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Lupus Erythematosus Panniculitis (Panniculitis, Lupus)

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A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

Also Known As:

Panniculitis, Lupus; Panniculitis, Lupus Erythematosus; Lupus Profundus; Lupus Erythematosus Panniculitides; Lupus Panniculitides; Panniculitides, Lupus; Panniculitides, Lupus Erythematosus; Lupus Erythematosus Profundus; Lupus Panniculitis

Networked: 64 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 8226
  - Cutaneous Lupus Erythematosus: 503
    - Discoid Lupus Erythematosus: 416
      - Lupus Erythematosus Panniculitis: 64
  - Panniculitis: 447
    - Lupus Erythematosus Panniculitis: 64
- Connective Tissue Diseases: 2260
  - Cutaneous Lupus Erythematosus: 503
    - Discoid Lupus Erythematosus: 416
      - Lupus Erythematosus Panniculitis: 64
  - Panniculitis: 447
    - Lupus Erythematosus Panniculitis: 64

Related Diseases

1.	Panniculitis
2.	Dermatomyositis (Dermatopolymyositis)
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
4.	Discoid Lupus Erythematosus
5.	Cicatrix (Scar)

Experts

1.	Nobbe, Stephan: 2 articles (04/2014 - 03/2014)
2.	Urosevic-Maiwald, Mirjana: 2 articles (04/2014 - 03/2014)
3.	Benz, Rudolf: 2 articles (04/2014 - 03/2014)
4.	Kerl, Katrin: 2 articles (04/2014 - 03/2014)
5.	Magro, Cynthia M: 2 articles (05/2013 - 09/2012)
6.	Wang, Xuan: 2 articles (05/2013 - 09/2012)
7.	Callen, Jeffrey P: 2 articles (07/2010 - 03/2004)
8.	Wong, Se Mang: 1 article (12/2015)
9.	Shiau, Carolyn J: 1 article (12/2015)
10.	Crawford, Richard I: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lupus Erythematosus Panniculitis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2006 - "A 29-year-old woman had lupus profundus since 1999, initially associated with thrombopenia (28,000 platelets/mm3) treated with corticosteroids for 6 months. " 07/01/2010 - "Antimalarials are the initial treatment of choice for most cases of lupus erythematosus panniculitis, whereas corticosteroids in combination with other steroid-sparing immunosuppressive agents are the first-line treatment for panniculitis in patients with dermatomyositis. " 01/01/2000 - "We report a young female patient with recurrent lupus erythematosus profundus (LEP) who has successfully maintained remission of LEP with cyclosporin A (CsA), although conventional treatments such as systemic corticosteroids (low-dose), dapsone, and other immunosuppressive drugs (azathiopurine, cyclophosphamide) could not maintain remission." 12/01/2009 - "We treated one patient with subacute LE having a contraindication to antimalarials and to thalidomide and three patients with chronic LE (lupus panniculitis, lupus tumidus and disseminated discoid LE) refractory to treatment with hydroxychloroquine, chloroquine, thalidomide and dapsone, and also, in some cases, to oral and intravenous corticosteroids, methotrexate, colchicine, acitretine, sulfasalazine, mycophenolate mofetil and intravenous immunoglobulin. "
2.	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 03/01/1975 - "Analysis of these six cases and those previously reported suggests that the addition of hydroxychloroquine to the treatment regimen may be beneficial in lupus panniculitis." 12/01/2006 - "While being treated with hydroxychloroquine for a recent flare-up of nodular lesions of lupus profundus, she complained of paraesthesia of the abdominal wall and of the upper and lower limbs, suggestive of a medullary lesion. " 04/01/1987 - "Lupus profundus in children: treatment with hydroxychloroquine." 09/01/1997 - "Lupus panniculitis treated by a combination therapy of hydroxychloroquine and quinacrine." 04/01/1987 - "These patients, the second and third in the English literature to be treated for childhood lupus profundus with antimalarials, responded successfully to hydroxychloroquine. "
3.	Dapsone FDA Link 03/01/2006 - "Lupus erythematosus profundus successfully treated with dapsone: review of the literature." 10/01/1989 - "Lupus erythematosus profundus--report of a case treated with dapsone." 01/01/2000 - "We report a young female patient with recurrent lupus erythematosus profundus (LEP) who has successfully maintained remission of LEP with cyclosporin A (CsA), although conventional treatments such as systemic corticosteroids (low-dose), dapsone, and other immunosuppressive drugs (azathiopurine, cyclophosphamide) could not maintain remission." 12/01/2009 - "We treated one patient with subacute LE having a contraindication to antimalarials and to thalidomide and three patients with chronic LE (lupus panniculitis, lupus tumidus and disseminated discoid LE) refractory to treatment with hydroxychloroquine, chloroquine, thalidomide and dapsone, and also, in some cases, to oral and intravenous corticosteroids, methotrexate, colchicine, acitretine, sulfasalazine, mycophenolate mofetil and intravenous immunoglobulin. "
