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Recombinant Interferon Type I

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A type I interferon with antiviral and antineoplastic activity produced by recombinant DNA technology. It can be a mixture of alpha and beta interferons.

Also Known As:

Interferon Type I, Recombinant; Alpha, Recombinant Interferon; Beta, Recombinant Interferon; Recombinant Interferon Alfa; Recombinant Interferon Alpha; Recombinant Interferon Beta; Interferon Alfa, Recombinant; Interferon Alpha, Recombinant; Interferon Beta, Recombinant

Networked: 477 relevant articles (42 outcomes, 73 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Silver, Richard T: 5 articles (08/2015 - 05/2005)
2.	Hou, Jin-lin: 4 articles (07/2007 - 12/2003)
3.	Luo, Kang-xian: 4 articles (07/2007 - 12/2003)
4.	Liu, Ding-li: 3 articles (07/2007 - 04/2004)
5.	Zhang, Ming-xia: 3 articles (06/2007 - 12/2003)
6.	Hasselbalch, Hans Carl: 2 articles (08/2015 - 09/2013)
7.	Ackerstein, Aliza: 2 articles (04/2010 - 06/2007)
8.	Or, Reuven: 2 articles (04/2010 - 06/2007)
9.	Roggendorf, Michael: 2 articles (01/2008 - 10/2002)
10.	Lu, Mengji: 2 articles (01/2008 - 10/2002)

Related Diseases

1.	Chronic Hepatitis C 01/01/2004 - "Recombinant interferon-alpha (IFN-alpha ) is widely used for the treatment of chronic hepatitis C. " 12/01/1995 - "The efficacy of recombinant interferon-alfa therapy in children with chronic hepatitis C has been evaluated in a randomized, controlled pilot study including 27 patients, aged 2 to 14 years, without underlying systemic diseases. " 09/01/1994 - "Six patients with chronic hepatitis C who were cured of malignancy were treated with recombinant interferon-alpha at the dose of 4 MU/m2 for 12 months; the post-treatment follow up period was 12 months. " 01/01/1991 - "Efficacy of long term recombinant interferon-alfa in patients with chronic hepatitis C. " 01/01/2000 - "We conducted a study of recombinant interferon-alpha therapy in 10 children with chronic hepatitis C. "
2.	Polycythemia Vera 08/15/1990 - "Recombinant interferon alfa, a natural product with growth inhibitory capabilities, has been demonstrated for the first time to have significant therapeutic efficacy in controlling the red cell mass in patients with the myeloproliferative disease polycythemia vera. " 01/01/1998 - "The therapeutic efficacy of recombinant interferon-alpha (rIFN-alpha) has been evaluated in 7 patients with polycythaemia vera (PV), diagnosed according to the criteria of the Polycythemia Vera Study Group. " 08/15/1990 - "A new treatment for polycythemia vera: recombinant interferon alfa." 08/01/2006 - "Long-term effects of the treatment of polycythemia vera with recombinant interferon-alpha." 01/01/1996 - "In previous researches recombinant interferon alpha (IFN-alpha) has been demonstrated to significantly control red cell mass and thrombocytemia in patients with polycythemia vera (PV). "
3.	Renal Cell Carcinoma (Grawitz Tumor) 02/01/1995 - "EORTC (30885) randomised phase III study with recombinant interferon alpha and recombinant interferon alpha and gamma in patients with advanced renal cell carcinoma. " 09/01/1990 - "Phase II study of recombinant interferon alpha-C in patients with metastatic renal cell carcinoma." 01/01/1990 - "Phase I/II study of recombinant interferon alpha and gamma in advanced progressive renal-cell carcinoma." 01/01/1990 - "Five out of 38 patients (13%) with metastatic renal cell carcinoma had mental deterioration 3 weeks to 13 months after the start of treatment with recombinant interferon alpha-C. " 06/01/1988 - "Recombinant interferon alpha and gamma in combination as treatment for metastatic renal cell carcinoma."
4.	Neoplasm Metastasis (Metastasis) 12/01/1990 - "Distribution of human recombinant interferon-alpha 2 in rat plasma, liver, and experimental liver metastases." 02/01/1994 - "We report on a 37-year-old woman with progressive lung and pleural metastases from a right nephroblastoma, who achieved partial remission with recombinant interferon-alpha. " 04/15/2002 - "To correlate the presence of extracapsular spread (ECS) of regional nodal metastases, and micrometastasis near the primary tumor, with disease outcome in the intergroup study E1690 in relation to the impact of recombinant interferon-alfa (rIFN alpha)-2b. " 11/01/2001 - "A 76-year-old man with postoperative renal cell carcinoma accompanied by multiple lung metastasis was being treated with recombinant interferon-alpha. " 05/01/1993 - "Intralesional therapy of melanoma metastases with recombinant interferon-beta]."
5.	Melanoma (Melanoma, Malignant) 06/15/1997 - "On the basis of the activity demonstrated in vitro against melanoma cell lines and the results obtained in many clinical trials in patients with advanced melanoma, the authors chose to study the use of recombinant interferon-alpha (IFN-alpha) as adjuvant therapy for patients with Stage I and Stage II melanoma. " 06/01/1990 - "A phase Ia-Ib study was undertaken to treat melanoma patients with a constant dose of the anti-GD3 monoclonal antibody, R24, in combination with increasing dose levels of recombinant interferon-alpha (rHuIFN alpha-2a). " 02/01/1997 - "Recombinant interferon alpha (rIFN-alpha) has shown antitumor activity in metastatic malignant melanoma both as single-agent therapy and in combination with chemotherapeutic agents. " 02/20/1991 - "Recombinant interferon alpha and gamma modulate the invasive potential of human melanoma in vitro." 09/01/1986 - "Treatment of metastatic malignant melanoma with recombinant interferon alpha 2."

Related Drugs and Biologics

1.	Interferon-alpha (Interferon Alfa)
2.	Interleukin-2 (IL2)
3.	Interferons
4.	Ribavirin (Virazole)
5.	Antibodies
6.	Cisplatin (Platino)
7.	interferon-alpha 2
8.	Cytostatic Agents
9.	Eflornithine (Ornidyl)
10.	Ursodeoxycholic Acid (Urso)

Related Therapies and Procedures

1.	Immunotherapy
2.	Aftercare (After-Treatment)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Drug Therapy (Chemotherapy)
5.	Liver Transplantation