Ventilator Weaning

Techniques for effecting the transition of the respiratory-failure patient from mechanical ventilation to spontaneous ventilation, while meeting the criteria that tidal volume be above a given threshold (greater than 5 ml/kg), respiratory frequency be below a given count (less than 30 breaths/min), and oxygen partial pressure be above a given threshold (PaO2 greater than 50mm Hg). Weaning studies focus on finding methods to monitor and predict the outcome of mechanical ventilator weaning as well as finding ventilatory support techniques which will facilitate successful weaning. Present methods include intermittent mandatory ventilation, intermittent positive pressure ventilation, and mandatory minute volume ventilation.

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Networked: 165 relevant articles (8 outcomes, 16 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Jonkman, Annemijn H: 3 articles (10/2021 - 07/2019)
2.	McCaughey, Euan J: 3 articles (10/2020 - 01/2015)
3.	Bösel, Julian: 2 articles (01/2022 - 01/2014)
4.	Freeman, William D: 2 articles (01/2022 - 07/2012)
5.	Heunks, Leo: 2 articles (10/2021 - 01/2020)
6.	Pottecher, Julien: 2 articles (02/2021 - 03/2020)
7.	Huang, Jing: 2 articles (01/2021 - 01/2021)
8.	Lin, Xin-Zhu: 2 articles (01/2021 - 01/2021)
9.	Tang, Li-Xia: 2 articles (01/2021 - 01/2021)
10.	Verceles, Avelino C: 2 articles (01/2021 - 04/2014)

