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Scleritis (Episcleritis)

Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
Also Known As:
Episcleritis; Necrotizing Scleritis; Episcleritides; Necrotizing Scleritides; Scleritides; Scleritides, Necrotizing; Scleritis, Necrotizing
Networked: 910 relevant articles (109 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Inflammation (Inflammations)
2. Uveitis
3. Rheumatoid Arthritis
4. Retinal Detachment (Retinal Detachments)
5. Keratitis

Experts

1. Foster, C Stephen: 24 articles (01/2022 - 09/2002)
2. Thorne, Jennifer E: 13 articles (01/2022 - 12/2002)
3. Jabs, Douglas A: 11 articles (01/2022 - 03/2004)
4. Rosenbaum, James T: 11 articles (01/2022 - 10/2006)
5. Biswas, Jyotirmay: 11 articles (11/2021 - 02/2006)
6. Nussenblatt, Robert B: 10 articles (01/2022 - 09/2003)
7. Suhler, Eric B: 10 articles (01/2022 - 09/2003)
8. Kempen, John H: 9 articles (01/2022 - 08/2005)
9. Sen, H Nida: 7 articles (01/2022 - 09/2003)
10. Cunningham, Emmett T: 6 articles (10/2021 - 12/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Scleritis:
1. SteroidsIBA
2. Adrenal Cortex Hormones (Corticosteroids)IBA
3. Rituximab (Mabthera)FDA Link
4. Infliximab (Remicade)FDA Link
5. Prednisolone (Predate)FDA LinkGeneric
6. GlucocorticoidsIBA
7. Cyclophosphamide (Cytoxan)FDA LinkGeneric
8. Methotrexate (Mexate)FDA LinkGeneric
9. Anti-Bacterial Agents (Antibiotics)IBA
10. Cyclosporine (Ciclosporin)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Injections
4. Debridement
5. Biological Therapy