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Ceftizoxime (Cefizox)

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A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.

Also Known As:

Cefizox; Ceftizoxime Sodium; Ceftizoxime Monosodium Salt; FK-749; FK749; FR-13749; Fujiwasa Brand of Cetizoxime Sodium; GlaxoSmithKline Brand of Cetizoxime Sodium; SK&F 88373-2; SKF-88373; Yamanouchi Brand of Ceftizoxime Sodium; FK 749; FR 13749; FR13749; Monosodium Salt, Ceftizoxime; SK&F 88373 2; SK&F 883732; SKF 88373; SKF88373; Salt, Ceftizoxime Monosodium; Sodium, Ceftizoxime; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6alpha,7beta(Z)))-

Networked: 210 relevant articles (25 outcomes, 30 trials/studies)

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Drug Context: Research Results

Experts

1.	Cardoso, Valbert Nascimento: 4 articles (09/2015 - 07/2012)
2.	Serakides, Rogéria: 3 articles (01/2015 - 09/2008)
3.	Ferreira, Diego dos Santos: 2 articles (01/2015 - 07/2012)
4.	Oliveira, Mônica Cristina: 2 articles (01/2015 - 07/2012)
5.	Gyssens, Inge C: 2 articles (10/2007 - 05/2004)
6.	Mouton, Johan W: 2 articles (10/2007 - 05/2004)
7.	Stearne, Lorna E T: 2 articles (10/2007 - 05/2004)
8.	Goessens, Wil H F: 2 articles (10/2007 - 05/2004)
9.	Hatano, Kazuo: 2 articles (05/2006 - 03/2004)
10.	Hanaki, Hideaki: 2 articles (05/2006 - 03/2004)

Related Diseases

1.	Infection 02/01/1991 - "Although ceftizoxime has been used effectively in several clinical trials for infections involving anaerobic bacteria, reports of its in-vitro activity against anaerobes are contradictory and confusing. " 01/01/1990 - "Although ceftizoxime has been used effectively in several clinical trials for infections involving anaerobic bacteria, reports of its in vitro activity against anaerobes are contradictory and confusing. " 01/01/1984 - "The results of the present study suggest that administration of ceftizoxime may be effective in the treatment of biliary tract infections." 01/01/1987 - "The fact that ceftizoxime was effective in four of five patients with Chlamydia trachomatis in cervical isolates suggests that intravenous therapy for the acute infection can be accomplished without the addition of an antichlamydial agent. " 11/01/1982 - "Efficacy of ceftizoxime and related compounds in animals models of infection."
2.	Endometritis 02/01/1986 - "Clinically, combined treatment with CLDM-P and ceftizoxime was excellently effective for endometritis induced by P. " 05/01/1985 - "Single-dose ceftizoxime prophylaxis significantly reduced the incidence of endometritis and febrile morbidity in high-risk patients undergoing cesarean section." 04/01/1992 - "A prospective, randomized, double-blind trial was done to compare the efficacy of cefoxitin (2 grams given intravenously every six hours) with ceftizoxime (2 grams given intravenously every 12 hours) in the treatment of postpartum endometritis. " 04/01/1992 - "We conclude that cefoxitin and ceftizoxime are equally effective in the therapy of postpartum endometritis and that abdominal wound infection is primarily responsible for persistent fever and, therefore, failure of the antibiotic in patients with postpartum endometritis." 12/01/1985 - "Comparative clinical evaluation of ceftizoxime with clindamycin and gentamicin and cefoxitin in the treatment of postcesarean endomyometritis."
3.	Abscess 09/01/2005 - "[99mTc-ceftizoxime scintigraphy in normal rats and abscess induced rats]." 03/01/1997 - "Pharmacokinetics and pharmacodynamics of ceftizoxime in abscess fluid." 10/01/2007 - "Effect of dosing and dosing frequency on the efficacy of ceftizoxime and the emergence of ceftizoxime resistance during the early development of murine abscesses caused by Bacteroides fragilis and Enterobacter cloacae mixed infection." 10/01/2007 - "The selection of ceftizoxime (CZX)-resistant Enterobacter cloacae mutant strains during the development of murine mixed-infection abscesses was studied to determine the PDI that is important for the emergence of resistance and the PDI value needed for the prevention of resistance. " 09/01/1982 - "3. We gave ceftizoxime to 6 patients comprising 4 patients with puerperal fever, 1 with septic abortion and 1 with tubo-ovarian abscess in daily doses of 2 to 3 g by b.i.d or t.i.d intravenous drip infusion for 4--12 days. "
4.	Urinary Tract Infections (Urinary Tract Infection) 12/01/1982 - "Ceftizoxime is a safe and effective antibiotic agent when used as a single agent for complicated urinary tract infections. " 10/01/1984 - "[Clinical evaluation of ceftizoxime in the treatment of complicated urinary tract infections]." 01/01/1984 - "The pharmacokinetic data indicated high and long-lasting concentrations of ceftizoxime, especially in the renal tissue; this makes the drug ideal for the treatment of complicated urinary tract infections with obstruction and involvement of the renal tissue, provided the bacteria present are sensitive. " 01/01/1984 - "Re: Ceftizoxime in the treatment of urinary tract infections." 12/01/1982 - "Therefore, it is recommended that ceftizoxime be reserved for treatment of urinary tract infections stemming from pathogenic species resistant to the less expensive antimicrobials."
5.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/1984 - "The findings indicate that ceftizoxime, 1 to 2 gm BID, is effective and safe in the treatment of lower respiratory tract infections in hospitalized patients. " 01/01/1984 - "Efficacy of ceftizoxime administered twice daily in hospitalized patients with respiratory tract infections." 02/01/1991 - "Ceftizoxime in the treatment of hospital-acquired respiratory infections. " 04/01/1985 - "[Evaluation of ceftizoxime in the treatment of respiratory tract infections]." 09/01/1984 - "[Respiratory infections in chronic bronchopneumopathies: treatment with ceftizoxime]."

Related Drugs and Biologics

1.	Cefoxitin (Cefoxitin Sodium)
2.	Gentamicins (Gentamicin)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Ciprofloxacin (Cipro)
5.	Ofloxacin (Levofloxacin)
6.	Aztreonam
7.	Ceftriaxone (Ceftriaxon)
8.	Cefotaxime (Kendrick)
9.	Ticarcillin (Tarcil)
10.	Metronidazole (Metric)

Related Therapies and Procedures

1.	Chemoprevention
2.	Hysterectomy
3.	Intravenous Injections
4.	Cesarean Section (Caesarean Section)
5.	Subcutaneous Injections