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Cefmetazole (Cefmetazole Sodium)

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A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.

Also Known As:

Cefmetazole Sodium; Zefazone; CS-1170; Cefmetazole Monosodium Salt; Cefmetazon; Pharmacia Brand of Cefmetazole Sodium; U-72791A; CS 1170; CS1170; Monosodium Salt, Cefmetazole; Salt, Cefmetazole Monosodium; Sodium, Cefmetazole; U 72791A; U72791A; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((((cyanomethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-cis)-

Networked: 161 relevant articles (33 outcomes, 36 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Harada, Sohei: 2 articles (03/2013 - 12/2011)
2.	Doi, Shoichi: 1 article (09/2015)
3.	Matsumura, Yasufumi: 1 article (09/2015)
4.	Hayashi, Akihiko: 1 article (09/2015)
5.	Yamamoto, Masaki: 1 article (09/2015)
6.	Shimizu, Tsunehiro: 1 article (09/2015)
7.	Komori, Toshiaki: 1 article (09/2015)
8.	Watanabe, Harumi: 1 article (09/2015)
9.	Nagao, Miki: 1 article (09/2015)
10.	Ichiyama, Satoshi: 1 article (09/2015)

Related Diseases

1.	Infection 01/01/1984 - "Postoperative administration of Cefmetazole was effective for eradication of bacteria from the urine in 26 out of 30 patients and in prevention of infection in 24 cases. " 03/01/1982 - "In order to evaluate the efficacy of cefmetazole (CMZ) against osseous and articular infections fundamentally, the sensitivity of clinically isolated strains of Staphylococcus aureus to the drug and its concentration in serum and bone marrow of tibia were determined. " 06/01/1993 - "This study showed Cefmetazole to be an effective and safe antibiotic for treatment of intraabdominal infection." 03/01/1982 - "[Basic study on efficacy of cefmetazole against osseous and articular infections (author's transl)]." 01/01/1995 - "The efficacy of cefmetazole was studied in an open non-comparative clinical trial comprising 40 patients with infections of the lower respiratory tracts. "
2.	Respiratory Tract Infections (Respiratory Tract Infection) 06/01/1983 - "[Clinical evaluation of the efficacy of cefmetazole in respiratory tract infections of patients with underlying respiratory diseases]." 12/01/1982 - "[Clinical studies on cefmetazole in respiratory infections]." 01/01/1995 - "[Effectiveness of cefmetazole in treatment of lower respiratory tract infections]." 06/01/1983 - "Respiratory infections of 10 subjects with underlying respiratory diseases were treated with cefmetazole (CMZ) and its clinical effects were studied. " 08/01/1980 - "[Massive cefmetazole (CS-1170) therapy for extremely severe respiratory infections (author's transl)]."
3.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1984 - "For the treatment of urinary tract infections with or without complications, 177 patients were administered Cefmetazole. " 04/01/1983 - "Cefmetazole was suggested to be a useful antibiotic for the treatment of urinary tract infections." 01/01/1984 - "Fifty four patients were given Cefmetazole intravenously after urological operation to prevent wound and urinary tract infections. " 04/01/1983 - "The clinical effectiveness of Cefmetazole, a new cephamycin antibiotic, was studied in 13 cases of complicated urinary tract infection and in 3 cases of acute simple pyelonephritis. " 04/01/1989 - "This study evaluates the safety and efficacy of cefmetazole in comparison with cefoxitin in the parenteral treatment of patients hospitalized with acute urinary tract infections. "
4.	Bacterial Infections (Bacterial Infection) 02/01/1979 - "CS-1170 was used for treatment of 26 children who were diagnosed as bacterial infections, and a response rate of 88% was obtained as the drug was effective in 15 of 17 determinable cases. " 02/01/1979 - "CS-1170 was effective in 7 of 8 cases with pediatric bacterial infections. " 11/01/1981 - "[Clinical trials of cefmetazole on the bacterial infections of the skin (author's transl)]." 04/01/1986 - "[Cefmetazole in 2 daily doses in the treatment of bacterial infections]." 09/01/1982 - "The data that the mode of action of this drug is bactericidal with such relatively brief exposure times--indicating rapid decrease of colony-forming units--would suggest cefmetazole is an excellent antibacterial agent and would be a useful drug in treatment of bacterial infections."
5.	Wounds and Injuries (Trauma) 09/01/1989 - "Cefmetazole was also proven very effective in minimizing infectious wound morbidity (prophylaxis) using 2 g single- or multidose regimens. " 09/01/2013 - "The low transition rate of cefmetazole into subcutaneous adipose tissue indicates the need for additional measures, such as high-pressure washing of the subcutaneous wound tissue." 09/01/2013 - "Blood samples were taken at the start of surgery, immediately before administration of the additional dose of cefmetazole, at the time of lesion resection, and at the time of wound closure. " 11/01/1984 - "The levels of cefmetazole in plasma and tissue were determined after injection of a dose of 30 mg/kg into the zone of the wound of each of 15 patients undergoing appendectomy. " 01/01/1984 - "Fifty four patients were given Cefmetazole intravenously after urological operation to prevent wound and urinary tract infections. "

Related Drugs and Biologics

1.	Cefoxitin (Cefoxitin Sodium)
2.	Cefazolin (Ancef)
3.	beta-Lactamases (beta-Lactamase)
4.	Cefmetazole (Cefmetazole Sodium)
5.	Anti-Bacterial Agents (Antibiotics)
6.	Cefotetan (Cefotan)
7.	Ceftazidime (Fortum)
8.	Carbapenems (Carbapenem Antibiotics)
9.	Cephalothin (Cefalotin)
10.	Aztreonam

Related Therapies and Procedures

1.	Cesarean Section (Caesarean Section)
2.	Injections
3.	Hysterectomy
4.	Subcutaneous Injections
5.	Esophagectomy