Molecular Probes (Molecular Probe)

A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.

Also Known As:

Networked: 819 relevant articles (28 outcomes, 126 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cheng, Zhen: 20 articles (01/2021 - 05/2005)
2.	Achilefu, Samuel: 19 articles (01/2020 - 08/2004)
3.	Tan, Weihong: 14 articles (07/2020 - 08/2006)
4.	Gambhir, Sanjiv S: 9 articles (12/2016 - 04/2004)
5.	Qiao, Ruirui: 8 articles (04/2020 - 07/2009)
6.	Shangguan, Dihua: 7 articles (12/2021 - 08/2006)
7.	Gao, Mingyuan: 7 articles (04/2020 - 07/2009)
8.	Akers, Walter J: 7 articles (01/2016 - 07/2010)
9.	Liu, Hongguang: 7 articles (12/2013 - 11/2009)
10.	Tian, Jie: 6 articles (07/2022 - 07/2013)

Related Diseases

1.	Neoplasms (Cancer) 11/23/2021 - "Sensitivity and specificity of molecular probes are two important factors in determining the accuracy of cancer diagnosis or the efficacy of cancer treatment. " 01/01/2018 - "This study reveals the advantage of using a combination of receptor-mediated cell uptake and molecular-target-triggered activation to design molecular probes for improved cancer imaging, which could facilitate effective cancer diagnoses." 01/01/2020 - "Activatable molecular probes hold great promise for targeted cancer imaging. " 07/01/2009 - "Therefore, tissue slide-based SELEX holds promise in identifying tumour markers and developing specific molecular probes for cancer diagnosis." 10/01/2022 - "This study highlights the potential of using L6-PEG2K as self-assembling molecular probes with long-circulation persistence for routine preoperative tumor assessment and precise intraoperative image-guided resection."
2.	Mycoplasma Infections 01/01/1992 - "The utilization of pre-screened reagents and antibiotic-free cultivation, plus the application of improved procedures, such as fluorescent dyes and molecular probes for detection, provide effective means to avoid mycoplasma infection and facilitate control. " 01/01/1991 - "The utilization of prescreened reagents and antibiotic-free cultivation, plus the application of improved procedures, such as fluorescent dyes and molecular probes for detection, provide effective means of avoiding mycoplasma infection and facilitating control. "
3.	Breast Neoplasms (Breast Cancer) 12/01/2017 - "Our study suggested that SPIO-G3-5MF might be a promising MR molecular probe for diagnosing and monitoring HER2 expression state of breast cancer in the future." 10/14/2020 - "Precise discrimination of breast cancer remains a challenge in clinical medicine, which depends on the development of novel specific molecular probes. " 01/01/2018 - "The results indicate that HER-2-targeted MRI molecular probes may be used in the clinical diagnosis of breast cancer and facilitate the development of promising strategies for breast cancer treatments." 01/01/2018 - "Diagnostic Value of ER, PR, FR and HER-2-Targeted Molecular Probes for Magnetic Resonance Imaging in Patients with Breast Cancer." 01/01/2015 - "The MS03 aptamer may become a promising molecular probe during diagnostic and therapeutic applications in breast cancer."
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2020 - "Development of molecular probes holds great promise for early diagnosis of aggressive prostate cancer. " 10/01/2019 - "Detection of a prostate cancer cell line using a bioluminescent affiprobe: An attempt to develop a new molecular probe for ex vivo studies." 07/01/2015 - "The overall aim of the present study was to assess the diagnostic potential of 131I‑K237 as a molecular probe for prostate cancer. " 01/01/2023 - "The Application of Radiolabeled Targeted Molecular Probes for the Diagnosis and Treatment of Prostate Cancer." 05/14/2020 - "Targeted imaging of orthotopic prostate cancer by using clinical transformable photoacoustic molecular probe."
5.	Glioma (Gliomas) 01/01/2020 - "Therefore, this study confirms that the novel molecular probe USPIO-PEG-tLyP-1 can be used for the grading diagnosis by MRI for gliomas of high and low grade with different NRP-1 expression levels." 04/01/2011 - "In our study, we aimed to assess the expression of VEGFR2 in C6 gliomas by using a specific molecular probe with mMRI. " 02/01/2010 - "This study involved the development and assessment of a novel magnetic resonance imaging (MRI) molecular probe for the in vivo detection of Met in an experimental rodent (rat) model of disease (C6 glioma). " 01/01/2020 - "A new molecular probe: An NRP-1 targeting probe for the grading diagnosis of glioma in nude mice." 01/01/2020 - "Here, we review developments in molecular-targeted diagnosis and therapy in glioma, MI of these targets, and MI monitoring of treatment response, with a focus on the biological mechanisms of these advanced molecular probes. "

Related Drugs and Biologics

1.	Fluorescent Dyes (Fluorescent Probes)
2.	Indicators and Reagents (Reagents)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Tumor Biomarkers (Tumor Markers)
5.	Integrins
6.	Radioisotopes (Radionuclides)
7.	Tubulin
8.	Ligands
9.	Lipids
10.	T-Cell Antigen Receptors (T-Cell Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Precision Medicine
3.	Quantum Dots (Quantum Dot)
4.	Transplantation
5.	Drug Therapy (Chemotherapy)