4.	Antimalarials (Antimalarial Agents)IBA 01/01/2010 - "The evolution of lupus panniculitis is slow and characterized by regression of the inflammatory lesions when treated with antimalarial drugs. " 04/01/1987 - "These patients, the second and third in the English literature to be treated for childhood lupus profundus with antimalarials, responded successfully to hydroxychloroquine. " 07/01/2010 - "Antimalarials are the initial treatment of choice for most cases of lupus erythematosus panniculitis, whereas corticosteroids in combination with other steroid-sparing immunosuppressive agents are the first-line treatment for panniculitis in patients with dermatomyositis. " 12/01/2009 - "We treated one patient with subacute LE having a contraindication to antimalarials and to thalidomide and three patients with chronic LE (lupus panniculitis, lupus tumidus and disseminated discoid LE) refractory to treatment with hydroxychloroquine, chloroquine, thalidomide and dapsone, and also, in some cases, to oral and intravenous corticosteroids, methotrexate, colchicine, acitretine, sulfasalazine, mycophenolate mofetil and intravenous immunoglobulin. "
5.	Thalidomide (Thalomid)FDA Link 03/01/2008 - "We report a severe, mutilating case of lupus panniculitis, which responded well to thalidomide." 03/01/2008 - "Facets of lupus erythematosus: panniculitis responding to thalidomide." 07/01/1991 - "Lupus erythematosus profundus with partial C4 deficiency responding to thalidomide." 12/01/2009 - "We treated one patient with subacute LE having a contraindication to antimalarials and to thalidomide and three patients with chronic LE (lupus panniculitis, lupus tumidus and disseminated discoid LE) refractory to treatment with hydroxychloroquine, chloroquine, thalidomide and dapsone, and also, in some cases, to oral and intravenous corticosteroids, methotrexate, colchicine, acitretine, sulfasalazine, mycophenolate mofetil and intravenous immunoglobulin. "
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2000 - "Maintaining remission of lupus erythematosus profundus (LEP) with cyclosporin A." 09/01/2012 - "Intractable ulceration in a patient with lupus erythematosus profundus successfully treated with cyclosporine." 01/01/2000 - "We report a young female patient with recurrent lupus erythematosus profundus (LEP) who has successfully maintained remission of LEP with cyclosporin A (CsA), although conventional treatments such as systemic corticosteroids (low-dose), dapsone, and other immunosuppressive drugs (azathiopurine, cyclophosphamide) could not maintain remission."
7.	Hepatitis B Vaccines (Hepatitis B Vaccine)IBA 01/01/2007 - "We report the case of a woman followed for a lupus panniculitis which had been in remission for 3 years, who developed a lupus flare following an anti-hepatitis-B vaccine injection. "
8.	Immunosuppressive Agents (Immunosuppressants)IBA 07/01/2010 - "Antimalarials are the initial treatment of choice for most cases of lupus erythematosus panniculitis, whereas corticosteroids in combination with other steroid-sparing immunosuppressive agents are the first-line treatment for panniculitis in patients with dermatomyositis. "
9.	Diltiazem (Cardizem)FDA LinkGeneric 09/01/2001 - "The addition of diltiazem may be beneficial in patients with calcified nodules of lupus panniculitis." 09/01/2001 - "Calcifying lupus panniculitis in a patient with subacute cutaneous lupus erythematosus: response to diltiazem and chloroquine."
10.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2000 - "We report a young female patient with recurrent lupus erythematosus profundus (LEP) who has successfully maintained remission of LEP with cyclosporin A (CsA), although conventional treatments such as systemic corticosteroids (low-dose), dapsone, and other immunosuppressive drugs (azathiopurine, cyclophosphamide) could not maintain remission."

Therapies and Procedures

1.	Transplants (Transplant) 05/01/1986 - "Multiple dermal grafts for hemifacial atrophy caused by lupus panniculitis." 02/01/1992 - "Included herein are Shulman's eosinophilic fasciitis, morphea profunda, lupus profundus, venous lipodermatosclerosis, toxic oil syndrome, altered tryptophane-related eosinophilic myositis, graft-versus-host reaction, and fasciitis reactive to subjacent basal cell carcinoma. "
2.	Hydrocolloid Bandages (Duoderm) 01/01/1993 - "Lupus erythematosus profundus treated with clobetasol propionate under a hydrocolloid dressing."
3.	Highly Active Antiretroviral Therapy (HAART) 04/01/2015 - "It may be also a manifestation of chronic diseases, most frequently it affects HIV-infected individuals treated with highly active antiretroviral therapy (HAART) and may constitute a complication of connective tissue diseases, like lupus erythematosus profundus or morphea. "