Related Diseases

1.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 06/01/2016 - "To investigate the efficacy of heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP) in preterm infants aged 26-31(+6) weeks with respiratory distress syndrome after ventilator weaning. " 01/01/2021 - "There is limited evidence on the impact of protocolized ventilator weaning in pediatric acute respiratory distress syndrome, despite utilization in clinical trials and clinical care. " 06/01/2020 - "This study was performed to explore the association of the high-resolution computed tomography (HRCT) score with ventilator weaning and 28-day mortality of patients with acute respiratory distress syndrome (ARDS). " 12/01/2023 - "Association between ventilator-associated events and implementation of acute respiratory distress syndrome (ARDS) ventilator weaning protocol." 01/01/2021 - "Ventilator-weaning pathway implementation shortened invasive ventilation duration in pediatric acute respiratory distress syndrome survivors with no change in reintubation. "
2.	Quadriplegia (Spastic Quadriplegia) 03/01/2016 - "To determine the safety and efficacy of higher (20 ml kg(-1) ideal body weight (IBW)) vs standard (10 ml kg(-1) IBW) tidal volumes (Vt) for patients with sub-acute traumatic tetraplegia during ventilator weaning using a 14-day (minimum) weaning protocol. " 01/01/2015 - "The aim of this study was to investigate the clinical feasibility of using an AFES training program to improve respiratory function and assist ventilator weaning in acute tetraplegia. " 02/01/1994 - "With an overall weaning success rate of 83%, this study demonstrated that individuals with C3 and C4 quadriplegia are indeed candidates for ventilator weaning. " 01/01/2022 - "Prospective analysis of a surgical algorithm to achieve ventilator weaning in cervical tetraplegia." 01/01/2015 - "Abdominal Functional Electrical Stimulation to Assist Ventilator Weaning in Acute Tetraplegia: A Cohort Study."
3.	Ventilator-Associated Pneumonia 12/01/2001 - "Benefits ascribed to tracheotomy vs prolonged translaryngeal intubation include improved patient comfort, more effective airway suctioning, decreased airway resistance, enhanced patient mobility, increased potential for speech, ability to eat orally, a more secure airway, accelerated ventilator weaning, reduced ventilator-associated pneumonia, and the ability to transfer ventilator-dependent patients from the ICU. " 11/06/2008 - "Studies have shown that ventilator weaning protocols have resulted in a reduction in duration of mechanical ventilation, ventilator-associated pneumonia, and the rate of re-intubation when compared to weaning directed by a physician. " 05/01/2004 - "The effect of protocol-driven ventilator weaning on ventilator use, ventilator-associated pneumonia (VAP), and intensive care unit (ICU) length of stay (LOS) is described in a survey of 2 years' activity in a multidisciplinary surgical ICU. " 05/01/2004 - "Protocol-driven ventilator weaning reduces use of mechanical ventilation, rate of early reintubation, and ventilator-associated pneumonia." 01/01/2019 - "Protocol utilization in central nervous system vs. non- central nervous system patients was as follows: Sedation interruption 973/1266 (76.9%) vs. 3840/4913 (78.2%) (p = .32); acute lung injury ventilation 847/1266 (66.9%) vs. 4069/4913 (82.8%) (p < .0001); ventilator associated pneumonia 1193/1266 (94.2%) vs. 4760/4913 (96.9%) (p < .0001); ventilator weaning 1193/1266 (94.2%) vs. 4490/4913 (91.4%) (p = .0009); and early mobility 378/1266 (29.9%) vs. 1736/4913 (35.3%) (p = .0002). "
4.	Critical Illness (Critically Ill) 01/01/2019 - "We hypothesized that a comprehensive protocol for ventilator weaning and extubation would be effective for preventing PERF and reintubation and reducing mortality in critically ill patients. " 07/01/2023 - "Ventilator weaning and extubation practices in critically ill children: An Australian and New Zealand survey of practice." 01/01/2023 - "Ventilator weaning protocols rely in part on objective indices to best predict extubation failure in the critically ill. " 12/10/2022 - "Diaphragm weakness frequently develops in mechanically ventilated critically ill patients and is associated with increased morbidity, including ventilator weaning failure, mortality, and health care costs. " 10/01/2021 - "Once confirmed in ventilated critically ill patients, this could provide a new mechanism for ventilator-induced diaphragm dysfunction and ventilator weaning failure in the intensive care unit (ICU)."
5.	Apnea 01/01/2021 - "Compared with the routine group, the observation group had significantly lower reintubation rate (P=0.034) and number of apnea episodes (≥2 times/day) (P=0.015) within 48 hours after ventilator weaning. " 11/15/2021 - "A high maintenance dose of caffeine can safely and effectively reduce the incidence rate of apnea after ventilator weaning and the failure rate of ventilator weaning in RDS preterm infants with a gestational age of ≤32 weeks, and therefore, it holds promise for clinical application. " 11/15/2021 - "The high-dose caffeine group had a significantly lower re-intubation rate within 48 hours after ventilator weaning than the low-dose caffeine group (P<0.05), with frequent apnea as the main reason for failed ventilator weaning in both groups. " 01/01/2021 - "The two groups were compared in terms of reintubation rate and number of apnea episodes within 48 hours after ventilator weaning, changes in blood gas parameters, blood glucose, heart rate, and mean blood pressure at 2 hours after ventilator weaning, and incidence rates of major complications during hospitalization. " 12/01/1992 - "Theophylline has been utilized as an adjunct in facilitating ventilator weaning and in the management of apnea with or without bradycardia. "

Related Drugs and Biologics

1.	Caffeine (No Doz)
2.	Adrenal Cortex Hormones (Corticosteroids)
3.	Doxapram (Doxapram Hydrochloride)
4.	Aminophylline (Carine)
5.	caffeine citrate
6.	Brain Natriuretic Peptide (Natrecor)
7.	pro-brain natriuretic peptide (1-76)
8.	Oxygen (Dioxygen)
9.	Hypnotics and Sedatives (Sedatives)
10.	Acetazolamide (Diamox)

Related Therapies and Procedures

1.	Mechanical Ventilators (Ventilator)
2.	Tracheotomy
3.	Cannula
4.	Continuous Positive Airway Pressure
5.	Artificial Respiration (Mechanical Ventilation)