Molecular Probes (Molecular Probe)

A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.

Also Known As:

Networked: 448 relevant articles (14 outcomes, 70 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cheng, Zhen: 15 articles (12/2013 - 05/2007)
2.	Achilefu, Samuel: 14 articles (12/2014 - 08/2004)
3.	Tan, Weihong: 11 articles (01/2015 - 08/2006)
4.	Liu, Hongguang: 7 articles (12/2013 - 11/2009)
5.	Gambhir, Sanjiv S: 7 articles (01/2013 - 04/2004)
6.	Akers, Walter J: 6 articles (12/2014 - 07/2010)
7.	Miao, Zheng: 6 articles (09/2013 - 09/2009)
8.	Sefah, Kwame: 6 articles (01/2010 - 08/2006)
9.	Wang, Kemin: 5 articles (09/2015 - 07/2007)
10.	Shangguan, Dihua: 5 articles (01/2014 - 08/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2010 - "Most importantly, since this strategy can be implemented without prior knowledge of a target's specific molecular signature, cell-based aptamer selection holds great promise for the development of specific molecular probes for cancer diagnosis and cancer biomarker discovery." 07/01/2009 - "Therefore, tissue slide-based SELEX holds promise in identifying tumour markers and developing specific molecular probes for cancer diagnosis." 08/08/2006 - "The cell-based aptamer selection holds a great promise in developing specific molecular probes for cancer diagnosis and cancer biomarker discovery." 08/13/2015 - "Thus, the p53-activating compounds identified by this approach represent useful molecular probes for various cancer studies. " 05/01/2015 - "This study demonstrated that sdAb EG2 can effectively target EGFR in vitro and in vivo in tumors, suggesting that it could be used as a molecular probe for EGFR detection."
2.	Mycoplasma Infections 01/01/1992 - "The utilization of pre-screened reagents and antibiotic-free cultivation, plus the application of improved procedures, such as fluorescent dyes and molecular probes for detection, provide effective means to avoid mycoplasma infection and facilitate control. " 01/01/1991 - "The utilization of prescreened reagents and antibiotic-free cultivation, plus the application of improved procedures, such as fluorescent dyes and molecular probes for detection, provide effective means of avoiding mycoplasma infection and facilitating control. "
3.	Myeloid Leukemia (Leukemia, Myelocytic) 03/01/1988 - "Study of this BCR-ABL fusion gene has led to the development of molecular probes which are beginning to play an important role in the diagnosis and clinical management of chronic myelogenous leukemia, and may ultimately lead to better understanding of the biology of the disease. " 01/01/1990 - "Studies with G6PD and molecular probes indicate that the myeloid leukemias and the chronic myeloproliferative disorders are clonal diseases. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2015 - "Detection of pulmonary metastases with the novel radiolabeled molecular probe, (99m)Tc-RRL." 01/01/2015 - "To make a definite diagnosis of metastasis, we still need a combination of immunohistochemical and molecular probes. " 01/01/2014 - "The lack of molecular probes for PCa hindered the early diagnosis of metastasis and accurate staging for PCa. " 05/01/2013 - "Early prediction of metastasis is currently impossible due to the lack of specific molecular probes to recognize metastatic HCC cells. " 07/01/2011 - "Finally, diffusion-weighted whole-body MRI is discussed as an alternative offered by MRI that does not require the use of molecular probes to screen distant metastases."
5.	Leukemia 01/01/1988 - "Studies of these five patients support the concepts of molecular and phenotypic heterogeneity in Ph1 acute leukemia, demonstrate a high incidence of AMLL in this subset of acute leukemia, and support the use of lineage-associated molecular probes to define lineage at an earlier stage than previously possible." 11/01/1988 - "However, further investigations, including immunophenotypic and cytoplasmic analysis, ultrastructural cytochemistry and gene analysis with molecular probes (tests applicable to normal myeloid cells), are necessary in order to determine the actual origin of blasts and to recognize the differentiation stages of the various types of leukemic cells from patients with undifferentiated forms of leukemia." 12/10/2008 - "To prove the efficacy of this DDS, three fluorescent and fluorogenic molecular probes were designed, synthesized, characterized, and subjected to the analysis of the receptor-mediated endocytosis and drug release inside the cancer cells (L1210FR leukemia cell line) by means of confocal fluorescence microscopy. " 02/01/2015 - "The novel carborane derivatives could be utilized as important potential molecular probes for specific recognition of cancer cells like leukemia cells from normal cells." 10/01/1988 - "To gain insight into the rearrangements occurring in Ph1+ acute leukemias, a 64-kb DNA fragment from the 5' end of phl was analyzed in order to generate molecular probes covering 40 kb of the phl gene first intron. "

Related Drugs and Biologics

1.	Fluorescent Dyes (Fluorescent Probes)
2.	Indicators and Reagents (Reagents)
3.	Tubulin
4.	Ligands
5.	T-Cell Antigen Receptors (T-Cell Receptor)
6.	Doxorubicin (Adriamycin)
7.	Semaphorin-3A
8.	Thyrotropin Receptors (Thyrotropin Receptor)
9.	xanthofulvin
10.	Nucleotide Aptamers

Related Therapies and Procedures

1.	Quantum Dots (Quantum Dot)
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Radiotherapy
5.	Heterologous Transplantation (Xenotransplantation)