Histocompatibility Antigens Class I

Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice, three genes named K, D, and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders.

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Networked: 587 relevant articles (11 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ferrone, Soldano: 11 articles (12/2007 - 05/2003)
2.	Seliger, Barbara: 8 articles (01/2014 - 05/2003)
3.	Garrido, Federico: 8 articles (10/2010 - 02/2005)
4.	Sigalotti, Luca: 5 articles (03/2013 - 06/2003)
5.	Maio, Michele: 5 articles (03/2013 - 06/2003)
6.	Aptsiauri, Natalia: 5 articles (07/2010 - 01/2007)
7.	Cabrera, Teresa: 5 articles (07/2010 - 01/2007)
8.	Coral, Sandra: 4 articles (03/2013 - 06/2003)
9.	Colizzi, Francesca: 4 articles (03/2013 - 06/2003)
10.	Ruiz-Cabello, Francisco: 4 articles (08/2008 - 01/2007)

Related Diseases

1.	Neoplasms (Cancer) 09/01/1996 - "Such studies will not only provide improved understanding of the mechanisms of tumor escape, but also will suggest strategies to repair cellular defects in cancer patients having impaired expression of MHC class I antigens." 07/01/2005 - "We hypothesize that the majority of tumor cells with normal HLA class I expression were attacked and eradicated by CTLs, and only a minority with an abnormal expression of HLA class I antigens could escape the host's immunosurveillance system. " 04/01/2000 - "This study shows that the use of a semiquantitative WB technique can well define the levels of HLA class I antigens in an autologous setting allowing the biochemical analysis of HLA class I downregulation directly in solid tumor tissues. " 10/01/1991 - "These studies demonstrate a requirement for class I antigens, but suggest that additional factors may also be required for tumor-specific immunity. " 03/01/1990 - "Previous studies have shown that increased expression of oncogenes from the myc-family can down-regulate the level of MHC class I antigens in tumor cells. "
2.	Melanoma (Melanoma, Malignant) 07/01/1991 - "Induction of HLA class I antigens on cultured melanoma cells FO-1 after transfection with a human or a mouse B2m gene was associated with a statistically significant reduction in their susceptibility to natural killer (NK) cell-mediated lysis. " 01/01/2010 - "Suboptimal activation of T lymphocytes by melanoma cells is often due to the defective expression of class I major histocompatibility antigens (MHC-I) and costimulatory molecules. " 01/01/2007 - "We observed two distinct mechanisms of loss of IFN-gamma inducibility of HLA class I antigens in two melanoma cell lines. " 01/01/2007 - "Altered expression of MHC class I antigens is frequently found on melanoma cells, preventing recognition by specific cytolytic T cells but favouring NK cell recognition. " 06/20/2003 - "Methylation-regulated expression of HLA class I antigens in melanoma."
3.	Neuroblastoma 05/01/1990 - "We recently showed that transfection of the rat neuroblastoma cell line B104 with an N-myc expression vector resulted in an increase in metastatic ability and a significant reduction in the expression of major histocompatibility complex class I antigens. " 02/01/2001 - "Surface expression of HLA class I antigens was low in eight out of eight neuroblastoma cell lines bearing MYC-N amplification and/or 1p deletion, while two out of three neuroblastoma cell lines lacking these genetic alterations showed normal expression. " 05/25/1993 - "In neuroblastomas, it was proposed that down-modulation of MHC Class I antigens is a consequence of N-myc amplification and that this could be important in the progression toward a metastatic phenotype.(ABSTRACT TRUNCATED AT 400 WORDS)" 01/01/1993 - "Transfection of a p50 expression vector in neuroblastoma cells that express N-myc at a high level leads to restoration of factor binding to the MHC Class I gene enhancer, restores enhancer activity and leads to re-expression of MHC Class I antigens at the cell surface. " 01/01/1993 - "In neuroblastoma, N-myc suppresses the expression of major histocompatibility complex (MHC) Class I antigens by reducing the binding of a nuclear factor to the enhancer-A element in the MHC Class I gene promoter. "
4.	Colonic Neoplasms (Colon Cancer) 12/15/1990 - "The expression of HLA class I antigens in colon cancer was dramatically reduced compared to control (P less than 0.0001): undetectable in 28%, diminished in 68%, normal in 4%. " 03/01/1992 - "The human colon cancer cell line HCT does not express any detectable HLA class I antigens on the cell surface. " 12/01/1996 - "Thus, these eicosanoids are an unlikely regulator of the observed underexpression of MHC class I antigens in human colon cancer." 03/01/1992 - "Beta 2-microglobulin gene is mutated in a human colon cancer cell line (HCT) deficient in the expression of HLA class I antigens on the cell surface." 06/01/1994 - "We studied the effect of bile acids (BAs), long implicated in the pathogenesis of colon cancer, on the expression of HLA class I antigens in human colon adenocarcinoma cells. "
5.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 02/01/1998 - "The role of major histocompatibility complex (MHC) class I antigens and adhesion molecules (AM) in the resistance of leukemic B-cells to cell-mediated cytotoxicity was investigated using cells from eight patients with B-chronic lymphocytic leukemia (B-CLL) and six patients with immunocytoma (IC). " 04/10/2001 - "Although the B cells of chronic lymphocytic leukemia (B-CLL cells) express both tumor-specific peptides and major histocompatibility complex (MHC) class I antigens, they lack the capacity for costimulatory signaling, contributing to their protection against host antitumor immunity. " 03/01/2001 - "HLA class I antigens were investigated in 225 cases with various kinds of leukemia: 112 patients with acute myeloblastic leukemia (AML), 31 with acute lymphoblastic leukemia (ALL), 44 with chronic myelocytic leukemia (CML) and 38 with chronic lymphocytic leukemia (CLL). "

Related Drugs and Biologics

1.	Antigens
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	DNA (Deoxyribonucleic Acid)
4.	HLA-A Antigens (HLA-A)
5.	Peptides
6.	Protein Sorting Signals (Signal Peptide)
7.	Antibodies
8.	Immunoglobulins (Immunoglobulin)
9.	I-antigen
10.	Cell Adhesion Molecules

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Immunotherapy
3.	Homologous Transplantation (Allograft)
4.	Aftercare (After-Treatment)
5.	Heterologous Transplantation (Xenotransplantation)