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Interferon Alfa-2b (Interferon Alfa 2b)

Subscribe to New Research on Interferon Alfa-2b

A recombinant alfa interferon consisting of 165 amino acid residues with arginine in position 23 and histidine in position 34. It is used extensively as an antiviral and antineoplastic agent.

Also Known As:

Interferon Alfa 2b; Intron A (Interferon); Recombinant Interferon alpha-2b; Sch-30500; Interferon Alfa-2b, Recombinant; Interferon alpha-2b, Recombinant; Recombinant Interferon Alfa 2b; Recombinant Interferon alpha 2b; Sch 30500; Sch30500; Recombinant Interferon Alfa-2b; Inteferon alpha 2b (human leukocyte clone Hif-SN 206 protein moiety reduced).

Networked: 597 relevant articles (74 outcomes, 152 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kirkwood, John M: 7 articles (11/2014 - 01/2004)
2.	Hauschild, Axel: 6 articles (12/2015 - 08/2003)
3.	Gogas, Helen: 4 articles (12/2015 - 05/2004)
4.	Weichenthal, Michael: 4 articles (12/2015 - 08/2003)
5.	Atkins, Michael B: 4 articles (11/2014 - 01/2005)
6.	Zeuzem, Stefan: 4 articles (09/2012 - 07/2003)
7.	Eggermont, Alexander M M: 4 articles (05/2010 - 10/2005)
8.	Suciu, Stefan: 4 articles (05/2010 - 10/2005)
9.	Dieterich, Douglas T: 4 articles (12/2008 - 02/2004)
10.	Schäfer, Arne: 4 articles (04/2007 - 06/2003)

Related Diseases

1.	Chronic Hepatitis C 01/01/1993 - "Efficacy of different regimens of interferon alfa-2b treatment in chronic hepatitis C." 11/01/2000 - "A multicenter, randomized trial of daily high-dose interferon-alfa 2b for the treatment of chronic hepatitis c: pretreatment stratification by viral burden and genotype." 01/01/2000 - "The aim of this study was to evaluate the most appropriate therapeutic protocol for patients with chronic hepatitis C not responding to a previous course of recombinant interferon alpha-2b (rIFN). " 07/01/1998 - "Seventy patients with chronic hepatitis C who participated in two trials of recombinant interferon alpha 2b treatment were studied. " 09/01/1997 - "We performed an independent meta-analysis of all available randomized clinical trials of interferon alfa-2b in patients with chronic hepatitis C. "
2.	Melanoma (Melanoma, Malignant) 02/22/2001 - "The best results of adjuvant treatment in high-risk resected melanoma were published in 1996 by Kirkwood, who used interferon-alfa 2b. " 06/01/1999 - "In patients with stage IIb and III melanoma, the best results have been obtained with high doses of interferon alfa-2b, although toxicity is of concern. " 02/01/2001 - "Although trials of adjuvant interferon alfa-2b (IFN alpha-2b) in high-risk melanoma patients suggest improvement in disease-free survival, it is unclear whether treatment offers improvement in overall survival. " 07/01/2012 - "Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2." 08/01/1998 - "Adjuvant therapy with interferon alfa-2b holds promise for patients with metastatic melanoma. "
3.	Hepatitis C 09/01/1993 - "Concurrent with the cloning and development of the anti-HCV screening tests, trials with interferon alfa-2b have documented biochemical and histologic improvement in the indices of hepatitis C and non-A, non-B (NANB) in patients who were chronically infected. " 11/01/1994 - "To evaluate the efficacy of recombinant interferon alpha-2b in the treatment of patients with acute post-transfusion hepatitis C, a randomized controlled trial was conducted in 33 acute post-transfusion hepatitis C patients; 16 patients received 3 million units of subcutaneously injected recombinant interferon alpha-2b 3 times a week for 3 months and 17 patients without specific treatment were used as controls. " 01/01/2002 - "Four trials assessing interferon alfa-2b in 141 patients, all with transfusion-acquired acute hepatitis C, were included. " 09/01/1997 - "Therapy of hepatitis C: meta-analysis of interferon alfa-2b trials." 12/01/2007 - "We report the successful use of electroconvulsive therapy in a patient who developed major depression with psychotic features while being treated with interferon alfa-2b for hepatitis C. "
4.	Chronic Hepatitis B 01/01/1990 - "Our data indicate that small doses of recombinant interferon alfa-2b given during a 12-week period induce a significant reduction in viral replication and approximately triple the spontaneous seroconversion rate observed in patients with chronic hepatitis B." 08/02/1990 - "In chronic hepatitis B, treatment with interferon alfa-2b (5 million units per day for 16 weeks) was effective in inducing a sustained loss of viral replication and achieving remission, assessed biochemically and histologically, in over a third of patients. " 04/01/2005 - "Safety and efficacy of an indigenous human recombinant interferon alpha 2b (Shanferon) in patients with chronic hepatitis B." 01/01/1993 - "This paper reviews the results of recent studies carried out in the USA on the treatment of chronic hepatitis B with interferon alfa-2b. " 05/01/2002 - "[Interferon alfa 2b treatment decreases histological activity in children with chronic hepatitis B]."
5.	Neoplasms (Cancer) 01/01/1987 - "Both in vitro and in vivo studies have demonstrated antiproliferative effects of interferon alfa-2b (Intron A; Schering-Plough) when tested with human tumor cells. " 02/01/2012 - "According to American Joint Committee on Cancer classification, complete control with topical interferon alfa-2b can be achieved in 67% of Tis, 85% of T3, and 83% of all OSSN." 02/01/2012 - "Complete tumor resolution was achieved in 19 tumors (83%) following topical interferon alfa-2b treatment for a median period of 6 months (mean, 7 months; range, 1-12 months) and maintained for up to 24 months of follow-up. " 02/01/2012 - "Clinically visible OSSN in 20 patients (23 tumors) was managed with topical interferon alfa-2b, 1 million IU/mL, 4 times daily. " 02/01/2012 - "Topical interferon alfa-2b for management of ocular surface squamous neoplasia in 23 cases: outcomes based on American Joint Committee on Cancer classification."

Related Drugs and Biologics

1.	Ribavirin (Virazole)
2.	Interferons
3.	Prednisone (Sone)
4.	Fluorouracil (Carac)
5.	peginterferon alfa-2b (Pegintron)
6.	Hepatitis B e Antigens
7.	Interferon Alfa-2a (Interferon Alfa 2a)
8.	Interleukin-2 (IL2)
9.	Dacarbazine (DIC)
10.	Interferon-alpha (Interferon Alfa)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Nephrectomy
5.	Injections