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Enoxacin (AT 2266)

A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (FLUOROQUINOLONES) structurally related to NALIDIXIC ACID.

Also Known As:

AT 2266; AT-2266; CI-919; Enoxacin Sesquihydrate; Enoxin; Enoxor; Faulding Brand of Enoxacin; PD-107779; Penetrex; Pierre Fabre Brand of Enoxacin Sesquihydrate; Rhône-Poulenc Rorer Brand of Enoxacin Sesquihydrate; AT2266; CI 919; CI919; PD 107779; PD107779; Rhône Poulenc Rorer Brand of Enoxacin Sesquihydrate; Sesquihydrate, Enoxacin; 1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-

Networked: 228 relevant articles (48 outcomes, 58 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Quinolines: 92
    - Quinolones: 1190
      - Fluoroquinolones: 2005
        Enoxacin: 228
        4-oxo-enoxacin: 1
        CP 99433

Experts

1.	Holliday, L Shannon: 4 articles (01/2015 - 08/2009)
2.	Toro, Edgardo J: 3 articles (01/2014 - 08/2009)
3.	Hori, Seiji: 3 articles (04/2009 - 08/2003)
4.	Kizu, Junko: 3 articles (04/2009 - 08/2003)
5.	Velsko, Irina M: 2 articles (01/2015 - 01/2014)
6.	Kesavalu, Lakshmyya: 2 articles (01/2015 - 01/2014)
7.	Chukkapalli, Sasanka S: 2 articles (01/2015 - 01/2014)
8.	Wronski, Thomas J: 2 articles (03/2012 - 08/2009)
9.	Ostrov, David A: 2 articles (03/2012 - 08/2009)
10.	Fukuda, Hitoshi: 2 articles (02/2003 - 06/2002)

Related Diseases

1.	Infection 01/01/1989 - "Enoxacin appears a very effective and safe drug in the treatment of the infections of the lower respiratory tract." 09/01/1987 - "In vivo efficacy of 7e was superior to that of enoxacin against experimental infections due to S. " 07/01/1988 - "In uncomplicated gonococcal infections single oral doses of enoxacin were effective in over 90% of patients. " 02/01/1988 - "In systemic mouse infections, enoxacin was effective in a single oral or subcutaneous dose against one strain each of Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Providencia rettgeri and Ps. " 07/01/1993 - "Oral enoxacin appears to be a safe and effective method of treatment for anogenital infections caused by N. "
2.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1986 - "In vitro activity, pharmacokinetics, clinical safety and therapeutic efficacy of enoxacin in the treatment of patients with complicated urinary tract infections." 09/01/1985 - "In vitro activity, pharmacokinetics, clinical safety and therapeutic efficacy of enoxacin in the treatment of patients with complicated urinary tract infections." 09/01/1992 - "In this study we evaluated the efficacy of enoxacin in treating complicated urinary tract infections (UTI). " 02/01/1988 - "An open study of the safety and efficacy of enoxacin in complicated urinary tract infections." 01/01/1989 - "Tissue penetration and clinical efficacy of enoxacin in urinary tract infections."
3.	Prostatitis 01/01/1996 - "Noncomparative data suggest that enoxacin is also an effective agent for the treatment of prostatitis. " 03/01/2010 - "This study aimed to investigate the clinical efficacy of enoxacin in the treatment of III A prostatitis. " 06/17/1995 - "[Efficacy of enoxacin in the treatment of prostatitis-vesiculitis: its absence of toxicity on spermatogenesis]." 11/01/1989 - "The clinical efficacy of enoxacin (ENX) was evaluated in 39 patients having chronic prostatitis. " 03/01/2010 - "Enoxacin has desirable efficacy and few adverse effects on type III A prostatitis."
4.	Bacterial Infections (Bacterial Infection) 02/01/1988 - "Enoxacin exhibits a high degree of penetration into sputum which may prove useful in the treatment of bacterial infections of the respiratory tract." 01/01/1993 - "Enoxacin is a quinolone antibacterial agent currently being developed for oral and intravenous treatment of bacterial infections. " 06/30/1989 - "[Enoxacin in the treatment of bacterial infections of the respiratory system]." 01/15/1989 - "[Enoxacin in the treatment of bacterial infections of the urinary tract]." 01/01/1989 - "The present report concerns an open clinical trial aimed to investigate the efficacy and safety of enoxacin (Zami 8401), a new quinolone drug, in bacterial infections of the lower respiratory tract. "
5.	Gonorrhea 07/01/1989 - "gonorrhoeae isolated in this study was 0.06 microgram/ml. Enoxacin appears to be a well tolerated, efficacious alternative to currently recommended therapy for patients with uncomplicated, anogenital gonorrhea including cases potentially caused by antibiotic resistant N. " 04/01/1987 - "In a double-blind randomized study, 155 male patients with uncomplicated urethral gonorrhea were given 200 mg (one capsule with 200 mg and one capsule with placebo; n = 77) or 400 mg (two capsules with 200 mg; n = 78) of enoxacin orally. " 04/01/1992 - "A review of clinical data confirmed the utility of a single 400-mg oral dose of enoxacin for treating gonorrhea caused by strains judged to be susceptible by the proposed criteria. " 04/01/1989 - "Single dose enoxacin for the treatment of uncomplicated urogenital gonorrhea." 04/01/1987 - "Comparative double-blind study of 200- and 400-mg enoxacin given orally in the treatment of acute uncomplicated urethral gonorrhea in males."

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Ofloxacin (Levofloxacin)
3.	Ceftriaxone (Ceftriaxon)
4.	Norfloxacin
5.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
6.	Amoxicillin (Wymox)
7.	temafloxacin
8.	Trimethoprim (Proloprim)
9.	Quinolones
10.	Pefloxacin

Related Therapies and Procedures

1.	Oral Administration
2.	Transurethral Resection of Prostate (TURP)
3.	Antibiotic Prophylaxis
4.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
5.	Injections