel inhibitor of MEK1/2 kinases, effectively inhibited the proliferation of acute biphenotypic leukemia MV4-11 and acute monocytic leukemia MOLM13 cells. "
2.	AZD 6244IBA 06/01/2008 - "In this study, we found that AZD6244 (ARRY-142886), a novel inhibitor of MEK1/2 kinases, effectively inhibited the proliferation of acute biphenotypic leukemia MV4-11 and acute monocytic leukemia MOLM13 cells. "
3.	Messenger RNA (mRNA)IBA 09/01/1993 - "We observed that expression of TdT mRNA and sterile transcription at both the Ig and TCR loci (transcription without gene rearrangement) was unexpectedly common in both acute biphenotypic leukemia and acute myelogenous leukemia (AML), and occurred in the absence of phenotypic lymphoid differentiation. " 08/01/2003 - "Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia." 06/01/1998 - "Cyclin A1 mRNA was detectable in 11 of 11 patients with acute myeloid leukemia, three of three patients with acute biphenotypic leukemia, eight of eight patients with myelodysplastic syndrome, 59 of 69 patients with chronic myelogenous leukemia (CML) at diagnosis, 13 of 15 patients with CML in blastic transformation, 10 of 18 patients with chronic lymphocytic leukemia, two of nine patients with essential thrombocythemia, and only two of 10 patients with acute lymphoblastic leukemia (ALL) with both cyclin A1 RT-PCR positive ALL leukemias being undifferentiated relapses. "
4.	Cyclin A1IBA 06/01/1998 - "Cyclin A1 mRNA was detectable in 11 of 11 patients with acute myeloid leukemia, three of three patients with acute biphenotypic leukemia, eight of eight patients with myelodysplastic syndrome, 59 of 69 patients with chronic myelogenous leukemia (CML) at diagnosis, 13 of 15 patients with CML in blastic transformation, 10 of 18 patients with chronic lymphocytic leukemia, two of nine patients with essential thrombocythemia, and only two of 10 patients with acute lymphoblastic leukemia (ALL) with both cyclin A1 RT-PCR positive ALL leukemias being undifferentiated relapses. "
5.	Tryptophan (L-Tryptophan)FDA Link 02/01/1993 - "A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation. "
6.	Reticulin (Reticular Fiber)IBA 12/01/2006 - "Bridging necrosis and reticulin bridging fibrosis induced by intrahepatic involvement of acute biphenotypic leukemia."
7.	ParaffinIBA 11/01/1994 - "All cases that were TdT-positive by immunofluorescence (41 of 42 "pre-B" and T-cell acute lymphoblastic leukemia, 2 of 5 acute myeloid leukemia, and 1 of 5 chronic myeloid leukemia in blast crisis) were also positive in paraffin sections. "
8.	Immunoglobulins (Immunoglobulin)IBA 11/15/1991 - "The karyotypic abnormalities, t(9;22) and t(4;11), were noticed in acute biphenotypic leukemia, and were consistently associated with rearrangement at the immunoglobulin locus. "
9.	Hydroxyurea (Hydrea)FDA LinkGeneric 11/01/2009 - "Essential thrombocythemia transforming into acute biphenotypic leukemia in a patient on hydroxyurea monotherapy."
10.	Haloperidol (Haldol)FDA LinkGeneric 01/01/1984 - "[Induction of monocytic-myelocytic mixed cell leukemias after the application of the neuroleptic haloperidol in mice]."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 05/01/1993 - "We report on the isolation of Candida krusei and Candida tropicalis from 17 blood cultures that were taken from a 67-year-old white man with a diagnosis of acute biphenotypic leukemia during a 2-week period of hospitalization for induction chemotherapy. " 10/01/1989 - "In this paper is reported a case of acute biphenotypic leukemia who was treated by chemotherapy and pursued its effect by two color flow cytometry. " 08/01/2011 - "We report a case of a 25-year-old woman presented with neutropenic fever after chemotherapy for the relapse of acute biphenotypic leukemia. " 04/01/2004 - "An 18-year-old-male with acute biphenotypic leukemia developed massive gastrointestinal bleeding that was thought to be due to thrombocytopenia during chemotherapy-induced pancytopenia and did not respond to conventional therapy. " 02/01/1993 - "A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation. "
2.	Transplantation (Transplant Recipients) 07/01/2014 - "Treatment of acute mixed-cell leukemia with autologous hematopoietic SCT followed by allogeneic hematopoietic stem cell micro-transplantation." 02/01/1993 - "A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation. "
3.	Transplants (Transplant) 01/01/2013 - "A 31-year-old Arabian man who had acute biphenotypic leukemia treated with chemoradiation and allogeneic stem cell transplant was referred to our department with sore throat and a mass lesion in his lateral pharyngeal wall after failed antibiotic therapy. "
4.	Nutritional Support (Artificial Feeding) 02/01/1993 - "A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation. "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 07/01/1996 - "We present a female patient who received an allogeneic bone marrow transplantation for primary refractory Philadelphia-positive acute biphenotypic leukemia. "